PortalPublikationenCritical role of leukocyte function-associated antigen-1 in ...

Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells

Standard

Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells. / Emoto, M; Mittrücker, H W; Schmits, R; Mak, T W; Kaufmann, S H.

in: J IMMUNOL, Jahrgang 162, Nr. 9, 01.05.1999, S. 5094-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Emoto, M, Mittrücker, HW, Schmits, R, Mak, TW & Kaufmann, SH 1999, 'Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells', J IMMUNOL, Jg. 162, Nr. 9, S. 5094-8.

APA

Emoto, M., Mittrücker, H. W., Schmits, R., Mak, T. W., & Kaufmann, S. H. (1999). Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells. J IMMUNOL, 162(9), 5094-8.

Vancouver

Emoto M, Mittrücker HW, Schmits R, Mak TW, Kaufmann SH. Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells. J IMMUNOL. 1999 Mai 1;162(9):5094-8.

Bibtex

@article{104aed4a48754a4b931804743c3dc252,
title = "Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells",
abstract = "In contrast to peripheral lymphoid organs, a high percentage of T cells in the liver are CD4+NKT cells. We asked whether adhesion molecules play any role in the accumulation of CD4+NKT cells in the liver. Liver CD4+NKT cells expressed ICAM-1 and high levels of LFA-1. In the livers of LFA-1-deficient mice, the number of CD4+NKT cells was markedly decreased. This reduction was restricted to the liver, and no reduction was found in the other organs analyzed. In contrast, the number of liver CD4+NKT cells in ICAM-1-deficient mice was only marginally reduced. In a reciprocal radiation thymocyte reconstitution system with LFA-1-deficient and wild-type mice, LFA-1 expressed on liver cells other than CD4+NKT cells was required for an accumulation of CD4+NKT cells in the liver. These results demonstrate a crucial role for LFA-1 in the accumulation of CD4+NKT cells in the liver.",
keywords = "Adoptive Transfer, Animals, Antigens, Antigens, Surface, CD4-Positive T-Lymphocytes, Cell Movement, Intercellular Adhesion Molecule-1, Killer Cells, Natural, Lectins, C-Type, Liver, Lymphocyte Function-Associated Antigen-1, Lymphoid Tissue, Mice, Mice, Congenic, Mice, Inbred C57BL, Mice, Mutant Strains, Mice, SCID, NK Cell Lectin-Like Receptor Subfamily B, Protein Biosynthesis, Proteins, Radiation Chimera, T-Lymphocyte Subsets, Thymus Gland",
author = "M Emoto and Mittr{\"u}cker, {H W} and R Schmits and Mak, {T W} and Kaufmann, {S H}",
year = "1999",
month = may,
day = "1",
language = "English",
volume = "162",
pages = "5094--8",
journal = "J IMMUNOL",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "9",

}

RIS

TY - JOUR

T1 - Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells

AU - Emoto, M

AU - Mittrücker, H W

AU - Schmits, R

AU - Mak, T W

AU - Kaufmann, S H

PY - 1999/5/1

Y1 - 1999/5/1

N2 - In contrast to peripheral lymphoid organs, a high percentage of T cells in the liver are CD4+NKT cells. We asked whether adhesion molecules play any role in the accumulation of CD4+NKT cells in the liver. Liver CD4+NKT cells expressed ICAM-1 and high levels of LFA-1. In the livers of LFA-1-deficient mice, the number of CD4+NKT cells was markedly decreased. This reduction was restricted to the liver, and no reduction was found in the other organs analyzed. In contrast, the number of liver CD4+NKT cells in ICAM-1-deficient mice was only marginally reduced. In a reciprocal radiation thymocyte reconstitution system with LFA-1-deficient and wild-type mice, LFA-1 expressed on liver cells other than CD4+NKT cells was required for an accumulation of CD4+NKT cells in the liver. These results demonstrate a crucial role for LFA-1 in the accumulation of CD4+NKT cells in the liver.

AB - In contrast to peripheral lymphoid organs, a high percentage of T cells in the liver are CD4+NKT cells. We asked whether adhesion molecules play any role in the accumulation of CD4+NKT cells in the liver. Liver CD4+NKT cells expressed ICAM-1 and high levels of LFA-1. In the livers of LFA-1-deficient mice, the number of CD4+NKT cells was markedly decreased. This reduction was restricted to the liver, and no reduction was found in the other organs analyzed. In contrast, the number of liver CD4+NKT cells in ICAM-1-deficient mice was only marginally reduced. In a reciprocal radiation thymocyte reconstitution system with LFA-1-deficient and wild-type mice, LFA-1 expressed on liver cells other than CD4+NKT cells was required for an accumulation of CD4+NKT cells in the liver. These results demonstrate a crucial role for LFA-1 in the accumulation of CD4+NKT cells in the liver.

KW - Adoptive Transfer

KW - Animals

KW - Antigens

KW - Antigens, Surface

KW - CD4-Positive T-Lymphocytes

KW - Cell Movement

KW - Intercellular Adhesion Molecule-1

KW - Killer Cells, Natural

KW - Lectins, C-Type

KW - Liver

KW - Lymphocyte Function-Associated Antigen-1

KW - Lymphoid Tissue

KW - Mice

KW - Mice, Congenic

KW - Mice, Inbred C57BL

KW - Mice, Mutant Strains

KW - Mice, SCID

KW - NK Cell Lectin-Like Receptor Subfamily B

KW - Protein Biosynthesis

KW - Proteins

KW - Radiation Chimera

KW - T-Lymphocyte Subsets

KW - Thymus Gland

M3 - SCORING: Journal article

C2 - 10227978

VL - 162

SP - 5094

EP - 5098

JO - J IMMUNOL

JF - J IMMUNOL

SN - 0022-1767

IS - 9

ER -