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Depression as an independent risk factor for mortality in critically ill patients

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Depression as an independent risk factor for mortality in critically ill patients. / Wewalka, Marlene; Warszawska, Joanna; Strunz, Volker; Kitzberger, Reinhard; Holzinger, Ulrike; Fuhrmann, Valentin; Zauner, Christian; Miehsler, Wolfgang; Moser, Gabriele.

in: PSYCHOSOM MED, Jahrgang 77, Nr. 2, 30.01.2015, S. 106-13.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wewalka, M, Warszawska, J, Strunz, V, Kitzberger, R, Holzinger, U, Fuhrmann, V, Zauner, C, Miehsler, W & Moser, G 2015, 'Depression as an independent risk factor for mortality in critically ill patients', PSYCHOSOM MED, Jg. 77, Nr. 2, S. 106-13. https://doi.org/10.1097/PSY.0000000000000137

APA

Wewalka, M., Warszawska, J., Strunz, V., Kitzberger, R., Holzinger, U., Fuhrmann, V., Zauner, C., Miehsler, W., & Moser, G. (2015). Depression as an independent risk factor for mortality in critically ill patients. PSYCHOSOM MED, 77(2), 106-13. https://doi.org/10.1097/PSY.0000000000000137

Vancouver

Wewalka M, Warszawska J, Strunz V, Kitzberger R, Holzinger U, Fuhrmann V et al. Depression as an independent risk factor for mortality in critically ill patients. PSYCHOSOM MED. 2015 Jan 30;77(2):106-13. https://doi.org/10.1097/PSY.0000000000000137

Bibtex

@article{bcbf675267094c00bab943103bab459b,
title = "Depression as an independent risk factor for mortality in critically ill patients",
abstract = "OBJECTIVE: Mortality on medical intensive care units (ICU) is approximately 25%. It is associated with age, severity of illness, and comorbidities. Preexisting depression is a risk factor for worse outcome in many diseases. The impact of depression on outcome of ICU patients has not been investigated. We assessed a possible association between mortality and preexisting depressive mood at the time of ICU admission. The primary end point was 28-day mortality.METHODS: This single-center cohort study was conducted in a tertiary medical ICU. Two hundred patients were evaluated for preexisting depressive mood at ICU admission, determined by Hospital Anxiety and Depression Scale (HADS) score ≥8 in the depression dimension in patients with appropriate cognitive function. Patients with insufficient cognitive function were assessed using observer rating by next of kin by Hammond scale (cutoff ≥4) and/or a modified version of the Hospital Anxiety and Depression Scale for observer rating (cutoff ≥10).RESULTS: In total, 66 (33%) of 200 patients were classified with preexisting depressive mood. Forty-nine (24.5%) of 200 patients had died by day 28. Of these, 23 (47%) had preexisting depressive mood as compared with 43 of 151 (29%) 28-day survivors (p = .017). Multiple logistic regression analysis revealed that preexisting depressive mood at the time of ICU admission is an independent risk factor for 28-day (odds ratio = 2.2, 95% confidence interval = 1.08-4.5, p = .030) and in-hospital mortality (median time till death = 20.5 [2-186] days, odds ratio = 2.58, 95% confidence interval = 1.31-5.1, p = .006).CONCLUSION: Preexisting depressive mood might be an independent risk factor for 28-day mortality in medical ICU patients. This could have diagnostic and therapeutic implications for critically ill patients.",
author = "Marlene Wewalka and Joanna Warszawska and Volker Strunz and Reinhard Kitzberger and Ulrike Holzinger and Valentin Fuhrmann and Christian Zauner and Wolfgang Miehsler and Gabriele Moser",
year = "2015",
month = jan,
day = "30",
doi = "10.1097/PSY.0000000000000137",
language = "English",
volume = "77",
pages = "106--13",
journal = "PSYCHOSOM MED",
issn = "0033-3174",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

RIS

TY - JOUR

T1 - Depression as an independent risk factor for mortality in critically ill patients

