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CRP and CD14 polymorphisms correlate with coronary plaque volume in patients with coronary artery disease--IVUS substudy of the ENCORE trials

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CRP and CD14 polymorphisms correlate with coronary plaque volume in patients with coronary artery disease--IVUS substudy of the ENCORE trials. / Hermann, Matthias; Fischer, Dieter; Hoffmann, Michael M; Gasser, Theo; Quitzau, Kurt; Meinertz, Thomas; Münzel, Thomas; Lüscher, Thomas F.

in: ATHEROSCLEROSIS, Jahrgang 220, Nr. 1, 01.2012, S. 172-176.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hermann, M, Fischer, D, Hoffmann, MM, Gasser, T, Quitzau, K, Meinertz, T, Münzel, T & Lüscher, TF 2012, 'CRP and CD14 polymorphisms correlate with coronary plaque volume in patients with coronary artery disease--IVUS substudy of the ENCORE trials', ATHEROSCLEROSIS, Jg. 220, Nr. 1, S. 172-176. https://doi.org/10.1016/j.atherosclerosis.2011.10.019

APA

Hermann, M., Fischer, D., Hoffmann, M. M., Gasser, T., Quitzau, K., Meinertz, T., Münzel, T., & Lüscher, T. F. (2012). CRP and CD14 polymorphisms correlate with coronary plaque volume in patients with coronary artery disease--IVUS substudy of the ENCORE trials. ATHEROSCLEROSIS, 220(1), 172-176. https://doi.org/10.1016/j.atherosclerosis.2011.10.019

Vancouver

Hermann M, Fischer D, Hoffmann MM, Gasser T, Quitzau K, Meinertz T et al. CRP and CD14 polymorphisms correlate with coronary plaque volume in patients with coronary artery disease--IVUS substudy of the ENCORE trials. ATHEROSCLEROSIS. 2012 Jan;220(1):172-176. https://doi.org/10.1016/j.atherosclerosis.2011.10.019

Bibtex

@article{69d0a274fb214cef9ba25e148abcdb0e,
title = "CRP and CD14 polymorphisms correlate with coronary plaque volume in patients with coronary artery disease--IVUS substudy of the ENCORE trials",
abstract = "BACKGROUND: Several proinflammatory single-nucleotide polymorphisms (SNPs) have been linked to the progression of atherosclerosis and coronary artery disease (CAD). Plaque size and its destabilization by inflammatory processes are major determinants of ischemia and acute coronary syndromes. Intravascular ultrasound (IVUS) allows for quantification of plaque size in vivo. We therefore investigated the relation of plaque size with mutations of proinflammatory genes in patients with CAD.METHODS: In 196 patients with stable CAD enrolled in the ENCORE trials coronary plaque and vessel volume was assessed by IVUS. 173 patients were successfully genotyped for polymorphisms of proinflammatory genes CD14 C(-260)T and CRP C(+1444)T using the single-nucleotide polymorphism polymerase chain reaction (SNP PCR) approach.RESULTS: Baseline characteristics were comparable for all genotype groups. Higher ratios of plaque volume/vessel volume were observed in patients with the CRP 1444TT (n=11) and CD14 260TT (n=33) genotypes (p=0.016 and p=0.026, respectively).CONCLUSION: In patients with stable coronary artery disease the CRP 1444TT and CD14 260TT variants are associated with larger coronary plaque volume independently of concomitant cardiovascular risk factors.",
keywords = "Aged, C-Reactive Protein/genetics, Chi-Square Distribution, Coronary Artery Disease/diagnostic imaging, Female, Gene Frequency, Genetic Predisposition to Disease, Heterozygote, Humans, Inflammation Mediators, Lipopolysaccharide Receptors/genetics, Male, Middle Aged, Phenotype, Plaque, Atherosclerotic/diagnostic imaging, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Randomized Controlled Trials as Topic, Retrospective Studies, Risk Assessment, Risk Factors, Ultrasonography, Interventional",
author = "Matthias Hermann and Dieter Fischer and Hoffmann, {Michael M} and Theo Gasser and Kurt Quitzau and Thomas Meinertz and Thomas M{\"u}nzel and L{\"u}scher, {Thomas F}",
note = "Copyright {\textcopyright} 2011 Elsevier Ireland Ltd. All rights reserved.",
year = "2012",
month = jan,
doi = "10.1016/j.atherosclerosis.2011.10.019",
language = "English",
volume = "220",
pages = "172--176",
journal = "ATHEROSCLEROSIS",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - CRP and CD14 polymorphisms correlate with coronary plaque volume in patients with coronary artery disease--IVUS substudy of the ENCORE trials

