Cutaneous presentation of hematological malignancies
Standard
Cutaneous presentation of hematological malignancies. / Eberle, Franziska C; Metzler, Gisela; Weisel, Katja C; Berneburg, Mark; Yazdi, Amir S.
in: EUR J DERMATOL, Jahrgang 23, Nr. 3, 21.06.2013, S. 372-7.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Cutaneous presentation of hematological malignancies
AU - Eberle, Franziska C
AU - Metzler, Gisela
AU - Weisel, Katja C
AU - Berneburg, Mark
AU - Yazdi, Amir S
PY - 2013/6/21
Y1 - 2013/6/21
N2 - Systemic hematological malignancies can present in the skin as specific secondary cutaneous lymphoma or as non-specific skin manifestations. In the majority of cases, patients are first diagnosed with a systemic lymphoma and may subsequently develop skin involvement. Rarely, the cutaneous symptoms precede the diagnosis of systemic hematological disorders. In these patients, cutaneous infiltrates can present a challenge to both the clinician and the pathologist. We report a series of five patients with clinically and histologically heterogeneous characteristics, in which careful diagnostic procedures finally led to the diagnosis of systemic hematological malignancies. Interdisciplinary clinical and laboratory examination, including histological and molecular analysis and imaging rendered possible the diagnosis of the underlying hematological malignancy. The here-described approaches allowed the diagnosis and therapy of so-far unrecognized hematological malignancies in patients initially presenting exclusively with cutaneous symptoms.
AB - Systemic hematological malignancies can present in the skin as specific secondary cutaneous lymphoma or as non-specific skin manifestations. In the majority of cases, patients are first diagnosed with a systemic lymphoma and may subsequently develop skin involvement. Rarely, the cutaneous symptoms precede the diagnosis of systemic hematological disorders. In these patients, cutaneous infiltrates can present a challenge to both the clinician and the pathologist. We report a series of five patients with clinically and histologically heterogeneous characteristics, in which careful diagnostic procedures finally led to the diagnosis of systemic hematological malignancies. Interdisciplinary clinical and laboratory examination, including histological and molecular analysis and imaging rendered possible the diagnosis of the underlying hematological malignancy. The here-described approaches allowed the diagnosis and therapy of so-far unrecognized hematological malignancies in patients initially presenting exclusively with cutaneous symptoms.
KW - Aged
KW - Female
KW - Hematologic Neoplasms
KW - Humans
KW - Male
KW - Middle Aged
KW - Skin Neoplasms
KW - Case Reports
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1684/ejd.2013.2010
DO - 10.1684/ejd.2013.2010
M3 - SCORING: Journal article
C2 - 23782893
VL - 23
SP - 372
EP - 377
JO - EUR J DERMATOL
JF - EUR J DERMATOL
SN - 1167-1122
IS - 3
ER -