Dendritic mRNA targeting and translation.

Stefan Kindler; Hans-Jürgen Kreienkamp

Dendritic mRNA targeting and translation.

Standard

Dendritic mRNA targeting and translation. / Kindler, Stefan ; Kreienkamp, Hans-Jürgen.

in: ADV EXP MED BIOL, Jahrgang 970, 2012, S. 285-305.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kindler, S & Kreienkamp, H-J 2012, 'Dendritic mRNA targeting and translation.', ADV EXP MED BIOL, Jg. 970, S. 285-305. <http://www.ncbi.nlm.nih.gov/pubmed/22351061?dopt=Citation>

APA

Kindler, S., & Kreienkamp, H-J. (2012). Dendritic mRNA targeting and translation. ADV EXP MED BIOL, 970, 285-305. http://www.ncbi.nlm.nih.gov/pubmed/22351061?dopt=Citation

Vancouver

Kindler S , Kreienkamp H-J. Dendritic mRNA targeting and translation. ADV EXP MED BIOL. 2012;970:285-305.

Bibtex

@article{bd84e7552dcd4991aba52fed126bdcae,

title = "Dendritic mRNA targeting and translation.",

abstract = "Selective targeting of specific mRNAs into neuronal dendrites and their locally regulated translation at particular cell contact sites contribute to input-specific synaptic plasticity. Thus, individual synapses become decision-making units, which control gene expression in a spatially restricted and nucleus-independent manner. Dendritic targeting of mRNAs is achieved by active, microtubule-dependent transport. For this purpose, mRNAs are packaged into large ribonucleoprotein (RNP) particles containing an array of trans-acting RNA-binding proteins. These are attached to molecular motors, which move their RNP cargo into dendrites. A variety of proteins may be synthesized in dendrites, including signalling and scaffold proteins of the synapse and neurotransmitter receptors. In some cases, such as the alpha subunit of the calcium/calmodulin-dependent protein kinase II (?CaMKII) and the activity-regulated gene of 3.1 kb (Arg3.1, also referred to as activity-regulated cDNA, Arc), their local synthesis at synapses can modulate long-term changes in synaptic efficiency. Local dendritic translation is regulated by several signalling cascades including Akt/mTOR and Erk/MAP kinase pathways, which are triggered by synaptic activity. More recent findings show that miRNAs also play an important role in protein synthesis at synapses. Disruption of local translation control at synapses, as observed in the fragile X syndrome (FXS) and its mouse models and possibly also in autism spectrum disorders, interferes with cognitive abilities in mice and men.",

keywords = "Animals, Humans, Mice, MicroRNAs/genetics/metabolism, Long-Term Potentiation/physiology, Protein Biosynthesis/*physiology, Nerve Tissue Proteins/genetics/metabolism, Gene Expression Regulation/*physiology, Synapses/*physiology, Biological Transport, Active/physiology, Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics/metabolism, Cytoskeletal Proteins/genetics/metabolism, Dendrites/*genetics/metabolism, Extracellular Signal-Regulated MAP Kinases/genetics/metabolism, Fragile X Syndrome/genetics/metabolism/physiopathology, Molecular Motor Proteins/genetics/metabolism, RNA, Messenger/*genetics/metabolism, RNA-Binding Proteins/genetics/metabolism, Receptors, Neurotransmitter/genetics/metabolism, Signal Transduction/*genetics, TOR Serine-Threonine Kinases/genetics/metabolism, Animals, Humans, Mice, MicroRNAs/genetics/metabolism, Long-Term Potentiation/physiology, Protein Biosynthesis/*physiology, Nerve Tissue Proteins/genetics/metabolism, Gene Expression Regulation/*physiology, Synapses/*physiology, Biological Transport, Active/physiology, Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics/metabolism, Cytoskeletal Proteins/genetics/metabolism, Dendrites/*genetics/metabolism, Extracellular Signal-Regulated MAP Kinases/genetics/metabolism, Fragile X Syndrome/genetics/metabolism/physiopathology, Molecular Motor Proteins/genetics/metabolism, RNA, Messenger/*genetics/metabolism, RNA-Binding Proteins/genetics/metabolism, Receptors, Neurotransmitter/genetics/metabolism, Signal Transduction/*genetics, TOR Serine-Threonine Kinases/genetics/metabolism",

author = "Stefan Kindler and Hans-J{\"u}rgen Kreienkamp",

year = "2012",

language = "English",

volume = "970",

pages = "285--305",

journal = "ADV EXP MED BIOL",

issn = "0065-2598",

publisher = "Springer New York",

}

RIS

TY - JOUR

T1 - Dendritic mRNA targeting and translation.

