CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease.
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CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease. / Sanchez-Juan, P; Green, A; Ladogana, A; Cuadrado-Corrales, N; Sáanchez-Valle, R; Mitrováa, E; Stoeck, Katharina; Sklaviadis, T; Kulczycki, J; Hess, K; Bodemer, M; Slivarichová, D; Saiz, A; Calero, M; Ingrosso, L; Knight, R; Janssens, A C J W; van Duijn, C M; Zerr, I.
in: NEUROLOGY, Jahrgang 67, Nr. 4, 4, 2006, S. 637-643.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease.
AU - Sanchez-Juan, P
AU - Green, A
AU - Ladogana, A
AU - Cuadrado-Corrales, N
AU - Sáanchez-Valle, R
AU - Mitrováa, E
AU - Stoeck, Katharina
AU - Sklaviadis, T
AU - Kulczycki, J
AU - Hess, K
AU - Bodemer, M
AU - Slivarichová, D
AU - Saiz, A
AU - Calero, M
AU - Ingrosso, L
AU - Knight, R
AU - Janssens, A C J W
AU - van Duijn, C M
AU - Zerr, I
PY - 2006
Y1 - 2006
N2 - OBJECTIVES: To analyze the diagnostic sensitivity and specificity of various brain-derived proteins (14-3-3, Tau, neuron specific enolase [NSE], and S100b) in the CSF of patients with Creutzfeldt-Jakob disease (CJD) and to analyze biologic factors that modify these parameters. METHODS: CSF was tested for 14-3-3, Tau, NSE, and S100b in 1,859 patients with sporadic, genetic, iatrogenic, and variant CJD, and in 1,117 controls. RESULTS: The highest sensitivity was achieved for 14-3-3 and Tau in sporadic CJD (85% and 86%), and a combined determination of 14-3-3 and Tau, S100b, or NSE increased the sensitivity to over 93%. A multivariate analysis showed that the sensitivity of all tests was highest in patients with the shortest disease duration, age at onset >40 years, and homozygosity at codon 129 of the prion protein gene. In a group of patients with repeated lumbar punctures, a second test also increased the diagnostic sensitivity. CONCLUSIONS: The detection of elevated levels of brain-derived proteins in the CSF in patients with suspected Creutzfeldt-Jakob disease is a valuable diagnostic test. A second lumbar puncture may be of value in patients with atypical clinical course in whom the first test was negative.
AB - OBJECTIVES: To analyze the diagnostic sensitivity and specificity of various brain-derived proteins (14-3-3, Tau, neuron specific enolase [NSE], and S100b) in the CSF of patients with Creutzfeldt-Jakob disease (CJD) and to analyze biologic factors that modify these parameters. METHODS: CSF was tested for 14-3-3, Tau, NSE, and S100b in 1,859 patients with sporadic, genetic, iatrogenic, and variant CJD, and in 1,117 controls. RESULTS: The highest sensitivity was achieved for 14-3-3 and Tau in sporadic CJD (85% and 86%), and a combined determination of 14-3-3 and Tau, S100b, or NSE increased the sensitivity to over 93%. A multivariate analysis showed that the sensitivity of all tests was highest in patients with the shortest disease duration, age at onset >40 years, and homozygosity at codon 129 of the prion protein gene. In a group of patients with repeated lumbar punctures, a second test also increased the diagnostic sensitivity. CONCLUSIONS: The detection of elevated levels of brain-derived proteins in the CSF in patients with suspected Creutzfeldt-Jakob disease is a valuable diagnostic test. A second lumbar puncture may be of value in patients with atypical clinical course in whom the first test was negative.
M3 - SCORING: Zeitschriftenaufsatz
VL - 67
SP - 637
EP - 643
JO - NEUROLOGY
JF - NEUROLOGY
SN - 0028-3878
IS - 4
M1 - 4
ER -
