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Cyclosporine area under the curve after allogeneic hematopoietic stem cell transplantation is an indicator of Epstein-Barr virus DNAemia

Standard

Cyclosporine area under the curve after allogeneic hematopoietic stem cell transplantation is an indicator of Epstein-Barr virus DNAemia. / Christopeit, Maximilian; Janssen, Nils; Weber, Thomas; Bacher, Ulrike; Lautenschläger, Christine; Oehme, Albrecht; Kekulé, Alexander S; Schmoll, Hans-Joachim.

in: LEUKEMIA LYMPHOMA, Jahrgang 54, Nr. 1, 01.2013, S. 133-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Christopeit, M, Janssen, N, Weber, T, Bacher, U, Lautenschläger, C, Oehme, A, Kekulé, AS & Schmoll, H-J 2013, 'Cyclosporine area under the curve after allogeneic hematopoietic stem cell transplantation is an indicator of Epstein-Barr virus DNAemia', LEUKEMIA LYMPHOMA, Jg. 54, Nr. 1, S. 133-7. https://doi.org/10.3109/10428194.2012.705001

APA

Christopeit, M., Janssen, N., Weber, T., Bacher, U., Lautenschläger, C., Oehme, A., Kekulé, A. S., & Schmoll, H-J. (2013). Cyclosporine area under the curve after allogeneic hematopoietic stem cell transplantation is an indicator of Epstein-Barr virus DNAemia. LEUKEMIA LYMPHOMA, 54(1), 133-7. https://doi.org/10.3109/10428194.2012.705001

Vancouver

Christopeit M, Janssen N, Weber T, Bacher U, Lautenschläger C, Oehme A et al. Cyclosporine area under the curve after allogeneic hematopoietic stem cell transplantation is an indicator of Epstein-Barr virus DNAemia. LEUKEMIA LYMPHOMA. 2013 Jan;54(1):133-7. https://doi.org/10.3109/10428194.2012.705001

Bibtex

@article{c3c56ce456f9440cb568ec07e2eb5b83,
title = "Cyclosporine area under the curve after allogeneic hematopoietic stem cell transplantation is an indicator of Epstein-Barr virus DNAemia",
abstract = "Epstein-Barr virus (EBV) DNAemia and reactivation is a typical complication after allogeneic hematopoietic stem cell transplantation (HSCT). The degree of immunosuppression is closely linked to the risk of developing EBV DNAemia. An association of cyclosporine levels with EBV DNAemia has not been interrogated. Here, we analyzed cyclosporine levels in 58 patients after allogeneic HSCT. We discovered a wide range of cyclosporine trough level variation in the individual patient (median coefficient of variation [CV] 0.29, range 0.19-0.78). To overcome this high intra-individual variation in serum trough levels of cyclosporine, we calculated respective areas under the curve (AUC) and performed correlations with EBV DNAemia in 28 stem cell recipients at increased risk for EBV DNAemia. This resulted in a significant association of high cyclosporine AUC (> 6000 ng/mL × days) with EBV DNAemia after day 30 (relative risk [RR] 6.067, 95% confidence interval [CI] 1.107-33.238, p = 0.038). Conversely, mean cyclosporine values (threshold 200 ng/mL) between days 0 and 30 were not found to correlate with EBV DNAemia after day 30. Furthermore, CD3 + CD8 + graft content was inversely correlated with EBV DNAemia after day 30. These findings might establish a clinical role for the AUC of cyclosporine.",
keywords = "Adult, Aged, Confounding Factors (Epidemiology), Cyclosporine, Epstein-Barr Virus Infections, Female, Hematopoietic Stem Cell Transplantation, Herpesvirus 4, Human, Humans, Immunosuppressive Agents, Male, Middle Aged, ROC Curve, Risk Factors, Transplantation, Homologous, Viremia, Young Adult, Journal Article",
author = "Maximilian Christopeit and Nils Janssen and Thomas Weber and Ulrike Bacher and Christine Lautenschl{\"a}ger and Albrecht Oehme and Kekul{\'e}, {Alexander S} and Hans-Joachim Schmoll",
year = "2013",
month = jan,
doi = "10.3109/10428194.2012.705001",
language = "English",
volume = "54",
pages = "133--7",
journal = "LEUKEMIA LYMPHOMA",
issn = "1042-8194",
publisher = "informa healthcare",
number = "1",

