Decreased mismatch negativity and elevated frontal-lateral connectivity in first-episode psychosis
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Decreased mismatch negativity and elevated frontal-lateral connectivity in first-episode psychosis. / Yüksel, Mahmut; Murphy, Michael; Rippe, Jaelin; Leicht, Gregor; Öngür, Dost.
in: J PSYCHIATR RES, Jahrgang 144, 12.2021, S. 37-44.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Decreased mismatch negativity and elevated frontal-lateral connectivity in first-episode psychosis
AU - Yüksel, Mahmut
AU - Murphy, Michael
AU - Rippe, Jaelin
AU - Leicht, Gregor
AU - Öngür, Dost
N1 - Copyright © 2021 Elsevier Ltd. All rights reserved.
PY - 2021/12
Y1 - 2021/12
N2 - Decreased mismatch negativity (MMN) is a proposed biomarker for psychotic disorders. However, the magnitude of the effect appears to be attenuated in first-episode populations. Furthermore, how mismatch negativity amplitudes are related to brain connectivity in this population is unclear. In this study, we used high-density EEG to record duration-deviant MMN from 22 patients with first-episode psychosis (FEP) and 23 age-matched controls (HC). Consistent with past work, we found decreased MMN amplitude in FEP over a large area of the frontal scalp. We also found decreased latency over the occipital scalp. MMN amplitude was negatively correlated with antipsychotic dose. We used Granger causality to investigate directional connectivity between frontal, midline, left, and right scalp during MMN and found reduced connectivity in FEP compared to HC and following deviant stimuli compared to standard stimuli. FEP participants with smaller decreases in connectivity from standard to deviant stimuli had worse disorganization symptoms. On the other hand, connectivity from the front of the scalp following deviant stimuli was relatively preserved in FEP compared to controls. Our results suggest that a relative imbalance of bottom-up and top-down perceptual processing is present in the early stages of psychotic disorders.
AB - Decreased mismatch negativity (MMN) is a proposed biomarker for psychotic disorders. However, the magnitude of the effect appears to be attenuated in first-episode populations. Furthermore, how mismatch negativity amplitudes are related to brain connectivity in this population is unclear. In this study, we used high-density EEG to record duration-deviant MMN from 22 patients with first-episode psychosis (FEP) and 23 age-matched controls (HC). Consistent with past work, we found decreased MMN amplitude in FEP over a large area of the frontal scalp. We also found decreased latency over the occipital scalp. MMN amplitude was negatively correlated with antipsychotic dose. We used Granger causality to investigate directional connectivity between frontal, midline, left, and right scalp during MMN and found reduced connectivity in FEP compared to HC and following deviant stimuli compared to standard stimuli. FEP participants with smaller decreases in connectivity from standard to deviant stimuli had worse disorganization symptoms. On the other hand, connectivity from the front of the scalp following deviant stimuli was relatively preserved in FEP compared to controls. Our results suggest that a relative imbalance of bottom-up and top-down perceptual processing is present in the early stages of psychotic disorders.
U2 - 10.1016/j.jpsychires.2021.09.034
DO - 10.1016/j.jpsychires.2021.09.034
M3 - SCORING: Journal article
C2 - 34592510
VL - 144
SP - 37
EP - 44
JO - J PSYCHIATR RES
JF - J PSYCHIATR RES
SN - 0022-3956
ER -
