Cystic fibrosis transmembrane conductance regulator can export hyaluronan.
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Cystic fibrosis transmembrane conductance regulator can export hyaluronan. / Schulz, Tobias; Schumacher, Udo; Prante, Christian; Sextro, Wolfgang; Prehm, Peter.
in: PATHOBIOLOGY, Jahrgang 77, Nr. 4, 4, 2010, S. 200-209.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cystic fibrosis transmembrane conductance regulator can export hyaluronan.
AU - Schulz, Tobias
AU - Schumacher, Udo
AU - Prante, Christian
AU - Sextro, Wolfgang
AU - Prehm, Peter
PY - 2010
Y1 - 2010
N2 - Hyaluronan, a major water binding component of the extracellular matrix, is synthesised within the cytosol and exported across the plasma membrane by the ABC-transporter MRP5 in fibroblasts. Although its synthesis is vital for embryogenesis, MRP5-deficient mice are without phenotype, suggesting that another transporter had substituted for the MRP5 protein. Thus, we searched for a compensatory exporter in fibroblasts from MRP5 deficient mice and found that cystic fibrosis transmembrane conductance regulator (CFTR) mRNA was upregulated.
AB - Hyaluronan, a major water binding component of the extracellular matrix, is synthesised within the cytosol and exported across the plasma membrane by the ABC-transporter MRP5 in fibroblasts. Although its synthesis is vital for embryogenesis, MRP5-deficient mice are without phenotype, suggesting that another transporter had substituted for the MRP5 protein. Thus, we searched for a compensatory exporter in fibroblasts from MRP5 deficient mice and found that cystic fibrosis transmembrane conductance regulator (CFTR) mRNA was upregulated.
M3 - SCORING: Zeitschriftenaufsatz
VL - 77
SP - 200
EP - 209
JO - PATHOBIOLOGY
JF - PATHOBIOLOGY
SN - 1015-2008
IS - 4
M1 - 4
ER -
