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Depressive symptoms and metabolic risk: effects of cortisol and gender.

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Depressive symptoms and metabolic risk: effects of cortisol and gender. / Muhtz, Christoph; Zyriax, Birgit-Christiane; Klähn, Tilman; Windler, Eberhard; Otte, Christian.

in: PSYCHONEUROENDOCRINO, Jahrgang 34, Nr. 7, 7, 08.2009, S. 1004-1011.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Muhtz, C, Zyriax, B-C, Klähn, T, Windler, E & Otte, C 2009, 'Depressive symptoms and metabolic risk: effects of cortisol and gender.', PSYCHONEUROENDOCRINO, Jg. 34, Nr. 7, 7, S. 1004-1011. https://doi.org/10.1016/j.psyneuen.2009.01.016

APA

Muhtz, C., Zyriax, B-C., Klähn, T., Windler, E., & Otte, C. (2009). Depressive symptoms and metabolic risk: effects of cortisol and gender. PSYCHONEUROENDOCRINO, 34(7), 1004-1011. [7]. https://doi.org/10.1016/j.psyneuen.2009.01.016

Vancouver

Muhtz C, Zyriax B-C, Klähn T, Windler E, Otte C. Depressive symptoms and metabolic risk: effects of cortisol and gender. PSYCHONEUROENDOCRINO. 2009 Aug;34(7):1004-1011. 7. https://doi.org/10.1016/j.psyneuen.2009.01.016

Bibtex

@article{1133df3507824737bbfc3b3913444739,
title = "Depressive symptoms and metabolic risk: effects of cortisol and gender.",
abstract = "We examined gender effects and the role of cortisol in the association between depressive symptoms and metabolic risk in the Stress, Atherosclerosis, and ECG Study (STRATEGY). In 215 healthy adults from the general population (n=107 men, n=108 women, distributed equally across four age groups, 30-70 years), we assessed depressive symptoms by the Patient Health Questionnaire (PHQ score >10) and measured variables of the metabolic syndrome: high-density lipoprotein (HDL), triglycerides, systolic and diastolic blood pressure, fasting blood glucose and waist circumference. Salivary cortisol was assessed at 08:00, 12:00, 16:00 and 22:00 h. Depressive symptoms were not associated with the metabolic syndrome as entity in the total sample or in men and women separately. However, women with depressive symptoms had larger waist circumferences, higher fasting blood glucose, lower HDL-cholesterol, higher diastolic blood pressure, and higher 16:00 and 22:00 h salivary cortisol compared to women without depressive symptoms. These results persisted after adjusting for age, education, smoking, and physical activity. In adjusted regression analyses, inclusion of cortisol attenuated the association between depressive symptoms and waist, fasting glucose, HDL and diastolic blood pressure in women. In men, we did not find an association between depressive symptoms and variables of the metabolic syndrome. In women, depressive symptoms are associated with several variables of the metabolic syndrome. Elevated afternoon and evening cortisol appear to partially mediate this association.",
keywords = "Adult, Age Factors, Aged, Blood Glucose, Blood Pressure, Cholesterol, HDL/blood, Circadian Rhythm, Depression/complications, Female, Humans, Hydrocortisone/metabolism, Male, Metabolic Syndrome/etiology, Middle Aged, Risk Factors, Saliva/chemistry, Sex Characteristics, Triglycerides/blood, Waist Circumference",
author = "Christoph Muhtz and Birgit-Christiane Zyriax and Tilman Kl{\"a}hn and Eberhard Windler and Christian Otte",
year = "2009",
month = aug,
doi = "10.1016/j.psyneuen.2009.01.016",
language = "English",
volume = "34",
pages = "1004--1011",
journal = "PSYCHONEUROENDOCRINO",
issn = "0306-4530",
publisher = "Elsevier Limited",
number = "7",

}

RIS

TY - JOUR

T1 - Depressive symptoms and metabolic risk: effects of cortisol and gender.

