Cue-induced craving increases impulsivity via changes in striatal value signals in problem gamblers
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Cue-induced craving increases impulsivity via changes in striatal value signals in problem gamblers. / Miedl, Stephan F; Büchel, Christian; Peters, Jan.
in: J NEUROSCI, Jahrgang 34, Nr. 13, 2014, S. 4750-5.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cue-induced craving increases impulsivity via changes in striatal value signals in problem gamblers
AU - Miedl, Stephan F
AU - Büchel, Christian
AU - Peters, Jan
PY - 2014
Y1 - 2014
N2 - Impulsive behavior such as steep temporal discounting is a hallmark of addiction and is associated with relapse. In pathological gamblers, discounting may be further increased by the presence of gambling-related cues in the environment, but the extent to which the gambling relatedness of task settings affects reward responses in gambling addiction is debated. In the present study, human problem gamblers made choices between immediate rewards and individually tailored larger-but-later rewards while visual gambling-related scenes were presented in the background. N = 17 participants were scanned using fMRI, whereas N = 5 additional participants completed a behavioral version of the task. Postscan craving ratings were acquired for each image, and behavioral and neuroimaging data were analyzed separately for high- and low-craving trials (median split analysis). Discounting was steeper for high versus low craving trials. Neuroimaging revealed a positive correlation with model-based subjective value in midbrain and striatum in low-craving trials that was reversed in high-craving trials. These findings reveal a modulation of striatal reward responses in gamblers by addiction-related cues, and highlight a potentially important mechanism that may contribute to relapse. Cue-induced changes in striatal delayed reward signals may lead to increased discounting of future rewards, which might in turn affect the likelihood of relapse.
AB - Impulsive behavior such as steep temporal discounting is a hallmark of addiction and is associated with relapse. In pathological gamblers, discounting may be further increased by the presence of gambling-related cues in the environment, but the extent to which the gambling relatedness of task settings affects reward responses in gambling addiction is debated. In the present study, human problem gamblers made choices between immediate rewards and individually tailored larger-but-later rewards while visual gambling-related scenes were presented in the background. N = 17 participants were scanned using fMRI, whereas N = 5 additional participants completed a behavioral version of the task. Postscan craving ratings were acquired for each image, and behavioral and neuroimaging data were analyzed separately for high- and low-craving trials (median split analysis). Discounting was steeper for high versus low craving trials. Neuroimaging revealed a positive correlation with model-based subjective value in midbrain and striatum in low-craving trials that was reversed in high-craving trials. These findings reveal a modulation of striatal reward responses in gamblers by addiction-related cues, and highlight a potentially important mechanism that may contribute to relapse. Cue-induced changes in striatal delayed reward signals may lead to increased discounting of future rewards, which might in turn affect the likelihood of relapse.
KW - Adult
KW - Behavior, Addictive
KW - Computer Simulation
KW - Corpus Striatum
KW - Cues
KW - Gambling
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Impulsive Behavior
KW - Magnetic Resonance Imaging
KW - Male
KW - Oxygen
KW - Photic Stimulation
KW - Reward
U2 - 10.1523/JNEUROSCI.5020-13.2014
DO - 10.1523/JNEUROSCI.5020-13.2014
M3 - SCORING: Journal article
C2 - 24672019
VL - 34
SP - 4750
EP - 4755
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 13
ER -
