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Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.

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Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations. / Ehmann, Falk; Horn, Stefan; Garcia-Palma, Lizet; Wegner, Wiebke; Fiedler, Walter; Giehl, Klaudia; Mayr, Georg W.; Jücker, Manfred.

in: LEUKEMIA LYMPHOMA, Jahrgang 47, Nr. 7, 7, 2006, S. 1387-1391.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ehmann, F, Horn, S, Garcia-Palma, L, Wegner, W, Fiedler, W, Giehl, K, Mayr, GW & Jücker, M 2006, 'Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.', LEUKEMIA LYMPHOMA, Jg. 47, Nr. 7, 7, S. 1387-1391. <http://www.ncbi.nlm.nih.gov/pubmed/16923573?dopt=Citation>

APA

Ehmann, F., Horn, S., Garcia-Palma, L., Wegner, W., Fiedler, W., Giehl, K., Mayr, G. W., & Jücker, M. (2006). Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations. LEUKEMIA LYMPHOMA, 47(7), 1387-1391. [7]. http://www.ncbi.nlm.nih.gov/pubmed/16923573?dopt=Citation

Vancouver

Ehmann F, Horn S, Garcia-Palma L, Wegner W, Fiedler W, Giehl K et al. Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations. LEUKEMIA LYMPHOMA. 2006;47(7):1387-1391. 7.

Bibtex

@article{ff29acc532d640a2a63e331c5165736c,
title = "Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.",
abstract = "RAS genes, predominantly N-RAS and K-RAS, have been implicated in the pathogenesis of acute myeloid leukemia (AML), due to activating RAS mutations detectable in approximately 20% of AML patients. In the present study, RAS proteins were detected in their activated, GTP-bound form, in AML patients (n = 10) not expressing mutated forms of H-RAS, K-RAS and N-RAS. Further analysis revealed the simultaneous presence of N-RAS and K-RAS proteins in the GTP-bound state in seven out of 10 AML samples. In four out of 10 samples the levels of RAS-GTP were comparable to an AML cell line (TF-1) with an activating N-RAS mutation (Q61P). The detection of RAS-GTP in AML patients without RAS mutations further supports a functional role of RAS proteins in the pathogenesis of AML and may explain the observed effects of RAS inhibitors in some AML patients in the absence of activating RAS mutations.",
author = "Falk Ehmann and Stefan Horn and Lizet Garcia-Palma and Wiebke Wegner and Walter Fiedler and Klaudia Giehl and Mayr, {Georg W.} and Manfred J{\"u}cker",
year = "2006",
language = "Deutsch",
volume = "47",
pages = "1387--1391",
journal = "LEUKEMIA LYMPHOMA",
issn = "1042-8194",
publisher = "informa healthcare",
number = "7",

}

RIS

TY - JOUR

T1 - Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.

AU - Ehmann, Falk

AU - Horn, Stefan

AU - Garcia-Palma, Lizet

AU - Wegner, Wiebke

AU - Fiedler, Walter

AU - Giehl, Klaudia

AU - Mayr, Georg W.

AU - Jücker, Manfred

PY - 2006

Y1 - 2006

N2 - RAS genes, predominantly N-RAS and K-RAS, have been implicated in the pathogenesis of acute myeloid leukemia (AML), due to activating RAS mutations detectable in approximately 20% of AML patients. In the present study, RAS proteins were detected in their activated, GTP-bound form, in AML patients (n = 10) not expressing mutated forms of H-RAS, K-RAS and N-RAS. Further analysis revealed the simultaneous presence of N-RAS and K-RAS proteins in the GTP-bound state in seven out of 10 AML samples. In four out of 10 samples the levels of RAS-GTP were comparable to an AML cell line (TF-1) with an activating N-RAS mutation (Q61P). The detection of RAS-GTP in AML patients without RAS mutations further supports a functional role of RAS proteins in the pathogenesis of AML and may explain the observed effects of RAS inhibitors in some AML patients in the absence of activating RAS mutations.

AB - RAS genes, predominantly N-RAS and K-RAS, have been implicated in the pathogenesis of acute myeloid leukemia (AML), due to activating RAS mutations detectable in approximately 20% of AML patients. In the present study, RAS proteins were detected in their activated, GTP-bound form, in AML patients (n = 10) not expressing mutated forms of H-RAS, K-RAS and N-RAS. Further analysis revealed the simultaneous presence of N-RAS and K-RAS proteins in the GTP-bound state in seven out of 10 AML samples. In four out of 10 samples the levels of RAS-GTP were comparable to an AML cell line (TF-1) with an activating N-RAS mutation (Q61P). The detection of RAS-GTP in AML patients without RAS mutations further supports a functional role of RAS proteins in the pathogenesis of AML and may explain the observed effects of RAS inhibitors in some AML patients in the absence of activating RAS mutations.

M3 - SCORING: Zeitschriftenaufsatz

VL - 47

SP - 1387

EP - 1391

JO - LEUKEMIA LYMPHOMA

JF - LEUKEMIA LYMPHOMA

SN - 1042-8194

IS - 7

M1 - 7

ER -