Critical comments to a recent EFLM recommendation for the review of reference intervals
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Critical comments to a recent EFLM recommendation for the review of reference intervals. / Haeckel, Rainer; Wosniok, Werner; Arzideh, Farhad; Zierk, Jakob; Gurr, Eberhard; Streichert, Thomas.
in: CLIN CHEM LAB MED, Jahrgang 55, Nr. 3, 01.03.2017, S. 341-347.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Critical comments to a recent EFLM recommendation for the review of reference intervals
AU - Haeckel, Rainer
AU - Wosniok, Werner
AU - Arzideh, Farhad
AU - Zierk, Jakob
AU - Gurr, Eberhard
AU - Streichert, Thomas
PY - 2017/3/1
Y1 - 2017/3/1
N2 - In a recent EFLM recommendation on reference intervals by Henny et al., the direct approach for determining reference intervals was proposed as the only presently accepted "gold" standard. Some essential drawbacks of the direct approach were not sufficiently emphasized, such as unacceptably wide confidence limits due to the limited number of observations claimed and the practical usability for only a limited age range. Indirect procedures avoid these disadvantages of the direct approach. Furthermore, indirect approaches are well suited for reference limits with large variations during lifetime and for common reference limits.
AB - In a recent EFLM recommendation on reference intervals by Henny et al., the direct approach for determining reference intervals was proposed as the only presently accepted "gold" standard. Some essential drawbacks of the direct approach were not sufficiently emphasized, such as unacceptably wide confidence limits due to the limited number of observations claimed and the practical usability for only a limited age range. Indirect procedures avoid these disadvantages of the direct approach. Furthermore, indirect approaches are well suited for reference limits with large variations during lifetime and for common reference limits.
KW - Age Factors
KW - Clinical Chemistry Tests
KW - Europe
KW - Humans
KW - Medical Laboratory Science
KW - Reference Standards
KW - Reference Values
KW - Journal Article
KW - Review
U2 - 10.1515/cclm-2016-1112
DO - 10.1515/cclm-2016-1112
M3 - SCORING: Review article
C2 - 28151722
VL - 55
SP - 341
EP - 347
JO - CLIN CHEM LAB MED
JF - CLIN CHEM LAB MED
SN - 1434-6621
IS - 3
ER -