AU - Kindler, Stefan

AU - Kreienkamp, Hans-Jürgen

PY - 2012

Y1 - 2012

N2 - Selective targeting of specific mRNAs into neuronal dendrites and their locally regulated translation at particular cell contact sites contribute to input-specific synaptic plasticity. Thus, individual synapses become decision-making units, which control gene expression in a spatially restricted and nucleus-independent manner. Dendritic targeting of mRNAs is achieved by active, microtubule-dependent transport. For this purpose, mRNAs are packaged into large ribonucleoprotein (RNP) particles containing an array of trans-acting RNA-binding proteins. These are attached to molecular motors, which move their RNP cargo into dendrites. A variety of proteins may be synthesized in dendrites, including signalling and scaffold proteins of the synapse and neurotransmitter receptors. In some cases, such as the alpha subunit of the calcium/calmodulin-dependent protein kinase II (?CaMKII) and the activity-regulated gene of 3.1 kb (Arg3.1, also referred to as activity-regulated cDNA, Arc), their local synthesis at synapses can modulate long-term changes in synaptic efficiency. Local dendritic translation is regulated by several signalling cascades including Akt/mTOR and Erk/MAP kinase pathways, which are triggered by synaptic activity. More recent findings show that miRNAs also play an important role in protein synthesis at synapses. Disruption of local translation control at synapses, as observed in the fragile X syndrome (FXS) and its mouse models and possibly also in autism spectrum disorders, interferes with cognitive abilities in mice and men.

AB - Selective targeting of specific mRNAs into neuronal dendrites and their locally regulated translation at particular cell contact sites contribute to input-specific synaptic plasticity. Thus, individual synapses become decision-making units, which control gene expression in a spatially restricted and nucleus-independent manner. Dendritic targeting of mRNAs is achieved by active, microtubule-dependent transport. For this purpose, mRNAs are packaged into large ribonucleoprotein (RNP) particles containing an array of trans-acting RNA-binding proteins. These are attached to molecular motors, which move their RNP cargo into dendrites. A variety of proteins may be synthesized in dendrites, including signalling and scaffold proteins of the synapse and neurotransmitter receptors. In some cases, such as the alpha subunit of the calcium/calmodulin-dependent protein kinase II (?CaMKII) and the activity-regulated gene of 3.1 kb (Arg3.1, also referred to as activity-regulated cDNA, Arc), their local synthesis at synapses can modulate long-term changes in synaptic efficiency. Local dendritic translation is regulated by several signalling cascades including Akt/mTOR and Erk/MAP kinase pathways, which are triggered by synaptic activity. More recent findings show that miRNAs also play an important role in protein synthesis at synapses. Disruption of local translation control at synapses, as observed in the fragile X syndrome (FXS) and its mouse models and possibly also in autism spectrum disorders, interferes with cognitive abilities in mice and men.

KW - Animals

KW - Humans

KW - Mice

KW - MicroRNAs/genetics/metabolism

KW - Long-Term Potentiation/physiology

KW - Protein Biosynthesis/physiology

KW - Nerve Tissue Proteins/genetics/metabolism

KW - Gene Expression Regulation/physiology

KW - Synapses/physiology

KW - Biological Transport, Active/physiology

KW - Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics/metabolism

KW - Cytoskeletal Proteins/genetics/metabolism

KW - Dendrites/genetics/metabolism

KW - Extracellular Signal-Regulated MAP Kinases/genetics/metabolism

KW - Fragile X Syndrome/genetics/metabolism/physiopathology

KW - Molecular Motor Proteins/genetics/metabolism

KW - RNA, Messenger/genetics/metabolism

KW - RNA-Binding Proteins/genetics/metabolism

KW - Receptors, Neurotransmitter/genetics/metabolism

KW - Signal Transduction/genetics

KW - TOR Serine-Threonine Kinases/genetics/metabolism