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Cytogenetics of extramedullary manifestations in multiple myeloma

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Cytogenetics of extramedullary manifestations in multiple myeloma. / Billecke, Lisa; Murga Penas, Eva M; May, Annette M; Engelhardt, Monika; Nagler, Arnon; Leiba, Merav; Schiby, Ginette; Kröger, Nicolaus; Zustin, Josef; Marx, Andreas; Matschke, Jakob; Tiemann, Markus; Goekkurt, Eray; Heidtmann, Hans-Heinrich; Vettorazzi, Eik; Dierlamm, Judith; Bokemeyer, Carsten; Schilling, Georgia.

in: BRIT J HAEMATOL, Jahrgang 161, Nr. 1, 1, 2013, S. 87-94.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Billecke, L, Murga Penas, EM, May, AM, Engelhardt, M, Nagler, A, Leiba, M, Schiby, G, Kröger, N, Zustin, J, Marx, A, Matschke, J, Tiemann, M, Goekkurt, E, Heidtmann, H-H, Vettorazzi, E, Dierlamm, J, Bokemeyer, C & Schilling, G 2013, 'Cytogenetics of extramedullary manifestations in multiple myeloma', BRIT J HAEMATOL, Jg. 161, Nr. 1, 1, S. 87-94. https://doi.org/10.1111/bjh.12223

APA

Billecke, L., Murga Penas, E. M., May, A. M., Engelhardt, M., Nagler, A., Leiba, M., Schiby, G., Kröger, N., Zustin, J., Marx, A., Matschke, J., Tiemann, M., Goekkurt, E., Heidtmann, H-H., Vettorazzi, E., Dierlamm, J., Bokemeyer, C., & Schilling, G. (2013). Cytogenetics of extramedullary manifestations in multiple myeloma. BRIT J HAEMATOL, 161(1), 87-94. [1]. https://doi.org/10.1111/bjh.12223

Vancouver

Billecke L, Murga Penas EM, May AM, Engelhardt M, Nagler A, Leiba M et al. Cytogenetics of extramedullary manifestations in multiple myeloma. BRIT J HAEMATOL. 2013;161(1):87-94. 1. https://doi.org/10.1111/bjh.12223

Bibtex

@article{4633acf7f6b346889fdd65f6702e1893,
title = "Cytogenetics of extramedullary manifestations in multiple myeloma",
abstract = "Extramedullary disease in patients with multiple myeloma is a rare event, occurring mostly in advanced disease or relapse. Outcome is poor and prognostic factors predicting the development of extramedullary disease have not been defined. We investigated cytogenetic alterations of myeloma cells in different extramedullary manifestations by adapting the fluorescence in situ hybridization (FISH) technique in combination with cytoplasmic immunoglobulin staining to study the cytogenetics of plasma cell tumours on paraffin embedded material. Thirty six patients were investigated: 19 with extramedullary disease, 11 with skeletal extramedullary disease and six with solitary extramedullary plasmacytoma. The first two groups showed the following results: del(17p13) 32% vs. 27%, del(13q14) 35% vs. 27%, MYC-overrepresentation 28% vs. 18% and t(4;14) 37% vs. 18%. We detected an overall higher incidence of del(17p13) in both groups compared to data from bone marrow samples of multiple myeloma reported to date (range 7-16%). The solitary extramedullary plasmacytomas presented overall less cytogenetic aberrations than the other groups. Most important, three patients with extramedullary disease and one with skeletal extramedullary disease presented different FISH findings in the extramedullary tumour compared to their bone marrow plasma cells. del(17p13), occurring additional in three of four cases, seems a strong marker for extramedullary progression of myeloma.",
keywords = "Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Young Adult, Retrospective Studies, Chromosome Deletion, In Situ Hybridization, Fluorescence, *Chromosome Aberrations, Chromosomes, Human, Pair 17/genetics, Multiple Myeloma/*genetics/pathology/therapy, Plasmacytoma/genetics/pathology, Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Young Adult, Retrospective Studies, Chromosome Deletion, In Situ Hybridization, Fluorescence, *Chromosome Aberrations, Chromosomes, Human, Pair 17/genetics, Multiple Myeloma/*genetics/pathology/therapy, Plasmacytoma/genetics/pathology",
author = "Lisa Billecke and {Murga Penas}, {Eva M} and May, {Annette M} and Monika Engelhardt and Arnon Nagler and Merav Leiba and Ginette Schiby and Nicolaus Kr{\"o}ger and Josef Zustin and Andreas Marx and Jakob Matschke and Markus Tiemann and Eray Goekkurt and Hans-Heinrich Heidtmann and Eik Vettorazzi and Judith Dierlamm and Carsten Bokemeyer and Georgia Schilling",
note = "{\textcopyright} 2013 Blackwell Publishing Ltd.",
year = "2013",
doi = "10.1111/bjh.12223",
language = "English",
volume = "161",
pages = "87--94",
journal = "BRIT J HAEMATOL",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Cytogenetics of extramedullary manifestations in multiple myeloma