AU - Muhtz, Christoph

AU - Zyriax, Birgit-Christiane

AU - Klähn, Tilman

AU - Windler, Eberhard

AU - Otte, Christian

PY - 2009/8

Y1 - 2009/8

N2 - We examined gender effects and the role of cortisol in the association between depressive symptoms and metabolic risk in the Stress, Atherosclerosis, and ECG Study (STRATEGY). In 215 healthy adults from the general population (n=107 men, n=108 women, distributed equally across four age groups, 30-70 years), we assessed depressive symptoms by the Patient Health Questionnaire (PHQ score >10) and measured variables of the metabolic syndrome: high-density lipoprotein (HDL), triglycerides, systolic and diastolic blood pressure, fasting blood glucose and waist circumference. Salivary cortisol was assessed at 08:00, 12:00, 16:00 and 22:00 h. Depressive symptoms were not associated with the metabolic syndrome as entity in the total sample or in men and women separately. However, women with depressive symptoms had larger waist circumferences, higher fasting blood glucose, lower HDL-cholesterol, higher diastolic blood pressure, and higher 16:00 and 22:00 h salivary cortisol compared to women without depressive symptoms. These results persisted after adjusting for age, education, smoking, and physical activity. In adjusted regression analyses, inclusion of cortisol attenuated the association between depressive symptoms and waist, fasting glucose, HDL and diastolic blood pressure in women. In men, we did not find an association between depressive symptoms and variables of the metabolic syndrome. In women, depressive symptoms are associated with several variables of the metabolic syndrome. Elevated afternoon and evening cortisol appear to partially mediate this association.

AB - We examined gender effects and the role of cortisol in the association between depressive symptoms and metabolic risk in the Stress, Atherosclerosis, and ECG Study (STRATEGY). In 215 healthy adults from the general population (n=107 men, n=108 women, distributed equally across four age groups, 30-70 years), we assessed depressive symptoms by the Patient Health Questionnaire (PHQ score >10) and measured variables of the metabolic syndrome: high-density lipoprotein (HDL), triglycerides, systolic and diastolic blood pressure, fasting blood glucose and waist circumference. Salivary cortisol was assessed at 08:00, 12:00, 16:00 and 22:00 h. Depressive symptoms were not associated with the metabolic syndrome as entity in the total sample or in men and women separately. However, women with depressive symptoms had larger waist circumferences, higher fasting blood glucose, lower HDL-cholesterol, higher diastolic blood pressure, and higher 16:00 and 22:00 h salivary cortisol compared to women without depressive symptoms. These results persisted after adjusting for age, education, smoking, and physical activity. In adjusted regression analyses, inclusion of cortisol attenuated the association between depressive symptoms and waist, fasting glucose, HDL and diastolic blood pressure in women. In men, we did not find an association between depressive symptoms and variables of the metabolic syndrome. In women, depressive symptoms are associated with several variables of the metabolic syndrome. Elevated afternoon and evening cortisol appear to partially mediate this association.

KW - Adult

KW - Age Factors

KW - Aged

KW - Blood Glucose

KW - Blood Pressure

KW - Cholesterol, HDL/blood

KW - Circadian Rhythm

KW - Depression/complications

KW - Female

KW - Humans

KW - Hydrocortisone/metabolism

KW - Male

KW - Metabolic Syndrome/etiology

KW - Middle Aged

KW - Risk Factors

KW - Saliva/chemistry

KW - Sex Characteristics

KW - Triglycerides/blood

KW - Waist Circumference

U2 - 10.1016/j.psyneuen.2009.01.016

DO - 10.1016/j.psyneuen.2009.01.016

M3 - SCORING: Journal article

C2 - 19278789

VL - 34

SP - 1004

EP - 1011

JO - PSYCHONEUROENDOCRINO

JF - PSYCHONEUROENDOCRINO

SN - 0306-4530

IS - 7

M1 - 7

ER -