}

RIS

TY - JOUR

T1 - Cyclosporine area under the curve after allogeneic hematopoietic stem cell transplantation is an indicator of Epstein-Barr virus DNAemia

AU - Christopeit, Maximilian

AU - Janssen, Nils

AU - Weber, Thomas

AU - Bacher, Ulrike

AU - Lautenschläger, Christine

AU - Oehme, Albrecht

AU - Kekulé, Alexander S

AU - Schmoll, Hans-Joachim

PY - 2013/1

Y1 - 2013/1

N2 - Epstein-Barr virus (EBV) DNAemia and reactivation is a typical complication after allogeneic hematopoietic stem cell transplantation (HSCT). The degree of immunosuppression is closely linked to the risk of developing EBV DNAemia. An association of cyclosporine levels with EBV DNAemia has not been interrogated. Here, we analyzed cyclosporine levels in 58 patients after allogeneic HSCT. We discovered a wide range of cyclosporine trough level variation in the individual patient (median coefficient of variation [CV] 0.29, range 0.19-0.78). To overcome this high intra-individual variation in serum trough levels of cyclosporine, we calculated respective areas under the curve (AUC) and performed correlations with EBV DNAemia in 28 stem cell recipients at increased risk for EBV DNAemia. This resulted in a significant association of high cyclosporine AUC (> 6000 ng/mL × days) with EBV DNAemia after day 30 (relative risk [RR] 6.067, 95% confidence interval [CI] 1.107-33.238, p = 0.038). Conversely, mean cyclosporine values (threshold 200 ng/mL) between days 0 and 30 were not found to correlate with EBV DNAemia after day 30. Furthermore, CD3 + CD8 + graft content was inversely correlated with EBV DNAemia after day 30. These findings might establish a clinical role for the AUC of cyclosporine.

AB - Epstein-Barr virus (EBV) DNAemia and reactivation is a typical complication after allogeneic hematopoietic stem cell transplantation (HSCT). The degree of immunosuppression is closely linked to the risk of developing EBV DNAemia. An association of cyclosporine levels with EBV DNAemia has not been interrogated. Here, we analyzed cyclosporine levels in 58 patients after allogeneic HSCT. We discovered a wide range of cyclosporine trough level variation in the individual patient (median coefficient of variation [CV] 0.29, range 0.19-0.78). To overcome this high intra-individual variation in serum trough levels of cyclosporine, we calculated respective areas under the curve (AUC) and performed correlations with EBV DNAemia in 28 stem cell recipients at increased risk for EBV DNAemia. This resulted in a significant association of high cyclosporine AUC (> 6000 ng/mL × days) with EBV DNAemia after day 30 (relative risk [RR] 6.067, 95% confidence interval [CI] 1.107-33.238, p = 0.038). Conversely, mean cyclosporine values (threshold 200 ng/mL) between days 0 and 30 were not found to correlate with EBV DNAemia after day 30. Furthermore, CD3 + CD8 + graft content was inversely correlated with EBV DNAemia after day 30. These findings might establish a clinical role for the AUC of cyclosporine.

KW - Adult

KW - Aged

KW - Confounding Factors (Epidemiology)

KW - Cyclosporine

KW - Epstein-Barr Virus Infections

KW - Female

KW - Hematopoietic Stem Cell Transplantation

KW - Herpesvirus 4, Human

KW - Humans

KW - Immunosuppressive Agents

KW - Male

KW - Middle Aged

KW - ROC Curve

KW - Risk Factors

KW - Transplantation, Homologous

KW - Viremia

KW - Young Adult

KW - Journal Article

U2 - 10.3109/10428194.2012.705001

DO - 10.3109/10428194.2012.705001

M3 - SCORING: Journal article

C2 - 22721496

VL - 54

SP - 133

EP - 137

JO - LEUKEMIA LYMPHOMA

JF - LEUKEMIA LYMPHOMA

SN - 1042-8194

IS - 1

ER -