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Deterioration of teeth and alveolar bone loss due to chronic environmental high-level fluoride and low calcium exposure

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Deterioration of teeth and alveolar bone loss due to chronic environmental high-level fluoride and low calcium exposure. / Simon, Maciej J K; Beil, Timo; Riedel, Christoph; Lau, Grace; Tomsia, Antoni; Zimmermann, Elizabeth A; Koehne, Till; Ueblacker, Peter; Ruether, Wolfgang; Pogoda, Pia; Ignatius, Anita; Amling, Michael; Oheim, Ralf.

in: CLIN ORAL INVEST, Jahrgang 20, Nr. 9, 12.2016, S. 2361-2370.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Simon, MJK, Beil, T, Riedel, C, Lau, G, Tomsia, A, Zimmermann, EA, Koehne, T, Ueblacker, P, Ruether, W, Pogoda, P, Ignatius, A, Amling, M & Oheim, R 2016, 'Deterioration of teeth and alveolar bone loss due to chronic environmental high-level fluoride and low calcium exposure', CLIN ORAL INVEST, Jg. 20, Nr. 9, S. 2361-2370. https://doi.org/10.1007/s00784-016-1727-1

APA

Simon, M. J. K., Beil, T., Riedel, C., Lau, G., Tomsia, A., Zimmermann, E. A., Koehne, T., Ueblacker, P., Ruether, W., Pogoda, P., Ignatius, A., Amling, M., & Oheim, R. (2016). Deterioration of teeth and alveolar bone loss due to chronic environmental high-level fluoride and low calcium exposure. CLIN ORAL INVEST, 20(9), 2361-2370. https://doi.org/10.1007/s00784-016-1727-1

Vancouver

Simon MJK, Beil T, Riedel C, Lau G, Tomsia A, Zimmermann EA et al. Deterioration of teeth and alveolar bone loss due to chronic environmental high-level fluoride and low calcium exposure. CLIN ORAL INVEST. 2016 Dez;20(9):2361-2370. https://doi.org/10.1007/s00784-016-1727-1

Bibtex

@article{8bdbb454cf5440c4b8beb5ae94a2fec0,
title = "Deterioration of teeth and alveolar bone loss due to chronic environmental high-level fluoride and low calcium exposure",
abstract = "OBJECTIVES: Health risks due to chronic exposure to highly fluoridated groundwater could be underestimated because fluoride might not only influence the teeth in an aesthetic manner but also seems to led to dentoalveolar structure changes. Therefore, we studied the tooth and alveolar bone structures of Dorper sheep chronically exposed to very highly fluoridated and low calcium groundwater in the Kalahari Desert in comparison to controls consuming groundwater with low fluoride and normal calcium levels within the World Health Organization (WHO) recommended range.MATERIALS AND METHODS: Two flocks of Dorper ewes in Namibia were studied. Chemical analyses of water, blood and urine were performed. Mineralized tissue investigations included radiography, HR-pQCT analyses, histomorphometry, energy-dispersive X-ray spectroscopy and X-ray diffraction-analyses.RESULTS: Fluoride levels were significantly elevated in water, blood and urine samples in the Kalahari group compared to the low fluoride control samples. In addition to high fluoride, low calcium levels were detected in the Kalahari water. Tooth height and mandibular bone quality were significantly decreased in sheep, exposed to very high levels of fluoride and low levels of calcium in drinking water. Particularly, bone volume and cortical thickness of the mandibular bone were significantly reduced in these sheep.CONCLUSIONS: The current study suggests that chronic environmental fluoride exposure with levels above the recommended limits in combination with low calcium uptake can cause significant attrition of teeth and a significant impaired mandibular bone quality.CLINICAL RELEVANCE: In the presence of high fluoride and low calcium-associated dental changes, deterioration of the mandibular bone and a potential alveolar bone loss needs to be considered regardless whether other signs of systemic skeletal fluorosis are observed or not.",
author = "Simon, {Maciej J K} and Timo Beil and Christoph Riedel and Grace Lau and Antoni Tomsia and Zimmermann, {Elizabeth A} and Till Koehne and Peter Ueblacker and Wolfgang Ruether and Pia Pogoda and Anita Ignatius and Michael Amling and Ralf Oheim",
year = "2016",
month = dec,
doi = "10.1007/s00784-016-1727-1",
language = "English",
volume = "20",
pages = "2361--2370",
journal = "CLIN ORAL INVEST",
issn = "1432-6981",
publisher = "Springer",
number = "9",

