Crosstalk of the plasma contact system with bacteria.
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Crosstalk of the plasma contact system with bacteria. / Nickel, Katrin Faye; Renné, Thomas.
in: THROMB RES, Jahrgang 130 Suppl 1, 2012, S. 78-83.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Crosstalk of the plasma contact system with bacteria.
AU - Nickel, Katrin Faye
AU - Renné, Thomas
PY - 2012
Y1 - 2012
N2 - Activation of the plasma contact system triggers several cascade systems such as the kallikrein-kinin system, the intrinsic pathway of coagulation, the classical complement cascade and the fibrinolytic system. Recent studies have shown a critical role of the contact system for arterial and venous thrombus formation and thromboembolic disease. In contrast, the function of the contact system for host-defense reactions and its physiological functions have remained enigmatic. Experimental animal studies and clinical data have linked the contact system to bacterial infections with implications for sepsis disease. The present review summarizes the role of the contact system and its activation for bacterial infections.
AB - Activation of the plasma contact system triggers several cascade systems such as the kallikrein-kinin system, the intrinsic pathway of coagulation, the classical complement cascade and the fibrinolytic system. Recent studies have shown a critical role of the contact system for arterial and venous thrombus formation and thromboembolic disease. In contrast, the function of the contact system for host-defense reactions and its physiological functions have remained enigmatic. Experimental animal studies and clinical data have linked the contact system to bacterial infections with implications for sepsis disease. The present review summarizes the role of the contact system and its activation for bacterial infections.
KW - Animals
KW - Humans
KW - Immunity, Innate
KW - Signal Transduction
KW - Bacteria/immunology/metabolism
KW - Bacterial Infections/blood/complications/immunology/microbiology
KW - Blood Coagulation
KW - Capillary Permeability
KW - Complement Pathway, Classical
KW - Fibrin/metabolism
KW - Fibrinolysis
KW - Kallikrein-Kinin System
KW - Sepsis/blood/immunology/microbiology
KW - Animals
KW - Humans
KW - Immunity, Innate
KW - Signal Transduction
KW - Bacteria/immunology/metabolism
KW - Bacterial Infections/blood/complications/immunology/microbiology
KW - Blood Coagulation
KW - Capillary Permeability
KW - Complement Pathway, Classical
KW - Fibrin/metabolism
KW - Fibrinolysis
KW - Kallikrein-Kinin System
KW - Sepsis/blood/immunology/microbiology
M3 - SCORING: Journal article
VL - 130 Suppl 1
SP - 78
EP - 83
JO - THROMB RES
JF - THROMB RES
SN - 0049-3848
ER -
