Cytokine and Chemokine Signature in Elite versus Viremic Controllers infected with HIV
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Cytokine and Chemokine Signature in Elite versus Viremic Controllers infected with HIV. / Platten, Martin; Jung, Norma; Trapp, Susanna; Floßdorf, Pia; Meyer-Olson, Dirk; Schulze Zur Wiesch, Julian; Stephan, Christoph; Mauss, Stefan; Weiß, Verena; von Bergwelt-Balidon, Michael; Rockstroh, Juergen K; Fätkenheuer, Gerd; Lehmann, Clara.
in: AIDS RES HUM RETROV, Jahrgang 32, Nr. 6, 24.05.2016, S. 579-87.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cytokine and Chemokine Signature in Elite versus Viremic Controllers infected with HIV
AU - Platten, Martin
AU - Jung, Norma
AU - Trapp, Susanna
AU - Floßdorf, Pia
AU - Meyer-Olson, Dirk
AU - Schulze Zur Wiesch, Julian
AU - Stephan, Christoph
AU - Mauss, Stefan
AU - Weiß, Verena
AU - von Bergwelt-Balidon, Michael
AU - Rockstroh, Juergen K
AU - Fätkenheuer, Gerd
AU - Lehmann, Clara
PY - 2016/5/24
Y1 - 2016/5/24
N2 - BACKGROUND: HIV long-term non-progressors (LTNP) maintaining high CD4+ T-cell counts without antiretroviral therapy (ART)) are divided into elite controllers (EC) with undetectable and viremic controllers (VC) with low viral loads. Little is known about the long-term changes of T-cell subsets and inflammation patterns in EC versus VC. Objective To explore the long-term evolution of CD4+ T-cell levels in LTNP and to analyze cytokine profiles in EC versus VC.SUBJECTS AND METHODS: Nineteen EC and 15 VC were enrolled from the natural virus controller cohort (NaViC). T-cell counts were monitored over years, the mean annual change was calculated and plasma concentrations of 25 cytokines were evaluated using a multiplex bead array.RESULTS: While absolute numbers of T-cells did not differ between EC and VC over time, we observed a significant decrease of CD4+ T-cell percentages in VC but not in EC (median [interquartile range]: EC: 37% [28-41] vs. VC: 29% [25-34]; p=0.02). ECs had lower levels of macrophage inflammatory protein-1β (MIP-1β, p = 0.003), interferon γ-induced protein-10 (IP-10, p = 0.03) and monokine induced by interferon-γ (MIG, p = 0.02). CD4+ T-cell percentages inversely correlated with MIP 1-β (r = -0.42, p = 0.017) and IP-10 (r = -0.77, p< 0.0001) Conclusions: A subtle decline of CD4+ T-cell percentages could be observed in VC but not in EC, which was associated with higher plasma levels of proinflammatory cytokines. Hence, even low levels of HIV replication might go along with a progressive decline in CD4+ T-cell counts in LTNP.
AB - BACKGROUND: HIV long-term non-progressors (LTNP) maintaining high CD4+ T-cell counts without antiretroviral therapy (ART)) are divided into elite controllers (EC) with undetectable and viremic controllers (VC) with low viral loads. Little is known about the long-term changes of T-cell subsets and inflammation patterns in EC versus VC. Objective To explore the long-term evolution of CD4+ T-cell levels in LTNP and to analyze cytokine profiles in EC versus VC.SUBJECTS AND METHODS: Nineteen EC and 15 VC were enrolled from the natural virus controller cohort (NaViC). T-cell counts were monitored over years, the mean annual change was calculated and plasma concentrations of 25 cytokines were evaluated using a multiplex bead array.RESULTS: While absolute numbers of T-cells did not differ between EC and VC over time, we observed a significant decrease of CD4+ T-cell percentages in VC but not in EC (median [interquartile range]: EC: 37% [28-41] vs. VC: 29% [25-34]; p=0.02). ECs had lower levels of macrophage inflammatory protein-1β (MIP-1β, p = 0.003), interferon γ-induced protein-10 (IP-10, p = 0.03) and monokine induced by interferon-γ (MIG, p = 0.02). CD4+ T-cell percentages inversely correlated with MIP 1-β (r = -0.42, p = 0.017) and IP-10 (r = -0.77, p< 0.0001) Conclusions: A subtle decline of CD4+ T-cell percentages could be observed in VC but not in EC, which was associated with higher plasma levels of proinflammatory cytokines. Hence, even low levels of HIV replication might go along with a progressive decline in CD4+ T-cell counts in LTNP.
U2 - 10.1089/AID.2015.0226
DO - 10.1089/AID.2015.0226
M3 - SCORING: Journal article
C2 - 26751176
VL - 32
SP - 579
EP - 587
JO - AIDS RES HUM RETROV
JF - AIDS RES HUM RETROV
SN - 0889-2229
IS - 6
ER -