Deciphering Phosphotyrosine-Dependent Signaling Networks in Cancer by SH2 Profiling.
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Deciphering Phosphotyrosine-Dependent Signaling Networks in Cancer by SH2 Profiling. / Machida, Kazuya; Khenkhar, Malik; Nollau, Peter.
in: Genes Cancer, Jahrgang 3, Nr. 5-6, 5-6, 2012, S. 353-361.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Deciphering Phosphotyrosine-Dependent Signaling Networks in Cancer by SH2 Profiling.
AU - Machida, Kazuya
AU - Khenkhar, Malik
AU - Nollau, Peter
PY - 2012
Y1 - 2012
N2 - It has been a decade since the introduction of SH2 profiling, a modular domain-based molecular diagnostics tool. This review covers the original concept of SH2 profiling, different analytical platforms, and their applications, from the detailed analysis of single proteins to broad screening in translational research. Illustrated by practical examples, we discuss the uniqueness and advantages of the approach as well as its limitations and challenges. We provide guidance for basic researchers and oncologists who may consider SH2 profiling in their respective cancer research, especially for those focusing on tyrosine phosphoproteomics. SH2 profiling can serve as an alternative phosphoproteomics tool to dissect aberrant tyrosine kinase pathways responsible for individual malignancies, with the goal of facilitating personalized diagnostics for the treatment of cancer.
AB - It has been a decade since the introduction of SH2 profiling, a modular domain-based molecular diagnostics tool. This review covers the original concept of SH2 profiling, different analytical platforms, and their applications, from the detailed analysis of single proteins to broad screening in translational research. Illustrated by practical examples, we discuss the uniqueness and advantages of the approach as well as its limitations and challenges. We provide guidance for basic researchers and oncologists who may consider SH2 profiling in their respective cancer research, especially for those focusing on tyrosine phosphoproteomics. SH2 profiling can serve as an alternative phosphoproteomics tool to dissect aberrant tyrosine kinase pathways responsible for individual malignancies, with the goal of facilitating personalized diagnostics for the treatment of cancer.
M3 - SCORING: Journal article
VL - 3
SP - 353
EP - 361
JO - Genes Cancer
JF - Genes Cancer
SN - 1947-6019
IS - 5-6
M1 - 5-6
ER -
