CXCR4/SDF-1α-mediated chemotaxis in an in vivo model of metastatic esophageal carcinoma.
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CXCR4/SDF-1α-mediated chemotaxis in an in vivo model of metastatic esophageal carcinoma. / Gros, Stephanie; Graeff, Hanna; Drenckhan, Astrid; Kurschat, Nina; Blessmann, Marco; Rawnaq, Tamina; Izbicki, Jakob R.
in: IN VIVO, Jahrgang 26, Nr. 4, 4, 2012, S. 711-718.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - CXCR4/SDF-1α-mediated chemotaxis in an in vivo model of metastatic esophageal carcinoma.
AU - Gros, Stephanie
AU - Graeff, Hanna
AU - Drenckhan, Astrid
AU - Kurschat, Nina
AU - Blessmann, Marco
AU - Rawnaq, Tamina
AU - Izbicki, Jakob R.
PY - 2012
Y1 - 2012
N2 - The chemokine receptor CXCR4 and its ligand (stromal cell-derived factor-1alpha; SDF-1?) play an important role in tumor cell chemotaxis and metastatic homing of esophageal carcinoma. Several methods are available to examine tumor cell migration in vitro. However, in vivo chemotaxis is subject to complex tumor-host interactions. The aim of this study was to establish an in vivo model of chemotaxis for esophageal carcinoma that allows the examination of tumor cell migration and metastatic homing in the complex microenvironment.
AB - The chemokine receptor CXCR4 and its ligand (stromal cell-derived factor-1alpha; SDF-1?) play an important role in tumor cell chemotaxis and metastatic homing of esophageal carcinoma. Several methods are available to examine tumor cell migration in vitro. However, in vivo chemotaxis is subject to complex tumor-host interactions. The aim of this study was to establish an in vivo model of chemotaxis for esophageal carcinoma that allows the examination of tumor cell migration and metastatic homing in the complex microenvironment.
KW - Animals
KW - Mice
KW - Neoplasm Metastasis
KW - Chemokine CXCL12/physiology
KW - Chemotaxis/physiology
KW - Esophageal Neoplasms/pathology
KW - Receptors, CXCR4/physiology
KW - Animals
KW - Mice
KW - Neoplasm Metastasis
KW - Chemokine CXCL12/physiology
KW - Chemotaxis/physiology
KW - Esophageal Neoplasms/pathology
KW - Receptors, CXCR4/physiology
M3 - SCORING: Journal article
VL - 26
SP - 711
EP - 718
JO - IN VIVO
JF - IN VIVO
SN - 0258-851X
IS - 4
M1 - 4
ER -