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Degradation, Bone Regeneration and Tissue Response of an Innovative Volume Stable Magnesium-Supported GBR/GTR Barrier Membrane

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Degradation, Bone Regeneration and Tissue Response of an Innovative Volume Stable Magnesium-Supported GBR/GTR Barrier Membrane. / Barbeck, Mike; Kühnel, Lennart; Witte, Frank; Pissarek, Jens; Precht, Clarissa; Xiong, Xin; Krastev, Rumen; Wegner, Nils; Walther, Frank; Jung, Ole.

in: INT J MOL SCI, Jahrgang 21, Nr. 9, 28.04.2020.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Barbeck, M, Kühnel, L, Witte, F, Pissarek, J, Precht, C, Xiong, X, Krastev, R, Wegner, N, Walther, F & Jung, O 2020, 'Degradation, Bone Regeneration and Tissue Response of an Innovative Volume Stable Magnesium-Supported GBR/GTR Barrier Membrane', INT J MOL SCI, Jg. 21, Nr. 9. https://doi.org/10.3390/ijms21093098

APA

Barbeck, M., Kühnel, L., Witte, F., Pissarek, J., Precht, C., Xiong, X., Krastev, R., Wegner, N., Walther, F., & Jung, O. (2020). Degradation, Bone Regeneration and Tissue Response of an Innovative Volume Stable Magnesium-Supported GBR/GTR Barrier Membrane. INT J MOL SCI, 21(9). https://doi.org/10.3390/ijms21093098

Vancouver

Barbeck M, Kühnel L, Witte F, Pissarek J, Precht C, Xiong X et al. Degradation, Bone Regeneration and Tissue Response of an Innovative Volume Stable Magnesium-Supported GBR/GTR Barrier Membrane. INT J MOL SCI. 2020 Apr 28;21(9). https://doi.org/10.3390/ijms21093098

Bibtex

@article{53df6254908f4fff97a74ae9359f5c49,
title = "Degradation, Bone Regeneration and Tissue Response of an Innovative Volume Stable Magnesium-Supported GBR/GTR Barrier Membrane",
abstract = "INTRODUCTION: Bioresorbable collagenous barrier membranes are used to prevent premature soft tissue ingrowth and to allow bone regeneration. For volume stable indications, only non-absorbable synthetic materials are available. This study investigates a new bioresorbable hydrofluoric acid (HF)-treated magnesium (Mg) mesh in a native collagen membrane for volume stable situations.MATERIALS AND METHODS: HF-treated and untreated Mg were compared in direct and indirect cytocompatibility assays. In vivo, 18 New Zealand White Rabbits received each four 8 mm calvarial defects and were divided into four groups: (a) HF-treated Mg mesh/collagen membrane, (b) untreated Mg mesh/collagen membrane (c) collagen membrane and (d) sham operation. After 6, 12 and 18 weeks, Mg degradation and bone regeneration was measured using radiological and histological methods.RESULTS: In vitro, HF-treated Mg showed higher cytocompatibility. Histopathologically, HF-Mg prevented gas cavities and was degraded by mononuclear cells via phagocytosis up to 12 weeks. Untreated Mg showed partially significant more gas cavities and a fibrous tissue reaction. Bone regeneration was not significantly different between all groups.DISCUSSION AND CONCLUSIONS: HF-Mg meshes embedded in native collagen membranes represent a volume stable and biocompatible alternative to the non-absorbable synthetic materials. HF-Mg shows less corrosion and is degraded by phagocytosis. However, the application of membranes did not result in higher bone regeneration.",
keywords = "3T3 Cells, Absorbable Implants, Animals, Biocompatible Materials/chemistry, Bone Regeneration/drug effects, Cell Line, Disease Models, Animal, Female, Guided Tissue Regeneration, Hydrofluoric Acid/chemistry, Magnesium/chemistry, Membranes, Artificial, Mice, Phagocytosis, Rabbits, Skull/drug effects, Treatment Outcome",
author = "Mike Barbeck and Lennart K{\"u}hnel and Frank Witte and Jens Pissarek and Clarissa Precht and Xin Xiong and Rumen Krastev and Nils Wegner and Frank Walther and Ole Jung",
year = "2020",
month = apr,
day = "28",
doi = "10.3390/ijms21093098",
language = "English",
volume = "21",
journal = "INT J MOL SCI",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "9",

