Dendritic Cells and Their Role in Cardiovascular Diseases: A View on Human Studies
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Dendritic Cells and Their Role in Cardiovascular Diseases: A View on Human Studies. / Dieterlen, Maja-Theresa; John, Katja; Reichenspurner, Hermann; Mohr, Friedrich W; Barten, Markus J.
in: J IMMUNOL RES, Jahrgang 2016, 2016, S. 5946807.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Dendritic Cells and Their Role in Cardiovascular Diseases: A View on Human Studies
AU - Dieterlen, Maja-Theresa
AU - John, Katja
AU - Reichenspurner, Hermann
AU - Mohr, Friedrich W
AU - Barten, Markus J
PY - 2016
Y1 - 2016
N2 - The antigen-presenting dendritic cells (DCs) are key to the immunological response, with different functions ascribed ranging from cellular immune activation to induction of tolerance. Such immunological responses are involved in the pathophysiological mechanisms of cardiovascular diseases, with DCs shown to play a role in atherosclerosis, hypertension, and heart failure and most notably following heart transplantation. A better understanding of the interplay between the immune system and cardiovascular diseases will therefore be critical for developing novel therapeutic treatments as well as innovative monitoring tools for disease progression. As such, the present review will provide an overview of DCs involvement in the pathophysiology of cardiovascular diseases and how targeting these cells may have beneficial effects for the prognosis of patients.
AB - The antigen-presenting dendritic cells (DCs) are key to the immunological response, with different functions ascribed ranging from cellular immune activation to induction of tolerance. Such immunological responses are involved in the pathophysiological mechanisms of cardiovascular diseases, with DCs shown to play a role in atherosclerosis, hypertension, and heart failure and most notably following heart transplantation. A better understanding of the interplay between the immune system and cardiovascular diseases will therefore be critical for developing novel therapeutic treatments as well as innovative monitoring tools for disease progression. As such, the present review will provide an overview of DCs involvement in the pathophysiology of cardiovascular diseases and how targeting these cells may have beneficial effects for the prognosis of patients.
KW - Antigen Presentation
KW - Antigens/immunology
KW - Atherosclerosis/immunology
KW - Clinical Trials as Topic
KW - Coronary Artery Bypass
KW - Dendritic Cells/immunology
KW - Heart Failure/immunology
KW - Heart Transplantation
KW - Humans
KW - Hypertension/immunology
KW - Immune Tolerance
KW - Immunity, Innate
U2 - 10.1155/2016/5946807
DO - 10.1155/2016/5946807
M3 - SCORING: Review article
C2 - 27088098
VL - 2016
SP - 5946807
JO - J IMMUNOL RES
JF - J IMMUNOL RES
SN - 2314-8861
ER -