Depression comorbidity in spinocerebellar ataxia.
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Depression comorbidity in spinocerebellar ataxia. / Schmitz-Hübsch, Tanja; Coudert, Mathieu; Sophie, Tezenas Du Montcel; Giunti, Paola; Labrum, Robyn; Dürr, Alexandra; Ribai, Pascale; Charles, Perrine; Linnemann, Christoph; Schöls, Ludger; Rakowicz, Maryla; Rola, Rafal; Zdzienicka, Elszbieta; Fancellu, Roberto; Mariotti, Caterina; Baliko, Lazlo; Melegh, Bela; Filla, Alessandro; Salvatore, Elena; Warrenburg, van de; Bart, P C; Szymanski, Sandra; Infante, Jon; Timmann, Dagmar; Boesch, Sylvia; Depondt, Chantal; Kang, Jun-Suk; Schulz, Jörg B; Klopstock, Thomas; Löwe, Bernd; Löwe, Bernd; Frick, Caroline; Rottländer, Daniela; Schlaepfer, Thomas E; Klockgether, Thomas.
in: MOVEMENT DISORD, Jahrgang 26, Nr. 5, 5, 2011, S. 870-876.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Depression comorbidity in spinocerebellar ataxia.
AU - Schmitz-Hübsch, Tanja
AU - Coudert, Mathieu
AU - Sophie, Tezenas Du Montcel
AU - Giunti, Paola
AU - Labrum, Robyn
AU - Dürr, Alexandra
AU - Ribai, Pascale
AU - Charles, Perrine
AU - Linnemann, Christoph
AU - Schöls, Ludger
AU - Rakowicz, Maryla
AU - Rola, Rafal
AU - Zdzienicka, Elszbieta
AU - Fancellu, Roberto
AU - Mariotti, Caterina
AU - Baliko, Lazlo
AU - Melegh, Bela
AU - Filla, Alessandro
AU - Salvatore, Elena
AU - Warrenburg, van de
AU - Bart, P C
AU - Szymanski, Sandra
AU - Infante, Jon
AU - Timmann, Dagmar
AU - Boesch, Sylvia
AU - Depondt, Chantal
AU - Kang, Jun-Suk
AU - Schulz, Jörg B
AU - Klopstock, Thomas
AU - Löwe, Bernd
AU - Löwe, Bernd
AU - Frick, Caroline
AU - Rottländer, Daniela
AU - Schlaepfer, Thomas E
AU - Klockgether, Thomas
PY - 2011
Y1 - 2011
N2 - This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self-assessment was compared with an interview-based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement-related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown.
AB - This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self-assessment was compared with an interview-based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement-related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown.
KW - Comorbidity
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Prevalence
KW - Antidepressive Agents/therapeutic use
KW - Depression/drug therapy/epidemiology
KW - Spinocerebellar Ataxias/epidemiology/genetics
KW - Comorbidity
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Prevalence
KW - Antidepressive Agents/therapeutic use
KW - Depression/drug therapy/epidemiology
KW - Spinocerebellar Ataxias/epidemiology/genetics
M3 - SCORING: Journal article
VL - 26
SP - 870
EP - 876
JO - MOVEMENT DISORD
JF - MOVEMENT DISORD
SN - 0885-3185
IS - 5
M1 - 5
ER -