}

RIS

TY - JOUR

T1 - Degradation, Bone Regeneration and Tissue Response of an Innovative Volume Stable Magnesium-Supported GBR/GTR Barrier Membrane

AU - Barbeck, Mike

AU - Kühnel, Lennart

AU - Witte, Frank

AU - Pissarek, Jens

AU - Precht, Clarissa

AU - Xiong, Xin

AU - Krastev, Rumen

AU - Wegner, Nils

AU - Walther, Frank

AU - Jung, Ole

PY - 2020/4/28

Y1 - 2020/4/28

N2 - INTRODUCTION: Bioresorbable collagenous barrier membranes are used to prevent premature soft tissue ingrowth and to allow bone regeneration. For volume stable indications, only non-absorbable synthetic materials are available. This study investigates a new bioresorbable hydrofluoric acid (HF)-treated magnesium (Mg) mesh in a native collagen membrane for volume stable situations.MATERIALS AND METHODS: HF-treated and untreated Mg were compared in direct and indirect cytocompatibility assays. In vivo, 18 New Zealand White Rabbits received each four 8 mm calvarial defects and were divided into four groups: (a) HF-treated Mg mesh/collagen membrane, (b) untreated Mg mesh/collagen membrane (c) collagen membrane and (d) sham operation. After 6, 12 and 18 weeks, Mg degradation and bone regeneration was measured using radiological and histological methods.RESULTS: In vitro, HF-treated Mg showed higher cytocompatibility. Histopathologically, HF-Mg prevented gas cavities and was degraded by mononuclear cells via phagocytosis up to 12 weeks. Untreated Mg showed partially significant more gas cavities and a fibrous tissue reaction. Bone regeneration was not significantly different between all groups.DISCUSSION AND CONCLUSIONS: HF-Mg meshes embedded in native collagen membranes represent a volume stable and biocompatible alternative to the non-absorbable synthetic materials. HF-Mg shows less corrosion and is degraded by phagocytosis. However, the application of membranes did not result in higher bone regeneration.

AB - INTRODUCTION: Bioresorbable collagenous barrier membranes are used to prevent premature soft tissue ingrowth and to allow bone regeneration. For volume stable indications, only non-absorbable synthetic materials are available. This study investigates a new bioresorbable hydrofluoric acid (HF)-treated magnesium (Mg) mesh in a native collagen membrane for volume stable situations.MATERIALS AND METHODS: HF-treated and untreated Mg were compared in direct and indirect cytocompatibility assays. In vivo, 18 New Zealand White Rabbits received each four 8 mm calvarial defects and were divided into four groups: (a) HF-treated Mg mesh/collagen membrane, (b) untreated Mg mesh/collagen membrane (c) collagen membrane and (d) sham operation. After 6, 12 and 18 weeks, Mg degradation and bone regeneration was measured using radiological and histological methods.RESULTS: In vitro, HF-treated Mg showed higher cytocompatibility. Histopathologically, HF-Mg prevented gas cavities and was degraded by mononuclear cells via phagocytosis up to 12 weeks. Untreated Mg showed partially significant more gas cavities and a fibrous tissue reaction. Bone regeneration was not significantly different between all groups.DISCUSSION AND CONCLUSIONS: HF-Mg meshes embedded in native collagen membranes represent a volume stable and biocompatible alternative to the non-absorbable synthetic materials. HF-Mg shows less corrosion and is degraded by phagocytosis. However, the application of membranes did not result in higher bone regeneration.

KW - 3T3 Cells

KW - Absorbable Implants

KW - Animals

KW - Biocompatible Materials/chemistry

KW - Bone Regeneration/drug effects

KW - Cell Line

KW - Disease Models, Animal

KW - Female

KW - Guided Tissue Regeneration

KW - Hydrofluoric Acid/chemistry

KW - Magnesium/chemistry

KW - Membranes, Artificial

KW - Mice

KW - Phagocytosis

KW - Rabbits

KW - Skull/drug effects

KW - Treatment Outcome

U2 - 10.3390/ijms21093098

DO - 10.3390/ijms21093098

M3 - SCORING: Journal article

C2 - 32353983

VL - 21

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 9

ER -