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Decreased regulatory T cells in vulnerable atherosclerotic lesions

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Decreased regulatory T cells in vulnerable atherosclerotic lesions : imbalance between pro- and anti-inflammatory cells in atherosclerosis. / Rohm, Ilonka; Atiskova, Yevgeniya; Drobnik, Stefanie; Fritzenwanger, Michael; Kretzschmar, Daniel; Pistulli, Rudin; Zanow, Jürgen; Krönert, Thomas; Mall, Gita; Figulla, Hans Reiner; Yilmaz, Atilla.

in: MEDIAT INFLAMM, Jahrgang 2015, 2015, S. 364710.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rohm, I, Atiskova, Y, Drobnik, S, Fritzenwanger, M, Kretzschmar, D, Pistulli, R, Zanow, J, Krönert, T, Mall, G, Figulla, HR & Yilmaz, A 2015, 'Decreased regulatory T cells in vulnerable atherosclerotic lesions: imbalance between pro- and anti-inflammatory cells in atherosclerosis', MEDIAT INFLAMM, Jg. 2015, S. 364710. https://doi.org/10.1155/2015/364710

APA

Rohm, I., Atiskova, Y., Drobnik, S., Fritzenwanger, M., Kretzschmar, D., Pistulli, R., Zanow, J., Krönert, T., Mall, G., Figulla, H. R., & Yilmaz, A. (2015). Decreased regulatory T cells in vulnerable atherosclerotic lesions: imbalance between pro- and anti-inflammatory cells in atherosclerosis. MEDIAT INFLAMM, 2015, 364710. https://doi.org/10.1155/2015/364710

Vancouver

Rohm I, Atiskova Y, Drobnik S, Fritzenwanger M, Kretzschmar D, Pistulli R et al. Decreased regulatory T cells in vulnerable atherosclerotic lesions: imbalance between pro- and anti-inflammatory cells in atherosclerosis. MEDIAT INFLAMM. 2015;2015:364710. https://doi.org/10.1155/2015/364710

Bibtex

@article{2dfe9cc24f9e47b699ee462b29bdaa00,
title = "Decreased regulatory T cells in vulnerable atherosclerotic lesions: imbalance between pro- and anti-inflammatory cells in atherosclerosis",
abstract = "Atherosclerosis is a chronic inflammatory disease of the arterial wall in which presentation of autoantigens by dendritic cells (DCs) leads to the activation of T cells. Anti-inflammatory cells like Tregs counterbalance inflammation in atherogenesis. In our study, human carotid plaque specimens were classified as stable (14) and unstable (15) according to established morphological criteria. Vessel specimens (n = 12) without any signs of atherosclerosis were used as controls. Immunohistochemical staining was performed to detect different types of DCs (S100, fascin, CD83, CD209, CD304, and CD123), proinflammatory T cells (CD3, CD4, CD8, and CD161), and anti-inflammatory Tregs (FoxP3). The following results were observed: in unstable lesions, significantly higher numbers of proinflammatory cells like DCs, T helper cells, cytotoxic T cells, and natural killer cells were detected compared to stable plaques. Additionally, there was a significantly higher expression of HLA-DR and more T cell activation (CD25, CD69) in unstable lesions. On the contrary, unstable lesions contained significantly lower numbers of Tregs. Furthermore, a significant inverse correlation between myeloid DCs and Tregs was shown. These data suggest an increased inflammatory state in vulnerable plaques resulting from an imbalance of the frequency of local pro- and anti-inflammatory immune cells.",
keywords = "Aged, Antigens, CD/metabolism, Atherosclerosis/immunology, Carrier Proteins/metabolism, Female, Forkhead Transcription Factors/metabolism, Humans, Inflammation/immunology, Killer Cells, Natural/metabolism, Lymphocyte Activation, Male, Microfilament Proteins/metabolism, Middle Aged, T-Lymphocytes, Cytotoxic/metabolism, T-Lymphocytes, Helper-Inducer/metabolism, T-Lymphocytes, Regulatory/immunology",
author = "Ilonka Rohm and Yevgeniya Atiskova and Stefanie Drobnik and Michael Fritzenwanger and Daniel Kretzschmar and Rudin Pistulli and J{\"u}rgen Zanow and Thomas Kr{\"o}nert and Gita Mall and Figulla, {Hans Reiner} and Atilla Yilmaz",
year = "2015",
doi = "10.1155/2015/364710",
language = "English",
volume = "2015",
pages = "364710",
journal = "MEDIAT INFLAMM",
issn = "0962-9351",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Decreased regulatory T cells in vulnerable atherosclerotic lesions