AU - Wewalka, Marlene

AU - Warszawska, Joanna

AU - Strunz, Volker

AU - Kitzberger, Reinhard

AU - Holzinger, Ulrike

AU - Fuhrmann, Valentin

AU - Zauner, Christian

AU - Miehsler, Wolfgang

AU - Moser, Gabriele

PY - 2015/1/30

Y1 - 2015/1/30

N2 - OBJECTIVE: Mortality on medical intensive care units (ICU) is approximately 25%. It is associated with age, severity of illness, and comorbidities. Preexisting depression is a risk factor for worse outcome in many diseases. The impact of depression on outcome of ICU patients has not been investigated. We assessed a possible association between mortality and preexisting depressive mood at the time of ICU admission. The primary end point was 28-day mortality.METHODS: This single-center cohort study was conducted in a tertiary medical ICU. Two hundred patients were evaluated for preexisting depressive mood at ICU admission, determined by Hospital Anxiety and Depression Scale (HADS) score ≥8 in the depression dimension in patients with appropriate cognitive function. Patients with insufficient cognitive function were assessed using observer rating by next of kin by Hammond scale (cutoff ≥4) and/or a modified version of the Hospital Anxiety and Depression Scale for observer rating (cutoff ≥10).RESULTS: In total, 66 (33%) of 200 patients were classified with preexisting depressive mood. Forty-nine (24.5%) of 200 patients had died by day 28. Of these, 23 (47%) had preexisting depressive mood as compared with 43 of 151 (29%) 28-day survivors (p = .017). Multiple logistic regression analysis revealed that preexisting depressive mood at the time of ICU admission is an independent risk factor for 28-day (odds ratio = 2.2, 95% confidence interval = 1.08-4.5, p = .030) and in-hospital mortality (median time till death = 20.5 [2-186] days, odds ratio = 2.58, 95% confidence interval = 1.31-5.1, p = .006).CONCLUSION: Preexisting depressive mood might be an independent risk factor for 28-day mortality in medical ICU patients. This could have diagnostic and therapeutic implications for critically ill patients.

AB - OBJECTIVE: Mortality on medical intensive care units (ICU) is approximately 25%. It is associated with age, severity of illness, and comorbidities. Preexisting depression is a risk factor for worse outcome in many diseases. The impact of depression on outcome of ICU patients has not been investigated. We assessed a possible association between mortality and preexisting depressive mood at the time of ICU admission. The primary end point was 28-day mortality.METHODS: This single-center cohort study was conducted in a tertiary medical ICU. Two hundred patients were evaluated for preexisting depressive mood at ICU admission, determined by Hospital Anxiety and Depression Scale (HADS) score ≥8 in the depression dimension in patients with appropriate cognitive function. Patients with insufficient cognitive function were assessed using observer rating by next of kin by Hammond scale (cutoff ≥4) and/or a modified version of the Hospital Anxiety and Depression Scale for observer rating (cutoff ≥10).RESULTS: In total, 66 (33%) of 200 patients were classified with preexisting depressive mood. Forty-nine (24.5%) of 200 patients had died by day 28. Of these, 23 (47%) had preexisting depressive mood as compared with 43 of 151 (29%) 28-day survivors (p = .017). Multiple logistic regression analysis revealed that preexisting depressive mood at the time of ICU admission is an independent risk factor for 28-day (odds ratio = 2.2, 95% confidence interval = 1.08-4.5, p = .030) and in-hospital mortality (median time till death = 20.5 [2-186] days, odds ratio = 2.58, 95% confidence interval = 1.31-5.1, p = .006).CONCLUSION: Preexisting depressive mood might be an independent risk factor for 28-day mortality in medical ICU patients. This could have diagnostic and therapeutic implications for critically ill patients.

U2 - 10.1097/PSY.0000000000000137

DO - 10.1097/PSY.0000000000000137

M3 - SCORING: Journal article

C2 - 25626990

VL - 77

SP - 106

EP - 113

JO - PSYCHOSOM MED

JF - PSYCHOSOM MED

SN - 0033-3174

IS - 2

ER -