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Determinants and Prognostic Significance of Hematoma Sedimentation Levels in Acute Intracerebral Hemorrhage

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Determinants and Prognostic Significance of Hematoma Sedimentation Levels in Acute Intracerebral Hemorrhage. / Sato, Shoichiro; Delcourt, Candice; Zhang, Shihong; Arima, Hisatomi; Heeley, Emma; Zheng, Danni; Al-Shahi Salman, Rustam; Stapf, Christian; Tzourio, Christophe; Robinson, Thompson; Lindley, Richard I; Chalmers, John; Anderson, Craig S; INTERACT2 investigators.

in: CEREBROVASC DIS, Jahrgang 41, Nr. 1-2, 2016, S. 80-6.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sato, S, Delcourt, C, Zhang, S, Arima, H, Heeley, E, Zheng, D, Al-Shahi Salman, R, Stapf, C, Tzourio, C, Robinson, T, Lindley, RI, Chalmers, J, Anderson, CS & INTERACT2 investigators 2016, 'Determinants and Prognostic Significance of Hematoma Sedimentation Levels in Acute Intracerebral Hemorrhage', CEREBROVASC DIS, Jg. 41, Nr. 1-2, S. 80-6. https://doi.org/10.1159/000442532

APA

Sato, S., Delcourt, C., Zhang, S., Arima, H., Heeley, E., Zheng, D., Al-Shahi Salman, R., Stapf, C., Tzourio, C., Robinson, T., Lindley, R. I., Chalmers, J., Anderson, C. S., & INTERACT2 investigators (2016). Determinants and Prognostic Significance of Hematoma Sedimentation Levels in Acute Intracerebral Hemorrhage. CEREBROVASC DIS, 41(1-2), 80-6. https://doi.org/10.1159/000442532

Vancouver

Sato S, Delcourt C, Zhang S, Arima H, Heeley E, Zheng D et al. Determinants and Prognostic Significance of Hematoma Sedimentation Levels in Acute Intracerebral Hemorrhage. CEREBROVASC DIS. 2016;41(1-2):80-6. https://doi.org/10.1159/000442532

Bibtex

@article{dc2daef73f9845eb998d08db8bba2cad,
title = "Determinants and Prognostic Significance of Hematoma Sedimentation Levels in Acute Intracerebral Hemorrhage",
abstract = "BACKGROUND: This study aimed at identifying the determinants and prognostic significance of a sedimentation level (fluid-blood level) in the hematoma among patients with acute intracerebral hemorrhage (ICH) who participated in the main Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).METHODS: Post-hoc analysis of the INTERACT2 dataset, a randomized controlled trial of patients with acute ICH with elevated systolic blood pressure (SBP), randomly assigned to intensive (target SBP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Patients with a sedimentation level at baseline assessment on CT, and modified Rankin Scale score at 90-day, were included in these analyses. Factors associated with a sedimentation level and its significance in relation to 90-day clinical outcomes were assessed in univariable and multivariable logistic regression models.RESULTS: Of 2,065 participants, 19 (1%) had sedimentation level on baseline CT, which was independently associated with warfarin use (p = 0.006) and lobar ICH (p = 0.025). Sedimentation level was also associated with death or major disability at 90-day in both crude (84 vs. 53%; p = 0.014) and multivariable analyses adjusted for age, gender, Chinese region, warfarin use, baseline National Institutes of Health Stroke Scale score, onset to CT time, volume and location of ICH, intraventricular extension, and randomized intensive BP lowering (OR 3.94, 95% CI 1.01-15.37; p = 0.049).CONCLUSIONS: The presence of hematoma sedimentation level on baseline CT is associated with warfarin use and lobar location of ICH, and predicts a worse outcome. Although uncommon, sedimentation level is an easily detectable prognostic factor in acute ICH.",
keywords = "Aged, Aged, 80 and over, Anticoagulants, Antihypertensive Agents, Cerebral Hemorrhage, Disease Management, Female, Hematoma, Humans, Hypertension, Logistic Models, Male, Middle Aged, Multivariate Analysis, Prognosis, Risk Factors, Tomography, X-Ray Computed, Warfarin, Journal Article, Research Support, Non-U.S. Gov't",
author = "Shoichiro Sato and Candice Delcourt and Shihong Zhang and Hisatomi Arima and Emma Heeley and Danni Zheng and {Al-Shahi Salman}, Rustam and Christian Stapf and Christophe Tzourio and Thompson Robinson and Lindley, {Richard I} and John Chalmers and Anderson, {Craig S} and {INTERACT2 investigators} and G{\"o}tz Thomalla",
note = "{\textcopyright} 2015 S. Karger AG, Basel.",
year = "2016",
doi = "10.1159/000442532",
language = "English",
volume = "41",
pages = "80--6",
journal = "CEREBROVASC DIS",
issn = "1015-9770",
publisher = "S. Karger AG",
number = "1-2",