T2 - imbalance between pro- and anti-inflammatory cells in atherosclerosis

AU - Rohm, Ilonka

AU - Atiskova, Yevgeniya

AU - Drobnik, Stefanie

AU - Fritzenwanger, Michael

AU - Kretzschmar, Daniel

AU - Pistulli, Rudin

AU - Zanow, Jürgen

AU - Krönert, Thomas

AU - Mall, Gita

AU - Figulla, Hans Reiner

AU - Yilmaz, Atilla

PY - 2015

Y1 - 2015

N2 - Atherosclerosis is a chronic inflammatory disease of the arterial wall in which presentation of autoantigens by dendritic cells (DCs) leads to the activation of T cells. Anti-inflammatory cells like Tregs counterbalance inflammation in atherogenesis. In our study, human carotid plaque specimens were classified as stable (14) and unstable (15) according to established morphological criteria. Vessel specimens (n = 12) without any signs of atherosclerosis were used as controls. Immunohistochemical staining was performed to detect different types of DCs (S100, fascin, CD83, CD209, CD304, and CD123), proinflammatory T cells (CD3, CD4, CD8, and CD161), and anti-inflammatory Tregs (FoxP3). The following results were observed: in unstable lesions, significantly higher numbers of proinflammatory cells like DCs, T helper cells, cytotoxic T cells, and natural killer cells were detected compared to stable plaques. Additionally, there was a significantly higher expression of HLA-DR and more T cell activation (CD25, CD69) in unstable lesions. On the contrary, unstable lesions contained significantly lower numbers of Tregs. Furthermore, a significant inverse correlation between myeloid DCs and Tregs was shown. These data suggest an increased inflammatory state in vulnerable plaques resulting from an imbalance of the frequency of local pro- and anti-inflammatory immune cells.

AB - Atherosclerosis is a chronic inflammatory disease of the arterial wall in which presentation of autoantigens by dendritic cells (DCs) leads to the activation of T cells. Anti-inflammatory cells like Tregs counterbalance inflammation in atherogenesis. In our study, human carotid plaque specimens were classified as stable (14) and unstable (15) according to established morphological criteria. Vessel specimens (n = 12) without any signs of atherosclerosis were used as controls. Immunohistochemical staining was performed to detect different types of DCs (S100, fascin, CD83, CD209, CD304, and CD123), proinflammatory T cells (CD3, CD4, CD8, and CD161), and anti-inflammatory Tregs (FoxP3). The following results were observed: in unstable lesions, significantly higher numbers of proinflammatory cells like DCs, T helper cells, cytotoxic T cells, and natural killer cells were detected compared to stable plaques. Additionally, there was a significantly higher expression of HLA-DR and more T cell activation (CD25, CD69) in unstable lesions. On the contrary, unstable lesions contained significantly lower numbers of Tregs. Furthermore, a significant inverse correlation between myeloid DCs and Tregs was shown. These data suggest an increased inflammatory state in vulnerable plaques resulting from an imbalance of the frequency of local pro- and anti-inflammatory immune cells.

KW - Aged

KW - Antigens, CD/metabolism

KW - Atherosclerosis/immunology

KW - Carrier Proteins/metabolism

KW - Female

KW - Forkhead Transcription Factors/metabolism

KW - Humans

KW - Inflammation/immunology

KW - Killer Cells, Natural/metabolism

KW - Lymphocyte Activation

KW - Male

KW - Microfilament Proteins/metabolism

KW - Middle Aged

KW - T-Lymphocytes, Cytotoxic/metabolism

KW - T-Lymphocytes, Helper-Inducer/metabolism

KW - T-Lymphocytes, Regulatory/immunology

U2 - 10.1155/2015/364710

DO - 10.1155/2015/364710

M3 - SCORING: Journal article

C2 - 25684861

VL - 2015

SP - 364710

JO - MEDIAT INFLAMM

JF - MEDIAT INFLAMM

SN - 0962-9351

ER -