Dementia and leukoencephalopathy due to lymphomatosis cerebri
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Dementia and leukoencephalopathy due to lymphomatosis cerebri. / Lewerenz, Jan; Ding, Xiao-Qi; Matschke, J; Schnabel, C; Emami, P; von Borczyskowski, D; Buchert, R; Krieger, T; de Wit, M; Münchau, A.
in: BMJ CASE REP, Jahrgang 2009, 01.01.2009.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Dementia and leukoencephalopathy due to lymphomatosis cerebri
AU - Lewerenz, Jan
AU - Ding, Xiao-Qi
AU - Matschke, J
AU - Schnabel, C
AU - Emami, P
AU - von Borczyskowski, D
AU - Buchert, R
AU - Krieger, T
AU - de Wit, M
AU - Münchau, A
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Lymphomatosis cerebri (LC) is a rare variant of primary central nervous system lymphoma (PCNSL). Clinically, the disease typically presents with a rapidly progressive dementia and unsteadiness of gait. Its presentation on cerebral MRI, which is characterised by diffuse leukoencephalopathy without contrast enhancement, often causes diagnostic confusion1 with suspected diagnoses ranging from Binswanger's disease to leukoencephalopathy or encephalomyelitis. Here we report a patient with subacute dementia and diffuse bilateral white matter changes in the cerebral hemispheres and additional involvement of the brainstem, basal ganglia and thalamus on MRI. Initially, she was considered to suffer from an autoimmune encephalitis, transiently responded to immunosuppression but then developed multiple solid appearing cerebral lymphomas.
AB - Lymphomatosis cerebri (LC) is a rare variant of primary central nervous system lymphoma (PCNSL). Clinically, the disease typically presents with a rapidly progressive dementia and unsteadiness of gait. Its presentation on cerebral MRI, which is characterised by diffuse leukoencephalopathy without contrast enhancement, often causes diagnostic confusion1 with suspected diagnoses ranging from Binswanger's disease to leukoencephalopathy or encephalomyelitis. Here we report a patient with subacute dementia and diffuse bilateral white matter changes in the cerebral hemispheres and additional involvement of the brainstem, basal ganglia and thalamus on MRI. Initially, she was considered to suffer from an autoimmune encephalitis, transiently responded to immunosuppression but then developed multiple solid appearing cerebral lymphomas.
U2 - 10.1136/bcr.08.2008.0752
DO - 10.1136/bcr.08.2008.0752
M3 - SCORING: Journal article
C2 - 21686648
VL - 2009
JO - BMJ CASE REP
JF - BMJ CASE REP
SN - 1757-790X
ER -