AU - Billecke, Lisa

AU - Murga Penas, Eva M

AU - May, Annette M

AU - Engelhardt, Monika

AU - Nagler, Arnon

AU - Leiba, Merav

AU - Schiby, Ginette

AU - Kröger, Nicolaus

AU - Zustin, Josef

AU - Marx, Andreas

AU - Matschke, Jakob

AU - Tiemann, Markus

AU - Goekkurt, Eray

AU - Heidtmann, Hans-Heinrich

AU - Vettorazzi, Eik

AU - Dierlamm, Judith

AU - Bokemeyer, Carsten

AU - Schilling, Georgia

N1 - © 2013 Blackwell Publishing Ltd.

PY - 2013

Y1 - 2013

N2 - Extramedullary disease in patients with multiple myeloma is a rare event, occurring mostly in advanced disease or relapse. Outcome is poor and prognostic factors predicting the development of extramedullary disease have not been defined. We investigated cytogenetic alterations of myeloma cells in different extramedullary manifestations by adapting the fluorescence in situ hybridization (FISH) technique in combination with cytoplasmic immunoglobulin staining to study the cytogenetics of plasma cell tumours on paraffin embedded material. Thirty six patients were investigated: 19 with extramedullary disease, 11 with skeletal extramedullary disease and six with solitary extramedullary plasmacytoma. The first two groups showed the following results: del(17p13) 32% vs. 27%, del(13q14) 35% vs. 27%, MYC-overrepresentation 28% vs. 18% and t(4;14) 37% vs. 18%. We detected an overall higher incidence of del(17p13) in both groups compared to data from bone marrow samples of multiple myeloma reported to date (range 7-16%). The solitary extramedullary plasmacytomas presented overall less cytogenetic aberrations than the other groups. Most important, three patients with extramedullary disease and one with skeletal extramedullary disease presented different FISH findings in the extramedullary tumour compared to their bone marrow plasma cells. del(17p13), occurring additional in three of four cases, seems a strong marker for extramedullary progression of myeloma.

AB - Extramedullary disease in patients with multiple myeloma is a rare event, occurring mostly in advanced disease or relapse. Outcome is poor and prognostic factors predicting the development of extramedullary disease have not been defined. We investigated cytogenetic alterations of myeloma cells in different extramedullary manifestations by adapting the fluorescence in situ hybridization (FISH) technique in combination with cytoplasmic immunoglobulin staining to study the cytogenetics of plasma cell tumours on paraffin embedded material. Thirty six patients were investigated: 19 with extramedullary disease, 11 with skeletal extramedullary disease and six with solitary extramedullary plasmacytoma. The first two groups showed the following results: del(17p13) 32% vs. 27%, del(13q14) 35% vs. 27%, MYC-overrepresentation 28% vs. 18% and t(4;14) 37% vs. 18%. We detected an overall higher incidence of del(17p13) in both groups compared to data from bone marrow samples of multiple myeloma reported to date (range 7-16%). The solitary extramedullary plasmacytomas presented overall less cytogenetic aberrations than the other groups. Most important, three patients with extramedullary disease and one with skeletal extramedullary disease presented different FISH findings in the extramedullary tumour compared to their bone marrow plasma cells. del(17p13), occurring additional in three of four cases, seems a strong marker for extramedullary progression of myeloma.

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Young Adult

KW - Retrospective Studies

KW - Chromosome Deletion

KW - In Situ Hybridization, Fluorescence

KW - Chromosome Aberrations

KW - Chromosomes, Human, Pair 17/genetics

KW - Multiple Myeloma/genetics/pathology/therapy

KW - Plasmacytoma/genetics/pathology

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Young Adult

KW - Retrospective Studies

KW - Chromosome Deletion

KW - In Situ Hybridization, Fluorescence

KW - Chromosome Aberrations

KW - Chromosomes, Human, Pair 17/genetics

KW - Multiple Myeloma/genetics/pathology/therapy

KW - Plasmacytoma/genetics/pathology

U2 - 10.1111/bjh.12223

DO - 10.1111/bjh.12223

M3 - SCORING: Journal article

C2 - 23368088

VL - 161

SP - 87

EP - 94

JO - BRIT J HAEMATOL

JF - BRIT J HAEMATOL

SN - 0007-1048

IS - 1

M1 - 1

ER -