AU - Hermann, Matthias

AU - Fischer, Dieter

AU - Hoffmann, Michael M

AU - Gasser, Theo

AU - Quitzau, Kurt

AU - Meinertz, Thomas

AU - Münzel, Thomas

AU - Lüscher, Thomas F

N1 - Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PY - 2012/1

Y1 - 2012/1

N2 - BACKGROUND: Several proinflammatory single-nucleotide polymorphisms (SNPs) have been linked to the progression of atherosclerosis and coronary artery disease (CAD). Plaque size and its destabilization by inflammatory processes are major determinants of ischemia and acute coronary syndromes. Intravascular ultrasound (IVUS) allows for quantification of plaque size in vivo. We therefore investigated the relation of plaque size with mutations of proinflammatory genes in patients with CAD.METHODS: In 196 patients with stable CAD enrolled in the ENCORE trials coronary plaque and vessel volume was assessed by IVUS. 173 patients were successfully genotyped for polymorphisms of proinflammatory genes CD14 C(-260)T and CRP C(+1444)T using the single-nucleotide polymorphism polymerase chain reaction (SNP PCR) approach.RESULTS: Baseline characteristics were comparable for all genotype groups. Higher ratios of plaque volume/vessel volume were observed in patients with the CRP 1444TT (n=11) and CD14 260TT (n=33) genotypes (p=0.016 and p=0.026, respectively).CONCLUSION: In patients with stable coronary artery disease the CRP 1444TT and CD14 260TT variants are associated with larger coronary plaque volume independently of concomitant cardiovascular risk factors.

AB - BACKGROUND: Several proinflammatory single-nucleotide polymorphisms (SNPs) have been linked to the progression of atherosclerosis and coronary artery disease (CAD). Plaque size and its destabilization by inflammatory processes are major determinants of ischemia and acute coronary syndromes. Intravascular ultrasound (IVUS) allows for quantification of plaque size in vivo. We therefore investigated the relation of plaque size with mutations of proinflammatory genes in patients with CAD.METHODS: In 196 patients with stable CAD enrolled in the ENCORE trials coronary plaque and vessel volume was assessed by IVUS. 173 patients were successfully genotyped for polymorphisms of proinflammatory genes CD14 C(-260)T and CRP C(+1444)T using the single-nucleotide polymorphism polymerase chain reaction (SNP PCR) approach.RESULTS: Baseline characteristics were comparable for all genotype groups. Higher ratios of plaque volume/vessel volume were observed in patients with the CRP 1444TT (n=11) and CD14 260TT (n=33) genotypes (p=0.016 and p=0.026, respectively).CONCLUSION: In patients with stable coronary artery disease the CRP 1444TT and CD14 260TT variants are associated with larger coronary plaque volume independently of concomitant cardiovascular risk factors.

KW - Aged

KW - C-Reactive Protein/genetics

KW - Chi-Square Distribution

KW - Coronary Artery Disease/diagnostic imaging

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Heterozygote

KW - Humans

KW - Inflammation Mediators

KW - Lipopolysaccharide Receptors/genetics

KW - Male

KW - Middle Aged

KW - Phenotype

KW - Plaque, Atherosclerotic/diagnostic imaging

KW - Polymerase Chain Reaction

KW - Polymorphism, Single Nucleotide

KW - Randomized Controlled Trials as Topic

KW - Retrospective Studies

KW - Risk Assessment

KW - Risk Factors

KW - Ultrasonography, Interventional

U2 - 10.1016/j.atherosclerosis.2011.10.019

DO - 10.1016/j.atherosclerosis.2011.10.019

M3 - SCORING: Journal article

C2 - 22056216

VL - 220

SP - 172

EP - 176

JO - ATHEROSCLEROSIS

JF - ATHEROSCLEROSIS

SN - 0021-9150

IS - 1

ER -