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Danger signals in stroke and their role on microglia activation after ischemia

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Danger signals in stroke and their role on microglia activation after ischemia. / Gülke, Eileen; Gelderblom, Mathias; Magnus, Tim.

in: THER ADV NEUROL DISO, Jahrgang 11, 2018, S. 1-14.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Gülke, E, Gelderblom, M & Magnus, T 2018, 'Danger signals in stroke and their role on microglia activation after ischemia', THER ADV NEUROL DISO, Jg. 11, S. 1-14. https://doi.org/10.1177/1756286418774254

APA

Gülke, E., Gelderblom, M., & Magnus, T. (2018). Danger signals in stroke and their role on microglia activation after ischemia. THER ADV NEUROL DISO, 11, 1-14. https://doi.org/10.1177/1756286418774254

Vancouver

Gülke E, Gelderblom M, Magnus T. Danger signals in stroke and their role on microglia activation after ischemia. THER ADV NEUROL DISO. 2018;11:1-14. https://doi.org/10.1177/1756286418774254

Bibtex

@article{9e450f0e262241f4bc60d4634ec9f620,
title = "Danger signals in stroke and their role on microglia activation after ischemia",
abstract = "Ischemic stroke is a major cause of death. Besides the direct damage resulting from oxygen and glucose deprivation, sterile inflammation plays a pivotal role in increasing cellular death. Damaged-associated molecular patterns (DAMPs) are passively released from dying cells and activate the innate immune system. Thus, they take part in the direct and rapid activation of the inflammatory response after stroke onset. In this review the role of the most important DAMPs, high mobility group box 1, heat and cold shock proteins, purines, and peroxiredoxins, are addressed. Moreover, intracellular pathways activated by DAMPs in microglia are illuminated.",
keywords = "Journal Article, Review",
author = "Eileen G{\"u}lke and Mathias Gelderblom and Tim Magnus",
year = "2018",
doi = "10.1177/1756286418774254",
language = "English",
volume = "11",
pages = "1--14",
journal = "THER ADV NEUROL DISO",
issn = "1756-2856",
publisher = "SAGE Publications",

}

RIS

TY - JOUR

T1 - Danger signals in stroke and their role on microglia activation after ischemia

AU - Gülke, Eileen

AU - Gelderblom, Mathias

AU - Magnus, Tim

PY - 2018

Y1 - 2018

N2 - Ischemic stroke is a major cause of death. Besides the direct damage resulting from oxygen and glucose deprivation, sterile inflammation plays a pivotal role in increasing cellular death. Damaged-associated molecular patterns (DAMPs) are passively released from dying cells and activate the innate immune system. Thus, they take part in the direct and rapid activation of the inflammatory response after stroke onset. In this review the role of the most important DAMPs, high mobility group box 1, heat and cold shock proteins, purines, and peroxiredoxins, are addressed. Moreover, intracellular pathways activated by DAMPs in microglia are illuminated.

AB - Ischemic stroke is a major cause of death. Besides the direct damage resulting from oxygen and glucose deprivation, sterile inflammation plays a pivotal role in increasing cellular death. Damaged-associated molecular patterns (DAMPs) are passively released from dying cells and activate the innate immune system. Thus, they take part in the direct and rapid activation of the inflammatory response after stroke onset. In this review the role of the most important DAMPs, high mobility group box 1, heat and cold shock proteins, purines, and peroxiredoxins, are addressed. Moreover, intracellular pathways activated by DAMPs in microglia are illuminated.

KW - Journal Article

KW - Review

U2 - 10.1177/1756286418774254

DO - 10.1177/1756286418774254

M3 - SCORING: Review article

C2 - 29854002

VL - 11

SP - 1

EP - 14

JO - THER ADV NEUROL DISO

JF - THER ADV NEUROL DISO

SN - 1756-2856

ER -