Cross-sectional Study of Glutamate in the Anterior Cingulate and Hippocampus in Schizophrenia
Standard
Cross-sectional Study of Glutamate in the Anterior Cingulate and Hippocampus in Schizophrenia. / Gallinat, Jürgen; McMahon, Kibby; Kühn, Simone; Schubert, Florian; Schaefer, Martin.
in: SCHIZOPHRENIA BULL, Jahrgang 42, Nr. 2, 2016, S. 425-433.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Cross-sectional Study of Glutamate in the Anterior Cingulate and Hippocampus in Schizophrenia
AU - Gallinat, Jürgen
AU - McMahon, Kibby
AU - Kühn, Simone
AU - Schubert, Florian
AU - Schaefer, Martin
N1 - © The Author 2015. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.
PY - 2016
Y1 - 2016
N2 - BACKGROUND: There has been growing support for dysfunctions of the excitatory glutamatergic system and its implications for the psychophysiology of schizophrenia. However, previous studies reported mixed results regarding glutamate concentrations in schizophrenia with varying deviations across brain regions.METHODS: We used an optimized proton magnetic resonance spectroscopy procedure to measure absolute glutamate concentrations in the left hippocampal region and the anterior cingulate cortex (ACC) in 29 medicated patients with schizophrenia and in 29 control participants without mental disorder.RESULTS: The glutamate concentrations were significantly lower in the ACC but higher in the hippocampus of patients compared to controls. ACC and hippocampal glutamate concentrations correlated positively in patients but not in controls. ACC glutamate was weakly associated with Clinical Global Impression score and duration of illness in patients.CONCLUSION: Glutamate concentrations in schizophrenia deviate from controls and show associations with disease severity. A higher concentration of hippocampal glutamate in schizophrenia compared to controls is shown. The association between ACC and hippocampus glutamate concentrations in patients with schizophrenia suggests an abnormal coupling of excitatory systems compared to controls as predicted by previous glutamate models of schizophrenia.
AB - BACKGROUND: There has been growing support for dysfunctions of the excitatory glutamatergic system and its implications for the psychophysiology of schizophrenia. However, previous studies reported mixed results regarding glutamate concentrations in schizophrenia with varying deviations across brain regions.METHODS: We used an optimized proton magnetic resonance spectroscopy procedure to measure absolute glutamate concentrations in the left hippocampal region and the anterior cingulate cortex (ACC) in 29 medicated patients with schizophrenia and in 29 control participants without mental disorder.RESULTS: The glutamate concentrations were significantly lower in the ACC but higher in the hippocampus of patients compared to controls. ACC and hippocampal glutamate concentrations correlated positively in patients but not in controls. ACC glutamate was weakly associated with Clinical Global Impression score and duration of illness in patients.CONCLUSION: Glutamate concentrations in schizophrenia deviate from controls and show associations with disease severity. A higher concentration of hippocampal glutamate in schizophrenia compared to controls is shown. The association between ACC and hippocampus glutamate concentrations in patients with schizophrenia suggests an abnormal coupling of excitatory systems compared to controls as predicted by previous glutamate models of schizophrenia.
U2 - 10.1093/schbul/sbv124
DO - 10.1093/schbul/sbv124
M3 - SCORING: Journal article
C2 - 26333842
VL - 42
SP - 425
EP - 433
JO - SCHIZOPHRENIA BULL
JF - SCHIZOPHRENIA BULL
SN - 0586-7614
IS - 2
ER -
