Determinants of COVID-19 disease severity in patients with cancer
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Determinants of COVID-19 disease severity in patients with cancer. / Robilotti, Elizabeth V; Babady, N Esther; Mead, Peter A; Rolling, Thierry; Perez-Johnston, Rocio; Bernardes, Marilia; Bogler, Yael; Caldararo, Mario; Figueroa, Cesar J; Glickman, Michael S; Joanow, Alexa; Kaltsas, Anna; Lee, Yeon Joo; Lucca, Anabella; Mariano, Amanda; Morjaria, Sejal; Nawar, Tamara; Papanicolaou, Genovefa A; Predmore, Jacqueline; Redelman-Sidi, Gil; Schmidt, Elizabeth; Seo, Susan K; Sepkowitz, Kent; Shah, Monika K; Wolchok, Jedd D; Hohl, Tobias M; Taur, Ying; Kamboj, Mini.
in: NAT MED, Jahrgang 26, Nr. 8, 08.2020, S. 1218-1223.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Determinants of COVID-19 disease severity in patients with cancer
AU - Robilotti, Elizabeth V
AU - Babady, N Esther
AU - Mead, Peter A
AU - Rolling, Thierry
AU - Perez-Johnston, Rocio
AU - Bernardes, Marilia
AU - Bogler, Yael
AU - Caldararo, Mario
AU - Figueroa, Cesar J
AU - Glickman, Michael S
AU - Joanow, Alexa
AU - Kaltsas, Anna
AU - Lee, Yeon Joo
AU - Lucca, Anabella
AU - Mariano, Amanda
AU - Morjaria, Sejal
AU - Nawar, Tamara
AU - Papanicolaou, Genovefa A
AU - Predmore, Jacqueline
AU - Redelman-Sidi, Gil
AU - Schmidt, Elizabeth
AU - Seo, Susan K
AU - Sepkowitz, Kent
AU - Shah, Monika K
AU - Wolchok, Jedd D
AU - Hohl, Tobias M
AU - Taur, Ying
AU - Kamboj, Mini
PY - 2020/8
Y1 - 2020/8
N2 - As of 10 April 2020, New York State had 180,458 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 9,385 reported deaths. Patients with cancer comprised 8.4% of deceased individuals1. Population-based studies from China and Italy suggested a higher coronavirus disease 2019 (COVID-19) death rate in patients with cancer2,3, although there is a knowledge gap as to which aspects of cancer and its treatment confer risk of severe COVID-194. This information is critical to balance the competing safety considerations of reducing SARS-CoV-2 exposure and cancer treatment continuation. From 10 March to 7 April 2020, 423 cases of symptomatic COVID-19 were diagnosed at Memorial Sloan Kettering Cancer Center (from a total of 2,035 patients with cancer tested). Of these, 40% were hospitalized for COVID-19, 20% developed severe respiratory illness (including 9% who required mechanical ventilation) and 12% died within 30 d. Age older than 65 years and treatment with immune checkpoint inhibitors (ICIs) were predictors for hospitalization and severe disease, whereas receipt of chemotherapy and major surgery were not. Overall, COVID-19 in patients with cancer is marked by substantial rates of hospitalization and severe outcomes. The association observed between ICI and COVID-19 outcomes in our study will need further interrogation in tumor-specific cohorts.
AB - As of 10 April 2020, New York State had 180,458 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 9,385 reported deaths. Patients with cancer comprised 8.4% of deceased individuals1. Population-based studies from China and Italy suggested a higher coronavirus disease 2019 (COVID-19) death rate in patients with cancer2,3, although there is a knowledge gap as to which aspects of cancer and its treatment confer risk of severe COVID-194. This information is critical to balance the competing safety considerations of reducing SARS-CoV-2 exposure and cancer treatment continuation. From 10 March to 7 April 2020, 423 cases of symptomatic COVID-19 were diagnosed at Memorial Sloan Kettering Cancer Center (from a total of 2,035 patients with cancer tested). Of these, 40% were hospitalized for COVID-19, 20% developed severe respiratory illness (including 9% who required mechanical ventilation) and 12% died within 30 d. Age older than 65 years and treatment with immune checkpoint inhibitors (ICIs) were predictors for hospitalization and severe disease, whereas receipt of chemotherapy and major surgery were not. Overall, COVID-19 in patients with cancer is marked by substantial rates of hospitalization and severe outcomes. The association observed between ICI and COVID-19 outcomes in our study will need further interrogation in tumor-specific cohorts.
U2 - 10.1038/s41591-020-0979-0
DO - 10.1038/s41591-020-0979-0
M3 - SCORING: Journal article
C2 - 32581323
VL - 26
SP - 1218
EP - 1223
JO - NAT MED
JF - NAT MED
SN - 1078-8956
IS - 8
ER -