COVID-19 vaccination in patients with multiple myeloma: a consensus of the European Myeloma Network
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COVID-19 vaccination in patients with multiple myeloma: a consensus of the European Myeloma Network. / Ludwig, Heinz; Sonneveld, Pieter; Facon, Thierry; San-Miguel, Jesus; Avet-Loiseau, Hervé; Mohty, Mohamad; Mateos, Maria-Victoria; Moreau, Philippe; Cavo, Michele; Pawlyn, Charlotte; Zweegman, Sonja; Engelhardt, Monika; Driessen, Christoph; Cook, Gordon; Dimopoulos, Melitios A; Gay, Francesca; Einsele, Hermann; Delforge, Michel; Caers, Jo; Weisel, Katja; Jackson, Graham; Garderet, Laurent; van de Donk, Niels; Leleu, Xavier; Goldschmidt, Hartmut; Beksac, Meral; Nijhof, Inger; Schreder, Martin; Abildgaard, Niels; Hajek, Roman; Zojer, Niklas; Kastritis, Efstathios; Broijl, Annemiek; Schjesvold, Fredrik; Boccadoro, Mario; Terpos, Evangelos.
in: LANCET HAEMATOL, Jahrgang 8, Nr. 12, 12.2021, S. e934-e946.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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T1 - COVID-19 vaccination in patients with multiple myeloma: a consensus of the European Myeloma Network
AU - Ludwig, Heinz
AU - Sonneveld, Pieter
AU - Facon, Thierry
AU - San-Miguel, Jesus
AU - Avet-Loiseau, Hervé
AU - Mohty, Mohamad
AU - Mateos, Maria-Victoria
AU - Moreau, Philippe
AU - Cavo, Michele
AU - Pawlyn, Charlotte
AU - Zweegman, Sonja
AU - Engelhardt, Monika
AU - Driessen, Christoph
AU - Cook, Gordon
AU - Dimopoulos, Melitios A
AU - Gay, Francesca
AU - Einsele, Hermann
AU - Delforge, Michel
AU - Caers, Jo
AU - Weisel, Katja
AU - Jackson, Graham
AU - Garderet, Laurent
AU - van de Donk, Niels
AU - Leleu, Xavier
AU - Goldschmidt, Hartmut
AU - Beksac, Meral
AU - Nijhof, Inger
AU - Schreder, Martin
AU - Abildgaard, Niels
AU - Hajek, Roman
AU - Zojer, Niklas
AU - Kastritis, Efstathios
AU - Broijl, Annemiek
AU - Schjesvold, Fredrik
AU - Boccadoro, Mario
AU - Terpos, Evangelos
N1 - Crown Copyright © 2021 Published by Elsevier Ltd. All rights reserved.
PY - 2021/12
Y1 - 2021/12
N2 - Patients with multiple myeloma frequently present with substantial immune impairment and an increased risk for infections and infection-related mortality. The risk for infection with SARS-CoV-2 virus and resulting mortality is also increased, emphasising the importance of protecting patients by vaccination. Available data in patients with multiple myeloma suggest a suboptimal anti-SARS-CoV-2 immune response, meaning a proportion of patients are unprotected. Factors associated with poor response are uncontrolled disease, immunosuppression, concomitant therapy, more lines of therapy, and CD38 antibody-directed and B-cell maturation antigen-directed therapy. These facts suggest that monitoring the immune response to vaccination in patients with multiple myeloma might provide guidance for clinical management, such as administration of additional doses of the same or another vaccine, or even temporary treatment discontinuation, if possible. In those who do not exhibit a good response, prophylactic treatment with neutralising monoclonal antibody cocktails might be considered. In patients deficient of a SARS-CoV-2 immune response, adherence to measures for infection risk reduction is particularly recommended. This consensus was generated by members of the European Multiple Myeloma Network and some external experts. The panel members convened in virtual meetings and conducted an extensive literature research and evaluated recently published data and work presented at meetings, as well as findings from their own studies. The outcome of the discussions on establishing consensus recommendations for COVID-19 vaccination in patients with multiple myeloma was condensed into this Review.
AB - Patients with multiple myeloma frequently present with substantial immune impairment and an increased risk for infections and infection-related mortality. The risk for infection with SARS-CoV-2 virus and resulting mortality is also increased, emphasising the importance of protecting patients by vaccination. Available data in patients with multiple myeloma suggest a suboptimal anti-SARS-CoV-2 immune response, meaning a proportion of patients are unprotected. Factors associated with poor response are uncontrolled disease, immunosuppression, concomitant therapy, more lines of therapy, and CD38 antibody-directed and B-cell maturation antigen-directed therapy. These facts suggest that monitoring the immune response to vaccination in patients with multiple myeloma might provide guidance for clinical management, such as administration of additional doses of the same or another vaccine, or even temporary treatment discontinuation, if possible. In those who do not exhibit a good response, prophylactic treatment with neutralising monoclonal antibody cocktails might be considered. In patients deficient of a SARS-CoV-2 immune response, adherence to measures for infection risk reduction is particularly recommended. This consensus was generated by members of the European Multiple Myeloma Network and some external experts. The panel members convened in virtual meetings and conducted an extensive literature research and evaluated recently published data and work presented at meetings, as well as findings from their own studies. The outcome of the discussions on establishing consensus recommendations for COVID-19 vaccination in patients with multiple myeloma was condensed into this Review.
U2 - 10.1016/S2352-3026(21)00278-7
DO - 10.1016/S2352-3026(21)00278-7
M3 - SCORING: Review article
C2 - 34756169
VL - 8
SP - e934-e946
JO - LANCET HAEMATOL
JF - LANCET HAEMATOL
SN - 2352-3026
IS - 12
ER -
