Detection, clinical relevance and specific biological properties of disseminating tumour cells.
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Detection, clinical relevance and specific biological properties of disseminating tumour cells. / Pantel, Klaus; Brakenhoff, Ruud H; Brandt, Burkhard.
in: NAT REV CANCER, Jahrgang 8, Nr. 5, 5, 2008, S. 329-340.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Detection, clinical relevance and specific biological properties of disseminating tumour cells.
AU - Pantel, Klaus
AU - Brakenhoff, Ruud H
AU - Brandt, Burkhard
PY - 2008
Y1 - 2008
N2 - Most cancer deaths are caused by haematogenous metastatic spread and subsequent growth of tumour cells at distant organs. Disseminating tumour cells present in the peripheral blood and bone marrow can now be detected and characterized at the single-cell level. These cells are highly relevant to the study of the biology of early metastatic spread and provide a diagnostic source in patients with overt metastases. Here we review the evidence that disseminating tumour cells have a variety of uses for understanding tumour biology and improving cancer treatment.
AB - Most cancer deaths are caused by haematogenous metastatic spread and subsequent growth of tumour cells at distant organs. Disseminating tumour cells present in the peripheral blood and bone marrow can now be detected and characterized at the single-cell level. These cells are highly relevant to the study of the biology of early metastatic spread and provide a diagnostic source in patients with overt metastases. Here we review the evidence that disseminating tumour cells have a variety of uses for understanding tumour biology and improving cancer treatment.
M3 - SCORING: Zeitschriftenaufsatz
VL - 8
SP - 329
EP - 340
JO - NAT REV CANCER
JF - NAT REV CANCER
SN - 1474-175X
IS - 5
M1 - 5
ER -