}

RIS

TY - JOUR

T1 - Deterioration of teeth and alveolar bone loss due to chronic environmental high-level fluoride and low calcium exposure

AU - Simon, Maciej J K

AU - Beil, Timo

AU - Riedel, Christoph

AU - Lau, Grace

AU - Tomsia, Antoni

AU - Zimmermann, Elizabeth A

AU - Koehne, Till

AU - Ueblacker, Peter

AU - Ruether, Wolfgang

AU - Pogoda, Pia

AU - Ignatius, Anita

AU - Amling, Michael

AU - Oheim, Ralf

PY - 2016/12

Y1 - 2016/12

N2 - OBJECTIVES: Health risks due to chronic exposure to highly fluoridated groundwater could be underestimated because fluoride might not only influence the teeth in an aesthetic manner but also seems to led to dentoalveolar structure changes. Therefore, we studied the tooth and alveolar bone structures of Dorper sheep chronically exposed to very highly fluoridated and low calcium groundwater in the Kalahari Desert in comparison to controls consuming groundwater with low fluoride and normal calcium levels within the World Health Organization (WHO) recommended range.MATERIALS AND METHODS: Two flocks of Dorper ewes in Namibia were studied. Chemical analyses of water, blood and urine were performed. Mineralized tissue investigations included radiography, HR-pQCT analyses, histomorphometry, energy-dispersive X-ray spectroscopy and X-ray diffraction-analyses.RESULTS: Fluoride levels were significantly elevated in water, blood and urine samples in the Kalahari group compared to the low fluoride control samples. In addition to high fluoride, low calcium levels were detected in the Kalahari water. Tooth height and mandibular bone quality were significantly decreased in sheep, exposed to very high levels of fluoride and low levels of calcium in drinking water. Particularly, bone volume and cortical thickness of the mandibular bone were significantly reduced in these sheep.CONCLUSIONS: The current study suggests that chronic environmental fluoride exposure with levels above the recommended limits in combination with low calcium uptake can cause significant attrition of teeth and a significant impaired mandibular bone quality.CLINICAL RELEVANCE: In the presence of high fluoride and low calcium-associated dental changes, deterioration of the mandibular bone and a potential alveolar bone loss needs to be considered regardless whether other signs of systemic skeletal fluorosis are observed or not.

AB - OBJECTIVES: Health risks due to chronic exposure to highly fluoridated groundwater could be underestimated because fluoride might not only influence the teeth in an aesthetic manner but also seems to led to dentoalveolar structure changes. Therefore, we studied the tooth and alveolar bone structures of Dorper sheep chronically exposed to very highly fluoridated and low calcium groundwater in the Kalahari Desert in comparison to controls consuming groundwater with low fluoride and normal calcium levels within the World Health Organization (WHO) recommended range.MATERIALS AND METHODS: Two flocks of Dorper ewes in Namibia were studied. Chemical analyses of water, blood and urine were performed. Mineralized tissue investigations included radiography, HR-pQCT analyses, histomorphometry, energy-dispersive X-ray spectroscopy and X-ray diffraction-analyses.RESULTS: Fluoride levels were significantly elevated in water, blood and urine samples in the Kalahari group compared to the low fluoride control samples. In addition to high fluoride, low calcium levels were detected in the Kalahari water. Tooth height and mandibular bone quality were significantly decreased in sheep, exposed to very high levels of fluoride and low levels of calcium in drinking water. Particularly, bone volume and cortical thickness of the mandibular bone were significantly reduced in these sheep.CONCLUSIONS: The current study suggests that chronic environmental fluoride exposure with levels above the recommended limits in combination with low calcium uptake can cause significant attrition of teeth and a significant impaired mandibular bone quality.CLINICAL RELEVANCE: In the presence of high fluoride and low calcium-associated dental changes, deterioration of the mandibular bone and a potential alveolar bone loss needs to be considered regardless whether other signs of systemic skeletal fluorosis are observed or not.

U2 - 10.1007/s00784-016-1727-1

DO - 10.1007/s00784-016-1727-1

M3 - SCORING: Journal article

C2 - 26818581

VL - 20

SP - 2361

EP - 2370

JO - CLIN ORAL INVEST

JF - CLIN ORAL INVEST

SN - 1432-6981

IS - 9

ER -