Danger signals in stroke
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Danger signals in stroke. / Gelderblom, Mathias; Sobey, Christopher G; Kleinschnitz, Christoph; Magnus, Tim.
in: AGEING RES REV, Jahrgang 24, Nr. Pt A, Special Issue, 11.2015, S. 77-82 .Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Danger signals in stroke
AU - Gelderblom, Mathias
AU - Sobey, Christopher G
AU - Kleinschnitz, Christoph
AU - Magnus, Tim
N1 - Copyright © 2015 Elsevier B.V. All rights reserved.
PY - 2015/11
Y1 - 2015/11
N2 - Danger molecules are the first signals released from dying tissue after stroke. These danger signals bind to receptors on immune cells that will result in their activation and the release of inflammatory and neurotoxic mediators, resulting in amplification of the immune response and subsequent enlargement of the damaged brain volume. The release of danger signals is a central event that leads to a multitude of signals and cascades in the affected and neighbouring tissue, therefore providing a potential target for therapy.
AB - Danger molecules are the first signals released from dying tissue after stroke. These danger signals bind to receptors on immune cells that will result in their activation and the release of inflammatory and neurotoxic mediators, resulting in amplification of the immune response and subsequent enlargement of the damaged brain volume. The release of danger signals is a central event that leads to a multitude of signals and cascades in the affected and neighbouring tissue, therefore providing a potential target for therapy.
U2 - 10.1016/j.arr.2015.07.004
DO - 10.1016/j.arr.2015.07.004
M3 - SCORING: Journal article
C2 - 26210897
VL - 24
SP - 77
EP - 82
JO - AGEING RES REV
JF - AGEING RES REV
SN - 1568-1637
IS - Pt A, Special Issue
ER -