Detection of Retinal Nerve Fiber Layer Defects in Alzheimer's Disease Using SD-OCT
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Detection of Retinal Nerve Fiber Layer Defects in Alzheimer's Disease Using SD-OCT. / Kromer, Robert; Serbecic, Nermin; Hausner, Lucrezia; Froelich, Lutz; Aboul-Enein, Fahmy; Beutelspacher, Sven C.
in: FRONT PSYCHIATRY, Jahrgang 5, 2014, S. 22.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Detection of Retinal Nerve Fiber Layer Defects in Alzheimer's Disease Using SD-OCT
AU - Kromer, Robert
AU - Serbecic, Nermin
AU - Hausner, Lucrezia
AU - Froelich, Lutz
AU - Aboul-Enein, Fahmy
AU - Beutelspacher, Sven C
PY - 2014
Y1 - 2014
N2 - INTRODUCTION: Our aim is to examine the clinical value of spectral-domain optical coherence tomography (Spectralis OCT) to detect retinal nerve fibre layer defects in patients with clinically defined Alzheimer's disease (AD).MATERIAL AND METHODS: This cross-sectional study included 22 patients with AD (mean age: 75.9 ± 6.1 years) and 22 healthy age- and sex-matched controls. Neuro-ophthalmologic examinations and a series of high-resolution OCT examinations of the peripapillary retinal nerve fiber layer (RNFL) thickness using the Spectralis 3.5-mm circle scan protocol with ART-Modus and eye tracking were obtained, and compared to age- and sex-matched healthy control subjects.RESULTS: Patients with AD showed a significant decrease in RNFL thickness in the nasal superior sector compared to the control group (101.0 ± 18.18 μm versus 122.8 ± 28.08 μm; P < 0.0001). In all other sectors, independently of disease duration, no significant difference in RNFL thickness compared to controls was detected. Using the advanced age- and gender-matched measurement model, 32 out of 42 eyes (76.19%) as pathologic with 67 abnormal sectors were detected.DISCUSSION: As examined by spectral-domain OCT, patients with mild to moderate stages of AD showed a significant reduction of RNFL thickness in the nasal superior sector. Nevertheless, successive studies are needed.
AB - INTRODUCTION: Our aim is to examine the clinical value of spectral-domain optical coherence tomography (Spectralis OCT) to detect retinal nerve fibre layer defects in patients with clinically defined Alzheimer's disease (AD).MATERIAL AND METHODS: This cross-sectional study included 22 patients with AD (mean age: 75.9 ± 6.1 years) and 22 healthy age- and sex-matched controls. Neuro-ophthalmologic examinations and a series of high-resolution OCT examinations of the peripapillary retinal nerve fiber layer (RNFL) thickness using the Spectralis 3.5-mm circle scan protocol with ART-Modus and eye tracking were obtained, and compared to age- and sex-matched healthy control subjects.RESULTS: Patients with AD showed a significant decrease in RNFL thickness in the nasal superior sector compared to the control group (101.0 ± 18.18 μm versus 122.8 ± 28.08 μm; P < 0.0001). In all other sectors, independently of disease duration, no significant difference in RNFL thickness compared to controls was detected. Using the advanced age- and gender-matched measurement model, 32 out of 42 eyes (76.19%) as pathologic with 67 abnormal sectors were detected.DISCUSSION: As examined by spectral-domain OCT, patients with mild to moderate stages of AD showed a significant reduction of RNFL thickness in the nasal superior sector. Nevertheless, successive studies are needed.
U2 - 10.3389/fpsyt.2014.00022
DO - 10.3389/fpsyt.2014.00022
M3 - SCORING: Journal article
C2 - 24616709
VL - 5
SP - 22
JO - FRONT PSYCHIATRY
JF - FRONT PSYCHIATRY
SN - 1664-0640
ER -
