Deletion of chromosome band 13q14 as detected by fluorescence in situ hybridization is a prognostic factor in patients with multiple myeloma who are receiving allogeneic dose-reduced stem cell transplantation.
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Deletion of chromosome band 13q14 as detected by fluorescence in situ hybridization is a prognostic factor in patients with multiple myeloma who are receiving allogeneic dose-reduced stem cell transplantation. / Kröger, Nicolaus-Martin; Schilling, Georgia; Einsele, Hermann; Liebisch, Peter; Shimoni, Avichai; Nagler, Arnon; Perez-Simon, Jose A; Miguel, San; Jesus, F; Kiehl, Michael; Fauser, Axel; Schwerdtfeger, Rainer; Wandt, Hannes; Sayer, Herbert G; Myint, Han; Zabelina, Tatjana; Zabelina, Tatjana; Dierlamm, Judith; Hinke, Axel; Zander, Axel.
in: BLOOD, Jahrgang 103, Nr. 11, 11, 2004, S. 4056-4061.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Deletion of chromosome band 13q14 as detected by fluorescence in situ hybridization is a prognostic factor in patients with multiple myeloma who are receiving allogeneic dose-reduced stem cell transplantation.
AU - Kröger, Nicolaus-Martin
AU - Schilling, Georgia
AU - Einsele, Hermann
AU - Liebisch, Peter
AU - Shimoni, Avichai
AU - Nagler, Arnon
AU - Perez-Simon, Jose A
AU - Miguel, San
AU - Jesus, F
AU - Kiehl, Michael
AU - Fauser, Axel
AU - Schwerdtfeger, Rainer
AU - Wandt, Hannes
AU - Sayer, Herbert G
AU - Myint, Han
AU - Zabelina, Tatjana
AU - Zabelina, Tatjana
AU - Dierlamm, Judith
AU - Hinke, Axel
AU - Zander, Axel
PY - 2004
Y1 - 2004
N2 - We investigated in a retrospective multicenter study the impact of chromosome arm 13q deletion (13q-) as detected by fluorescence in situ hybridization (FISH) on outcome after dose-reduced allografting in patients with multiple myeloma. In 68 of 140 patients, data on chromosome 13q status were available. Most patients included had advanced myeloma. At 2 years, patients with 13q deletion (n = 31) had a shorter event-free (18% vs 42%; P =.05) and overall survival (18% vs 67%; P =.03) than patients without 13q- (n = 37). Patients with 13q- experienced a higher relapse rate (77% vs 44%; P
AB - We investigated in a retrospective multicenter study the impact of chromosome arm 13q deletion (13q-) as detected by fluorescence in situ hybridization (FISH) on outcome after dose-reduced allografting in patients with multiple myeloma. In 68 of 140 patients, data on chromosome 13q status were available. Most patients included had advanced myeloma. At 2 years, patients with 13q deletion (n = 31) had a shorter event-free (18% vs 42%; P =.05) and overall survival (18% vs 67%; P =.03) than patients without 13q- (n = 37). Patients with 13q- experienced a higher relapse rate (77% vs 44%; P
M3 - SCORING: Zeitschriftenaufsatz
VL - 103
SP - 4056
EP - 4061
JO - BLOOD
JF - BLOOD
SN - 0006-4971
IS - 11
M1 - 11
ER -