D-amphetamine does not improve outcome of somatosensory training
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D-amphetamine does not improve outcome of somatosensory training. / Knecht, S; Imai, T; Kamping, S; Breitenstein, C; Henningsen, H; Lütkenhöner, B; Ringelstein, E B.
in: NEUROLOGY, Jahrgang 57, Nr. 12, 26.12.2001, S. 2248-52.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - D-amphetamine does not improve outcome of somatosensory training
AU - Knecht, S
AU - Imai, T
AU - Kamping, S
AU - Breitenstein, C
AU - Henningsen, H
AU - Lütkenhöner, B
AU - Ringelstein, E B
PY - 2001/12/26
Y1 - 2001/12/26
N2 - BACKGROUND: D-amphetamine has been shown to affect early stages of stroke recovery, and may have a beneficial effect on functions when administered later after stroke.OBJECTIVE: To test D-amphetamine effects on skill acquisition after the acute or subacute stages of stroke, when lesion-related structural changes have consolidated.METHODS: Sixteen healthy subjects were treated with D-amphetamine during a 4-week training of tactile frequency discrimination in a placebo-controlled, double-blind design.RESULTS: All subjects improved significantly in tactile temporal acuity. However, improvement did not differ in subjects treated with or without D-amphetamine.CONCLUSION: No beneficial effect of D-amphetamine on somatosensory training improvements was found in healthy subjects.
AB - BACKGROUND: D-amphetamine has been shown to affect early stages of stroke recovery, and may have a beneficial effect on functions when administered later after stroke.OBJECTIVE: To test D-amphetamine effects on skill acquisition after the acute or subacute stages of stroke, when lesion-related structural changes have consolidated.METHODS: Sixteen healthy subjects were treated with D-amphetamine during a 4-week training of tactile frequency discrimination in a placebo-controlled, double-blind design.RESULTS: All subjects improved significantly in tactile temporal acuity. However, improvement did not differ in subjects treated with or without D-amphetamine.CONCLUSION: No beneficial effect of D-amphetamine on somatosensory training improvements was found in healthy subjects.
KW - Adult
KW - Analysis of Variance
KW - Dextroamphetamine
KW - Discrimination Learning
KW - Double-Blind Method
KW - Drug Administration Schedule
KW - Humans
KW - Male
KW - Physical Stimulation
KW - Stroke
M3 - SCORING: Journal article
C2 - 11756605
VL - 57
SP - 2248
EP - 2252
JO - NEUROLOGY
JF - NEUROLOGY
SN - 0028-3878
IS - 12
ER -