Current and cumulative night shift work and subclinical atherosclerosis: results of the Gutenberg Health Study
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Current and cumulative night shift work and subclinical atherosclerosis: results of the Gutenberg Health Study. / Jankowiak, S; Backé, E; Liebers, F; Schulz, A; Hegewald, J; Garthus-Niegel, S; Nübling, M; Blankenberg, S; Pfeiffer, N; Lackner, K J; Beutel, M; Blettner, M; Münzel, T; Wild, P S; Seidler, A; Letzel, S; Latza, U.
in: INT ARCH OCC ENV HEA, Jahrgang 89, Nr. 8, 11.2016, S. 1169-1182.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Current and cumulative night shift work and subclinical atherosclerosis: results of the Gutenberg Health Study
AU - Jankowiak, S
AU - Backé, E
AU - Liebers, F
AU - Schulz, A
AU - Hegewald, J
AU - Garthus-Niegel, S
AU - Nübling, M
AU - Blankenberg, S
AU - Pfeiffer, N
AU - Lackner, K J
AU - Beutel, M
AU - Blettner, M
AU - Münzel, T
AU - Wild, P S
AU - Seidler, A
AU - Letzel, S
AU - Latza, U
PY - 2016/11
Y1 - 2016/11
N2 - PURPOSE: The study examines the association between exposure to current and cumulative night shift work and subclinical parameters of atherosclerosis.METHODS: Participants of a population-based cohort study (the Gutenberg Health Study, N = 15,010) aged 35-64 years were examined at baseline (2007-2012). Investigations included measurements of arterial stiffness, vascular function [reactive hyperaemia (RH) index], and intima media thickness (IMT). Also, a complete job history (including up to 15 periods), occupational exposures, a variety of lifestyle, and dispositional variables were enquired.RESULTS: Night shift work was performed by 1071 out of 8065 currently employed individuals. The strongest association after adjustment for age, sex, job complexity level, being a manager, overtime work, and noise appeared for more than 660 night shifts within the last 10 years and a significantly increased arterial stiffness of 0.33 m/s. This reflects a 4 % flow velocity increase for individuals with more than 660 night shifts compared to non-night workers. Regarding the entire professional life, night shift workers showed a significantly decreased vascular function by -0.054 RH index points by using the same adjustment. IMT values did not differ statistically from non-night workers. Lifestyle and dispositional factors showed an influence on all used subclinical atherosclerosis parameters.CONCLUSIONS: The cross-sectional results demonstrate an association between night work and detrimental changes in the atherosclerotic process. The association is more pronounced with more years in night shift and is partly explained by lifestyle and dispositional factors. Longitudinal analyses are necessary to confirm the results.
AB - PURPOSE: The study examines the association between exposure to current and cumulative night shift work and subclinical parameters of atherosclerosis.METHODS: Participants of a population-based cohort study (the Gutenberg Health Study, N = 15,010) aged 35-64 years were examined at baseline (2007-2012). Investigations included measurements of arterial stiffness, vascular function [reactive hyperaemia (RH) index], and intima media thickness (IMT). Also, a complete job history (including up to 15 periods), occupational exposures, a variety of lifestyle, and dispositional variables were enquired.RESULTS: Night shift work was performed by 1071 out of 8065 currently employed individuals. The strongest association after adjustment for age, sex, job complexity level, being a manager, overtime work, and noise appeared for more than 660 night shifts within the last 10 years and a significantly increased arterial stiffness of 0.33 m/s. This reflects a 4 % flow velocity increase for individuals with more than 660 night shifts compared to non-night workers. Regarding the entire professional life, night shift workers showed a significantly decreased vascular function by -0.054 RH index points by using the same adjustment. IMT values did not differ statistically from non-night workers. Lifestyle and dispositional factors showed an influence on all used subclinical atherosclerosis parameters.CONCLUSIONS: The cross-sectional results demonstrate an association between night work and detrimental changes in the atherosclerotic process. The association is more pronounced with more years in night shift and is partly explained by lifestyle and dispositional factors. Longitudinal analyses are necessary to confirm the results.
KW - Adult
KW - Atherosclerosis/epidemiology
KW - Carotid Intima-Media Thickness
KW - Cohort Studies
KW - Cross-Sectional Studies
KW - Female
KW - Health Surveys
KW - Humans
KW - Hyperemia
KW - Life Style
KW - Male
KW - Middle Aged
KW - Occupational Diseases/epidemiology
KW - Occupational Exposure/adverse effects
KW - Risk Factors
KW - Time Factors
KW - Vascular Stiffness
KW - Work Schedule Tolerance/physiology
U2 - 10.1007/s00420-016-1150-6
DO - 10.1007/s00420-016-1150-6
M3 - SCORING: Journal article
C2 - 27379667
VL - 89
SP - 1169
EP - 1182
JO - INT ARCH OCC ENV HEA
JF - INT ARCH OCC ENV HEA
SN - 0340-0131
IS - 8
ER -