}

RIS

TY - JOUR

T1 - Determinants and Prognostic Significance of Hematoma Sedimentation Levels in Acute Intracerebral Hemorrhage

AU - Sato, Shoichiro

AU - Delcourt, Candice

AU - Zhang, Shihong

AU - Arima, Hisatomi

AU - Heeley, Emma

AU - Zheng, Danni

AU - Al-Shahi Salman, Rustam

AU - Stapf, Christian

AU - Tzourio, Christophe

AU - Robinson, Thompson

AU - Lindley, Richard I

AU - Chalmers, John

AU - Anderson, Craig S

AU - INTERACT2 investigators

AU - Thomalla, Götz

N1 - © 2015 S. Karger AG, Basel.

PY - 2016

Y1 - 2016

N2 - BACKGROUND: This study aimed at identifying the determinants and prognostic significance of a sedimentation level (fluid-blood level) in the hematoma among patients with acute intracerebral hemorrhage (ICH) who participated in the main Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).METHODS: Post-hoc analysis of the INTERACT2 dataset, a randomized controlled trial of patients with acute ICH with elevated systolic blood pressure (SBP), randomly assigned to intensive (target SBP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Patients with a sedimentation level at baseline assessment on CT, and modified Rankin Scale score at 90-day, were included in these analyses. Factors associated with a sedimentation level and its significance in relation to 90-day clinical outcomes were assessed in univariable and multivariable logistic regression models.RESULTS: Of 2,065 participants, 19 (1%) had sedimentation level on baseline CT, which was independently associated with warfarin use (p = 0.006) and lobar ICH (p = 0.025). Sedimentation level was also associated with death or major disability at 90-day in both crude (84 vs. 53%; p = 0.014) and multivariable analyses adjusted for age, gender, Chinese region, warfarin use, baseline National Institutes of Health Stroke Scale score, onset to CT time, volume and location of ICH, intraventricular extension, and randomized intensive BP lowering (OR 3.94, 95% CI 1.01-15.37; p = 0.049).CONCLUSIONS: The presence of hematoma sedimentation level on baseline CT is associated with warfarin use and lobar location of ICH, and predicts a worse outcome. Although uncommon, sedimentation level is an easily detectable prognostic factor in acute ICH.

AB - BACKGROUND: This study aimed at identifying the determinants and prognostic significance of a sedimentation level (fluid-blood level) in the hematoma among patients with acute intracerebral hemorrhage (ICH) who participated in the main Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).METHODS: Post-hoc analysis of the INTERACT2 dataset, a randomized controlled trial of patients with acute ICH with elevated systolic blood pressure (SBP), randomly assigned to intensive (target SBP <140 mm Hg) or guideline-based (<180 mm Hg) BP management. Patients with a sedimentation level at baseline assessment on CT, and modified Rankin Scale score at 90-day, were included in these analyses. Factors associated with a sedimentation level and its significance in relation to 90-day clinical outcomes were assessed in univariable and multivariable logistic regression models.RESULTS: Of 2,065 participants, 19 (1%) had sedimentation level on baseline CT, which was independently associated with warfarin use (p = 0.006) and lobar ICH (p = 0.025). Sedimentation level was also associated with death or major disability at 90-day in both crude (84 vs. 53%; p = 0.014) and multivariable analyses adjusted for age, gender, Chinese region, warfarin use, baseline National Institutes of Health Stroke Scale score, onset to CT time, volume and location of ICH, intraventricular extension, and randomized intensive BP lowering (OR 3.94, 95% CI 1.01-15.37; p = 0.049).CONCLUSIONS: The presence of hematoma sedimentation level on baseline CT is associated with warfarin use and lobar location of ICH, and predicts a worse outcome. Although uncommon, sedimentation level is an easily detectable prognostic factor in acute ICH.

KW - Aged

KW - Aged, 80 and over

KW - Anticoagulants

KW - Antihypertensive Agents

KW - Cerebral Hemorrhage

KW - Disease Management

KW - Female

KW - Hematoma

KW - Humans

KW - Hypertension

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Prognosis

KW - Risk Factors

KW - Tomography, X-Ray Computed

KW - Warfarin

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1159/000442532

DO - 10.1159/000442532

M3 - SCORING: Journal article

C2 - 26671408

VL - 41

SP - 80

EP - 86

JO - CEREBROVASC DIS

JF - CEREBROVASC DIS

SN - 1015-9770

IS - 1-2

ER -