Depression in atrial fibrillation in the general population
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Depression in atrial fibrillation in the general population. / Schnabel, Renate B; Michal, Matthias; Wilde, Sandra; Wiltink, Jörg; Wild, Philipp S; Sinning, Christoph R; Lubos, Edith; Ojeda, Francisco M; Zeller, Tanja; Munzel, Thomas; Blankenberg, Stefan; Beutel, Manfred E.
in: PLOS ONE, Jahrgang 8, Nr. 12, 2013, S. e79109.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Depression in atrial fibrillation in the general population
AU - Schnabel, Renate B
AU - Michal, Matthias
AU - Wilde, Sandra
AU - Wiltink, Jörg
AU - Wild, Philipp S
AU - Sinning, Christoph R
AU - Lubos, Edith
AU - Ojeda, Francisco M
AU - Zeller, Tanja
AU - Munzel, Thomas
AU - Blankenberg, Stefan
AU - Beutel, Manfred E
PY - 2013
Y1 - 2013
N2 - BACKGROUND: Initial evidence suggests that depressive symptoms are more frequent in patients with atrial fibrillation. Data from the general population are limited.METHODS AND RESULTS: In 10,000 individuals (mean age 56±11 years, 49.4% women) of the population-based Gutenberg Health Study we assessed depression by the Patient Health Questionnaire (PHQ-9) and a history of depression in relation to manifest atrial fibrillation (n = 309 cases). The median (25th/75th percentile) PHQ-9 score of depressive symptoms was 4 (2/6) in atrial fibrillation individuals versus 3 (2/6) individuals without atrial fibrillation, P(X2-Test) = 0.32. Multivariable regression analyses of the severity of depressive symptoms in relation to atrial fibrillation in cardiovascular risk factor adjusted models revealed a relation of PHQ-9 values and atrial fibrillation (odds ratio (OR) 1.04, 95% confidence interval (CI) 1.01-1.08; P = 0.023). The association was stronger for the somatic symptom dimension of depression (OR 1.08, 95% CI 1.02-1.15; P = 0.0085) than for cognitive symptoms (OR 1.05, 95% CI 0.98-1.11; P = 0.15). Results did not change markedly after additional adjustment for heart failure, partnership status or the inflammatory biomarker C-reactive protein. Both, self-reported physical health status, very good/good versus fair/bad, (OR 0.54, 95% CI 0.41-0.70; P<0.001) and mental health status (OR 0.61 (0.46-0.82); P = 0.0012) were associated with atrial fibrillation in multivariable-adjusted models.CONCLUSIONS: In a population-based sample we observed a higher burden of depressive symptoms driven by somatic symptom dimensions in individuals with atrial fibrillation. Depression was associated with a worse perception of physical or mental health status. Whether screening and treatment of depressive symptoms modulates disease progression and outcome needs to be shown.
AB - BACKGROUND: Initial evidence suggests that depressive symptoms are more frequent in patients with atrial fibrillation. Data from the general population are limited.METHODS AND RESULTS: In 10,000 individuals (mean age 56±11 years, 49.4% women) of the population-based Gutenberg Health Study we assessed depression by the Patient Health Questionnaire (PHQ-9) and a history of depression in relation to manifest atrial fibrillation (n = 309 cases). The median (25th/75th percentile) PHQ-9 score of depressive symptoms was 4 (2/6) in atrial fibrillation individuals versus 3 (2/6) individuals without atrial fibrillation, P(X2-Test) = 0.32. Multivariable regression analyses of the severity of depressive symptoms in relation to atrial fibrillation in cardiovascular risk factor adjusted models revealed a relation of PHQ-9 values and atrial fibrillation (odds ratio (OR) 1.04, 95% confidence interval (CI) 1.01-1.08; P = 0.023). The association was stronger for the somatic symptom dimension of depression (OR 1.08, 95% CI 1.02-1.15; P = 0.0085) than for cognitive symptoms (OR 1.05, 95% CI 0.98-1.11; P = 0.15). Results did not change markedly after additional adjustment for heart failure, partnership status or the inflammatory biomarker C-reactive protein. Both, self-reported physical health status, very good/good versus fair/bad, (OR 0.54, 95% CI 0.41-0.70; P<0.001) and mental health status (OR 0.61 (0.46-0.82); P = 0.0012) were associated with atrial fibrillation in multivariable-adjusted models.CONCLUSIONS: In a population-based sample we observed a higher burden of depressive symptoms driven by somatic symptom dimensions in individuals with atrial fibrillation. Depression was associated with a worse perception of physical or mental health status. Whether screening and treatment of depressive symptoms modulates disease progression and outcome needs to be shown.
KW - Adult
KW - Aged
KW - Atrial Fibrillation/complications
KW - C-Reactive Protein/metabolism
KW - Depression/complications
KW - Female
KW - Germany/epidemiology
KW - Heart Failure/pathology
KW - Humans
KW - Male
KW - Middle Aged
KW - Multivariate Analysis
KW - Severity of Illness Index
KW - Surveys and Questionnaires
U2 - 10.1371/journal.pone.0079109
DO - 10.1371/journal.pone.0079109
M3 - SCORING: Journal article
C2 - 24324579
VL - 8
SP - e79109
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 12
ER -
