Current treatment of heart failure with preserved ejection fraction: should we add life to the remaining years or add years to the remaining life?
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Current treatment of heart failure with preserved ejection fraction: should we add life to the remaining years or add years to the remaining life? / Li, Jia; Becher, Peter Moritz; Blankenberg, Stefan; Westermann, Dirk.
in: CARDIOL RES PRACT, Jahrgang 2013, 2013, S. 130724.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Current treatment of heart failure with preserved ejection fraction: should we add life to the remaining years or add years to the remaining life?
AU - Li, Jia
AU - Becher, Peter Moritz
AU - Blankenberg, Stefan
AU - Westermann, Dirk
PY - 2013
Y1 - 2013
N2 - ACCORDING TO THE EJECTION FRACTION, PATIENTS WITH HEART FAILURE MAY BE DIVIDED INTO TWO DIFFERENT GROUPS: heart failure with preserved or reduced ejection fraction. In recent years, accumulating studies showed that increased mortality and morbidity rates of these two groups are nearly equal. More importantly, despite decline in mortality after treatment in regard to current guideline in patients with heart failure with reduced ejection fraction, there are still no trials resulting in improved outcome in patients with heart failure with preserved ejection fraction so far. Thus, novel pathophysiological mechanisms are under development, and other new viewpoints, such as multiple comorbidities resulting in increased non-cardiac deaths in patients with heart failure and preserved ejection fraction, were presented recently. In this review, we will focus on the tested as well as the promising therapeutic options that are currently studied in patients with heart failure with preserved ejection fraction, along with a brief discussion of pathophysiological mechanisms and diagnostic options that are helpful to increase our understanding of novel therapeutic strategies.
AB - ACCORDING TO THE EJECTION FRACTION, PATIENTS WITH HEART FAILURE MAY BE DIVIDED INTO TWO DIFFERENT GROUPS: heart failure with preserved or reduced ejection fraction. In recent years, accumulating studies showed that increased mortality and morbidity rates of these two groups are nearly equal. More importantly, despite decline in mortality after treatment in regard to current guideline in patients with heart failure with reduced ejection fraction, there are still no trials resulting in improved outcome in patients with heart failure with preserved ejection fraction so far. Thus, novel pathophysiological mechanisms are under development, and other new viewpoints, such as multiple comorbidities resulting in increased non-cardiac deaths in patients with heart failure and preserved ejection fraction, were presented recently. In this review, we will focus on the tested as well as the promising therapeutic options that are currently studied in patients with heart failure with preserved ejection fraction, along with a brief discussion of pathophysiological mechanisms and diagnostic options that are helpful to increase our understanding of novel therapeutic strategies.
U2 - 10.1155/2013/130724
DO - 10.1155/2013/130724
M3 - SCORING: Review article
C2 - 24251065
VL - 2013
SP - 130724
JO - CARDIOL RES PRACT
JF - CARDIOL RES PRACT
SN - 2090-8016
ER -