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Degrading devices: invadosomes in proteolytic cell invasion.

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Degrading devices: invadosomes in proteolytic cell invasion. / Linder, Stefan; Wiesner, Christiane; Himmel, Mirko.

in: ANNU REV CELL DEV BI, Jahrgang 27, 2011, S. 185-211.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Linder, S, Wiesner, C & Himmel, M 2011, 'Degrading devices: invadosomes in proteolytic cell invasion.', ANNU REV CELL DEV BI, Jg. 27, S. 185-211. <http://www.ncbi.nlm.nih.gov/pubmed/21801014?dopt=Citation>

APA

Linder, S., Wiesner, C., & Himmel, M. (2011). Degrading devices: invadosomes in proteolytic cell invasion. ANNU REV CELL DEV BI, 27, 185-211. http://www.ncbi.nlm.nih.gov/pubmed/21801014?dopt=Citation

Vancouver

Linder S, Wiesner C, Himmel M. Degrading devices: invadosomes in proteolytic cell invasion. ANNU REV CELL DEV BI. 2011;27:185-211.

Bibtex

@article{78d1f94f6de94ec2a813ff618b58f955,
title = "Degrading devices: invadosomes in proteolytic cell invasion.",
abstract = "Podosomes and invadopodia, collectively known as invadosomes, are cell-matrix contacts in a variety of cell types, such as monocytic cells or cancer cells, that have to cross tissue barriers. Both structures share an actin-rich core, which distinguishes them from other matrix contacts, and are regulated by a multitude of signaling pathways including RhoGTPases, kinases, actin-associated proteins, and microtubule-dependent transport. Invadosomes recruit and secrete proteinases and are thus able to lyse extracellular matrix components. They are therefore considered to be potential key structures in proteolytic cell invasion in both physiological and pathological settings. This review provides an overview of the field, with special focus on current developments such as intracellular transport processes, ultrastructural analysis, the possible involvement of invadosomes in disease, and the tentative identification of invadosomes in 3D environments and in vivo.",
keywords = "Animals, Cell Movement/*physiology, Cell Adhesion/physiology, Microtubules/metabolism, Signal Transduction/physiology, Actins/metabolism, Biological Transport/physiology, Cell Surface Extensions/*metabolism/ultrastructure, Cytoskeleton/metabolism, Extracellular Matrix/*metabolism, Myosins/metabolism, Organelles/metabolism/ultrastructure, Proteolysis, Animals, Cell Movement/*physiology, Cell Adhesion/physiology, Microtubules/metabolism, Signal Transduction/physiology, Actins/metabolism, Biological Transport/physiology, Cell Surface Extensions/*metabolism/ultrastructure, Cytoskeleton/metabolism, Extracellular Matrix/*metabolism, Myosins/metabolism, Organelles/metabolism/ultrastructure, Proteolysis",
author = "Stefan Linder and Christiane Wiesner and Mirko Himmel",
year = "2011",
language = "English",
volume = "27",
pages = "185--211",
journal = "ANNU REV CELL DEV BI",
issn = "1081-0706",
publisher = "Annual Reviews Inc.",

}

RIS

TY - JOUR

T1 - Degrading devices: invadosomes in proteolytic cell invasion.

AU - Linder, Stefan

AU - Wiesner, Christiane

AU - Himmel, Mirko

PY - 2011

Y1 - 2011

N2 - Podosomes and invadopodia, collectively known as invadosomes, are cell-matrix contacts in a variety of cell types, such as monocytic cells or cancer cells, that have to cross tissue barriers. Both structures share an actin-rich core, which distinguishes them from other matrix contacts, and are regulated by a multitude of signaling pathways including RhoGTPases, kinases, actin-associated proteins, and microtubule-dependent transport. Invadosomes recruit and secrete proteinases and are thus able to lyse extracellular matrix components. They are therefore considered to be potential key structures in proteolytic cell invasion in both physiological and pathological settings. This review provides an overview of the field, with special focus on current developments such as intracellular transport processes, ultrastructural analysis, the possible involvement of invadosomes in disease, and the tentative identification of invadosomes in 3D environments and in vivo.

AB - Podosomes and invadopodia, collectively known as invadosomes, are cell-matrix contacts in a variety of cell types, such as monocytic cells or cancer cells, that have to cross tissue barriers. Both structures share an actin-rich core, which distinguishes them from other matrix contacts, and are regulated by a multitude of signaling pathways including RhoGTPases, kinases, actin-associated proteins, and microtubule-dependent transport. Invadosomes recruit and secrete proteinases and are thus able to lyse extracellular matrix components. They are therefore considered to be potential key structures in proteolytic cell invasion in both physiological and pathological settings. This review provides an overview of the field, with special focus on current developments such as intracellular transport processes, ultrastructural analysis, the possible involvement of invadosomes in disease, and the tentative identification of invadosomes in 3D environments and in vivo.

KW - Animals

KW - Cell Movement/physiology

KW - Cell Adhesion/physiology

KW - Microtubules/metabolism

KW - Signal Transduction/physiology

KW - Actins/metabolism

KW - Biological Transport/physiology

KW - Cell Surface Extensions/metabolism/ultrastructure

KW - Cytoskeleton/metabolism

KW - Extracellular Matrix/metabolism

KW - Myosins/metabolism

KW - Organelles/metabolism/ultrastructure

KW - Proteolysis

KW - Animals

KW - Cell Movement/physiology

KW - Cell Adhesion/physiology

KW - Microtubules/metabolism

KW - Signal Transduction/physiology

KW - Actins/metabolism

KW - Biological Transport/physiology

KW - Cell Surface Extensions/metabolism/ultrastructure

KW - Cytoskeleton/metabolism

KW - Extracellular Matrix/metabolism

KW - Myosins/metabolism

KW - Organelles/metabolism/ultrastructure

KW - Proteolysis

M3 - SCORING: Journal article

VL - 27

SP - 185

EP - 211

JO - ANNU REV CELL DEV BI

JF - ANNU REV CELL DEV BI

SN - 1081-0706

ER -