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C-reactive protein independently predicts survival in pancreatic neuroendocrine neoplasms

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C-reactive protein independently predicts survival in pancreatic neuroendocrine neoplasms. / Nießen, Anna; Schimmack, Simon; Sandini, Marta; Fliegner, Dominik; Hinz, Ulf; Lewosinska, Magdalena; Hackert, Thilo; Büchler, Markus W; Strobel, Oliver.

in: SCI REP-UK, Jahrgang 11, Nr. 1, 09.12.2021, S. 23768.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Nießen, A, Schimmack, S, Sandini, M, Fliegner, D, Hinz, U, Lewosinska, M, Hackert, T, Büchler, MW & Strobel, O 2021, 'C-reactive protein independently predicts survival in pancreatic neuroendocrine neoplasms', SCI REP-UK, Jg. 11, Nr. 1, S. 23768. https://doi.org/10.1038/s41598-021-03187-x

APA

Nießen, A., Schimmack, S., Sandini, M., Fliegner, D., Hinz, U., Lewosinska, M., Hackert, T., Büchler, M. W., & Strobel, O. (2021). C-reactive protein independently predicts survival in pancreatic neuroendocrine neoplasms. SCI REP-UK, 11(1), 23768. https://doi.org/10.1038/s41598-021-03187-x

Vancouver

Nießen A, Schimmack S, Sandini M, Fliegner D, Hinz U, Lewosinska M et al. C-reactive protein independently predicts survival in pancreatic neuroendocrine neoplasms. SCI REP-UK. 2021 Dez 9;11(1):23768. https://doi.org/10.1038/s41598-021-03187-x

Bibtex

@article{5de2aeca2e8244df99c6e9efcba7ff6e,
title = "C-reactive protein independently predicts survival in pancreatic neuroendocrine neoplasms",
abstract = "Pancreatic neuroendocrine neoplasms (pNEN) are highly variable in their postresection survival. Determination of preoperative risk factors is essential for treatment strategies. C-reactive protein (CRP) has been implicated in the pathogenesis of pNEN and shown to be associated with survival in different tumour entities. Patients undergoing surgery for pNEN were retrospectively analysed. Patients were divided into three subgroups according to preoperative CRP serum levels. Clinicopathological features, overall and disease-free survival were assessed. Uni- and multivariable survival analyses were performed. 517 surgically resected pNEN patients were analysed. CRP levels were significantly associated with relevant clinicopathological parameters and prognosis and were able to stratify subgroups with significant and clinically relevant differences in overall and disease-free survival. In univariable sensitivity analyses CRP was confirmed as a prognostic factor for overall survival in subgroups with G2 differentiation, T1/T2 and T3/T4 tumour stages, patients with node positive disease and with and without distant metastases. By multivariable analysis, preoperative CRP was confirmed as an independent predictor of postresection survival together with patient age and the established postoperative pathological predictors grading, T-stage and metastases. Preoperative serum CRP is a strong predictive biomarker for both overall and disease free survival of surgically resected pNEN. CRP is associated with prognosis independently of grading and tumour stage and may be of additional use for treatment decisions.",
keywords = "Aged, Biomarkers, Tumor, C-Reactive Protein, Carcinoma, Neuroendocrine/blood, Female, Follow-Up Studies, Humans, Male, Middle Aged, Multivariate Analysis, Neoplasm Grading, Neoplasm Staging, Pancreatic Neoplasms/blood, Prognosis, Proportional Hazards Models, ROC Curve",
author = "Anna Nie{\ss}en and Simon Schimmack and Marta Sandini and Dominik Fliegner and Ulf Hinz and Magdalena Lewosinska and Thilo Hackert and B{\"u}chler, {Markus W} and Oliver Strobel",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = dec,
day = "9",
doi = "10.1038/s41598-021-03187-x",
language = "English",
volume = "11",
pages = "23768",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - C-reactive protein independently predicts survival in pancreatic neuroendocrine neoplasms

AU - Nießen, Anna

AU - Schimmack, Simon

AU - Sandini, Marta

AU - Fliegner, Dominik

AU - Hinz, Ulf

AU - Lewosinska, Magdalena

AU - Hackert, Thilo

AU - Büchler, Markus W

AU - Strobel, Oliver

N1 - © 2021. The Author(s).

PY - 2021/12/9

Y1 - 2021/12/9

N2 - Pancreatic neuroendocrine neoplasms (pNEN) are highly variable in their postresection survival. Determination of preoperative risk factors is essential for treatment strategies. C-reactive protein (CRP) has been implicated in the pathogenesis of pNEN and shown to be associated with survival in different tumour entities. Patients undergoing surgery for pNEN were retrospectively analysed. Patients were divided into three subgroups according to preoperative CRP serum levels. Clinicopathological features, overall and disease-free survival were assessed. Uni- and multivariable survival analyses were performed. 517 surgically resected pNEN patients were analysed. CRP levels were significantly associated with relevant clinicopathological parameters and prognosis and were able to stratify subgroups with significant and clinically relevant differences in overall and disease-free survival. In univariable sensitivity analyses CRP was confirmed as a prognostic factor for overall survival in subgroups with G2 differentiation, T1/T2 and T3/T4 tumour stages, patients with node positive disease and with and without distant metastases. By multivariable analysis, preoperative CRP was confirmed as an independent predictor of postresection survival together with patient age and the established postoperative pathological predictors grading, T-stage and metastases. Preoperative serum CRP is a strong predictive biomarker for both overall and disease free survival of surgically resected pNEN. CRP is associated with prognosis independently of grading and tumour stage and may be of additional use for treatment decisions.

AB - Pancreatic neuroendocrine neoplasms (pNEN) are highly variable in their postresection survival. Determination of preoperative risk factors is essential for treatment strategies. C-reactive protein (CRP) has been implicated in the pathogenesis of pNEN and shown to be associated with survival in different tumour entities. Patients undergoing surgery for pNEN were retrospectively analysed. Patients were divided into three subgroups according to preoperative CRP serum levels. Clinicopathological features, overall and disease-free survival were assessed. Uni- and multivariable survival analyses were performed. 517 surgically resected pNEN patients were analysed. CRP levels were significantly associated with relevant clinicopathological parameters and prognosis and were able to stratify subgroups with significant and clinically relevant differences in overall and disease-free survival. In univariable sensitivity analyses CRP was confirmed as a prognostic factor for overall survival in subgroups with G2 differentiation, T1/T2 and T3/T4 tumour stages, patients with node positive disease and with and without distant metastases. By multivariable analysis, preoperative CRP was confirmed as an independent predictor of postresection survival together with patient age and the established postoperative pathological predictors grading, T-stage and metastases. Preoperative serum CRP is a strong predictive biomarker for both overall and disease free survival of surgically resected pNEN. CRP is associated with prognosis independently of grading and tumour stage and may be of additional use for treatment decisions.

KW - Aged

KW - Biomarkers, Tumor

KW - C-Reactive Protein

KW - Carcinoma, Neuroendocrine/blood

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Neoplasm Grading

KW - Neoplasm Staging

KW - Pancreatic Neoplasms/blood

KW - Prognosis

KW - Proportional Hazards Models

KW - ROC Curve

U2 - 10.1038/s41598-021-03187-x

DO - 10.1038/s41598-021-03187-x

M3 - SCORING: Journal article

C2 - 34887479

VL - 11

SP - 23768

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

ER -