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De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

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De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health. / Eissing, Leah; Scherer, Thomas; Tödter, Klaus; Knippschild, Uwe; Greve, Jan Willem; Buurman, Wim A; Pinnschmidt, Hans O; Rensen, Sander S; Wolf, Anna M; Bartelt, Alexander; Heeren, Joerg; Buettner, Christoph; Scheja, Ludger.

in: NAT COMMUN, Jahrgang 4, 01.01.2013, S. 1528.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Eissing, L, Scherer, T, Tödter, K, Knippschild, U, Greve, JW, Buurman, WA, Pinnschmidt, HO, Rensen, SS, Wolf, AM, Bartelt, A, Heeren, J, Buettner, C & Scheja, L 2013, 'De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health', NAT COMMUN, Jg. 4, S. 1528. https://doi.org/10.1038/ncomms2537

APA

Eissing, L., Scherer, T., Tödter, K., Knippschild, U., Greve, J. W., Buurman, W. A., Pinnschmidt, H. O., Rensen, S. S., Wolf, A. M., Bartelt, A., Heeren, J., Buettner, C., & Scheja, L. (2013). De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health. NAT COMMUN, 4, 1528. https://doi.org/10.1038/ncomms2537

Vancouver

Eissing L, Scherer T, Tödter K, Knippschild U, Greve JW, Buurman WA et al. De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health. NAT COMMUN. 2013 Jan 1;4:1528. https://doi.org/10.1038/ncomms2537

Bibtex

@article{89882f7462774af2a7b4d89fe7936f03,
title = "De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health",
abstract = "Clinical interest in de novo lipogenesis has been sparked by recent studies in rodents demonstrating that de novo lipogenesis specifically in white adipose tissue produces the insulin-sensitizing fatty acid palmitoleate. By contrast, hepatic lipogenesis is thought to contribute to metabolic disease. How de novo lipogenesis in white adipose tissue versus liver is altered in human obesity and insulin resistance is poorly understood. Here we show that lipogenic enzymes and the glucose transporter-4 are markedly decreased in white adipose tissue of insulin-resistant obese individuals compared with non-obese controls. By contrast, lipogenic enzymes are substantially upregulated in the liver of obese subjects. Bariatric weight loss restored de novo lipogenesis and glucose transporter-4 gene expression in white adipose tissue. Notably, lipogenic gene expression in both white adipose tissue and liver was strongly linked to the expression of carbohydrate-responsive element-binding protein-β and to metabolic risk markers. Thus, de novo lipogenesis predicts metabolic health in humans in a tissue-specific manner and is likely regulated by glucose-dependent carbohydrate-responsive element-binding protein activation.",
keywords = "Adiposity, Adult, Bariatric Surgery, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Body Mass Index, Fatty Acid Synthases, Fatty Acids, Fatty Liver, Female, Gene Dosage, Gene Expression Regulation, Glucose Transporter Type 4, Health, Humans, Insulin Resistance, Intra-Abdominal Fat, Lipogenesis, Liver, Male, Middle Aged, Obesity, RNA, Messenger, Risk Factors, Subcutaneous Fat, Tumor Necrosis Factor-alpha",
author = "Leah Eissing and Thomas Scherer and Klaus T{\"o}dter and Uwe Knippschild and Greve, {Jan Willem} and Buurman, {Wim A} and Pinnschmidt, {Hans O} and Rensen, {Sander S} and Wolf, {Anna M} and Alexander Bartelt and Joerg Heeren and Christoph Buettner and Ludger Scheja",
year = "2013",
month = jan,
day = "1",
doi = "10.1038/ncomms2537",
language = "English",
volume = "4",
pages = "1528",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

AU - Eissing, Leah

AU - Scherer, Thomas

AU - Tödter, Klaus

AU - Knippschild, Uwe

AU - Greve, Jan Willem

AU - Buurman, Wim A

AU - Pinnschmidt, Hans O

AU - Rensen, Sander S

AU - Wolf, Anna M

AU - Bartelt, Alexander

AU - Heeren, Joerg

AU - Buettner, Christoph

AU - Scheja, Ludger

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Clinical interest in de novo lipogenesis has been sparked by recent studies in rodents demonstrating that de novo lipogenesis specifically in white adipose tissue produces the insulin-sensitizing fatty acid palmitoleate. By contrast, hepatic lipogenesis is thought to contribute to metabolic disease. How de novo lipogenesis in white adipose tissue versus liver is altered in human obesity and insulin resistance is poorly understood. Here we show that lipogenic enzymes and the glucose transporter-4 are markedly decreased in white adipose tissue of insulin-resistant obese individuals compared with non-obese controls. By contrast, lipogenic enzymes are substantially upregulated in the liver of obese subjects. Bariatric weight loss restored de novo lipogenesis and glucose transporter-4 gene expression in white adipose tissue. Notably, lipogenic gene expression in both white adipose tissue and liver was strongly linked to the expression of carbohydrate-responsive element-binding protein-β and to metabolic risk markers. Thus, de novo lipogenesis predicts metabolic health in humans in a tissue-specific manner and is likely regulated by glucose-dependent carbohydrate-responsive element-binding protein activation.

AB - Clinical interest in de novo lipogenesis has been sparked by recent studies in rodents demonstrating that de novo lipogenesis specifically in white adipose tissue produces the insulin-sensitizing fatty acid palmitoleate. By contrast, hepatic lipogenesis is thought to contribute to metabolic disease. How de novo lipogenesis in white adipose tissue versus liver is altered in human obesity and insulin resistance is poorly understood. Here we show that lipogenic enzymes and the glucose transporter-4 are markedly decreased in white adipose tissue of insulin-resistant obese individuals compared with non-obese controls. By contrast, lipogenic enzymes are substantially upregulated in the liver of obese subjects. Bariatric weight loss restored de novo lipogenesis and glucose transporter-4 gene expression in white adipose tissue. Notably, lipogenic gene expression in both white adipose tissue and liver was strongly linked to the expression of carbohydrate-responsive element-binding protein-β and to metabolic risk markers. Thus, de novo lipogenesis predicts metabolic health in humans in a tissue-specific manner and is likely regulated by glucose-dependent carbohydrate-responsive element-binding protein activation.

KW - Adiposity

KW - Adult

KW - Bariatric Surgery

KW - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

KW - Body Mass Index

KW - Fatty Acid Synthases

KW - Fatty Acids

KW - Fatty Liver

KW - Female

KW - Gene Dosage

KW - Gene Expression Regulation

KW - Glucose Transporter Type 4

KW - Health

KW - Humans

KW - Insulin Resistance

KW - Intra-Abdominal Fat

KW - Lipogenesis

KW - Liver

KW - Male

KW - Middle Aged

KW - Obesity

KW - RNA, Messenger

KW - Risk Factors

KW - Subcutaneous Fat

KW - Tumor Necrosis Factor-alpha

U2 - 10.1038/ncomms2537

DO - 10.1038/ncomms2537

M3 - SCORING: Journal article

C2 - 23443556

VL - 4

SP - 1528

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

ER -