Data-Driven Classification of Spectral Profiles Reveals Brain Region-Specific Plasticity in Blindness
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Data-Driven Classification of Spectral Profiles Reveals Brain Region-Specific Plasticity in Blindness. / Lubinus, Christina; Orpella, Joan; Keitel, Anne; Gudi-Mindermann, Helene; Engel, Andreas K; Roeder, Brigitte; Rimmele, Johanna M.
in: CEREB CORTEX, Jahrgang 31, Nr. 5, 31.03.2021, S. 2505-2522.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Data-Driven Classification of Spectral Profiles Reveals Brain Region-Specific Plasticity in Blindness
AU - Lubinus, Christina
AU - Orpella, Joan
AU - Keitel, Anne
AU - Gudi-Mindermann, Helene
AU - Engel, Andreas K
AU - Roeder, Brigitte
AU - Rimmele, Johanna M
N1 - © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.
PY - 2021/3/31
Y1 - 2021/3/31
N2 - Congenital blindness has been shown to result in behavioral adaptation and neuronal reorganization, but the underlying neuronal mechanisms are largely unknown. Brain rhythms are characteristic for anatomically defined brain regions and provide a putative mechanistic link to cognitive processes. In a novel approach, using magnetoencephalography resting state data of congenitally blind and sighted humans, deprivation-related changes in spectral profiles were mapped to the cortex using clustering and classification procedures. Altered spectral profiles in visual areas suggest changes in visual alpha-gamma band inhibitory-excitatory circuits. Remarkably, spectral profiles were also altered in auditory and right frontal areas showing increased power in theta-to-beta frequency bands in blind compared with sighted individuals, possibly related to adaptive auditory and higher cognitive processing. Moreover, occipital alpha correlated with microstructural white matter properties extending bilaterally across posterior parts of the brain. We provide evidence that visual deprivation selectively modulates spectral profiles, possibly reflecting structural and functional adaptation.
AB - Congenital blindness has been shown to result in behavioral adaptation and neuronal reorganization, but the underlying neuronal mechanisms are largely unknown. Brain rhythms are characteristic for anatomically defined brain regions and provide a putative mechanistic link to cognitive processes. In a novel approach, using magnetoencephalography resting state data of congenitally blind and sighted humans, deprivation-related changes in spectral profiles were mapped to the cortex using clustering and classification procedures. Altered spectral profiles in visual areas suggest changes in visual alpha-gamma band inhibitory-excitatory circuits. Remarkably, spectral profiles were also altered in auditory and right frontal areas showing increased power in theta-to-beta frequency bands in blind compared with sighted individuals, possibly related to adaptive auditory and higher cognitive processing. Moreover, occipital alpha correlated with microstructural white matter properties extending bilaterally across posterior parts of the brain. We provide evidence that visual deprivation selectively modulates spectral profiles, possibly reflecting structural and functional adaptation.
U2 - 10.1093/cercor/bhaa370
DO - 10.1093/cercor/bhaa370
M3 - SCORING: Journal article
C2 - 33338212
VL - 31
SP - 2505
EP - 2522
JO - CEREB CORTEX
JF - CEREB CORTEX
SN - 1047-3211
IS - 5
ER -
