Current resultson PSA-based prostate cancer detection
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Current resultson PSA-based prostate cancer detection. / Graefen, M; Schlomm, T; Steuber, T; Sauter, G.
in: BUNDESGESUNDHEITSBLA, Jahrgang 57, Nr. 3, 01.03.2014, S. 312-7.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Current resultson PSA-based prostate cancer detection
AU - Graefen, M
AU - Schlomm, T
AU - Steuber, T
AU - Sauter, G
PY - 2014/3/1
Y1 - 2014/3/1
N2 - Prostate cancer is the most common cancer and the third leading cause of cancer-specific death in men in Western industrialized countries. Implementation of the prostate-specific antigen (PSA) blood test as an early detection tool has led to a significant reduction of prostate cancer mortality in the USA. Apart from an earlier detection of clinically relevant tumors, regular PSA testing increases the risk of over-detection and over-treatment of clinically indolent tumors. In our view, a reliable stratification of indolent tumors in active surveillance programs is the key in avoiding or reducing overtreatment of early diagnosed prostate cancers. Along with better risk stratification, the expansion of PSA screening should be discussed in order to reduce the still high numbers of palliative treatments, metastases, and prostate cancer-related deaths.
AB - Prostate cancer is the most common cancer and the third leading cause of cancer-specific death in men in Western industrialized countries. Implementation of the prostate-specific antigen (PSA) blood test as an early detection tool has led to a significant reduction of prostate cancer mortality in the USA. Apart from an earlier detection of clinically relevant tumors, regular PSA testing increases the risk of over-detection and over-treatment of clinically indolent tumors. In our view, a reliable stratification of indolent tumors in active surveillance programs is the key in avoiding or reducing overtreatment of early diagnosed prostate cancers. Along with better risk stratification, the expansion of PSA screening should be discussed in order to reduce the still high numbers of palliative treatments, metastases, and prostate cancer-related deaths.
KW - Diagnostic Errors
KW - Early Detection of Cancer
KW - Evidence-Based Medicine
KW - Humans
KW - Male
KW - Prevalence
KW - Prostate-Specific Antigen
KW - Prostatic Neoplasms
KW - Reproducibility of Results
KW - Risk Assessment
KW - Sensitivity and Specificity
KW - Tumor Markers, Biological
U2 - 10.1007/s00103-013-1905-0
DO - 10.1007/s00103-013-1905-0
M3 - SCORING: Zeitschriftenaufsatz
C2 - 24562706
VL - 57
SP - 312
EP - 317
JO - BUNDESGESUNDHEITSBLA
JF - BUNDESGESUNDHEITSBLA
SN - 1436-9990
IS - 3
ER -