COVID-19 effects on the kidney
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COVID-19 effects on the kidney. / Amann, K; Boor, P; Wiech, T; Singh, J; Vonbrunn, E; Knöll, A; Hermann, M; Büttner-Herold, M; Daniel, C; Hartmann, A.
in: PATHOLOGE, Jahrgang 42, Nr. Suppl 1, 11.2021, S. 76-80.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - COVID-19 effects on the kidney
AU - Amann, K
AU - Boor, P
AU - Wiech, T
AU - Singh, J
AU - Vonbrunn, E
AU - Knöll, A
AU - Hermann, M
AU - Büttner-Herold, M
AU - Daniel, C
AU - Hartmann, A
N1 - © 2021. Springer Medizin Verlag GmbH, ein Teil von Springer Nature.
PY - 2021/11
Y1 - 2021/11
N2 - Apart from pulmonary disease, acute kidney injury (AKI) is one of the most frequent and most severe organ complications in severe coronavirus disease 2019 (COVID-19). The SARS-CoV‑2 virus has been detected in renal tissue. Patients with chronic kidney disease (CKD) before and on dialysis and specifically renal transplant patients represent a particularly vulnerable population. The increasing number of COVID-19 infected patients with renal involvement led to an evolving interest in the analysis of its pathophysiology, morphology and modes of virus detection in the kidney. Meanwhile, there are ample data from several autopsy and kidney biopsy studies that differ in the quantity of cases as well as in their quality. While the detection of SARS-CoV‑2 RNA in the kidney leads to reproducible results, the use of electron microscopy for visualisation of the virus is difficult and currently critically discussed due to various artefacts. The exact contribution of indirect or direct effects on the kidney in COVID-19 are not yet known and are currently the focus of intensive research.
AB - Apart from pulmonary disease, acute kidney injury (AKI) is one of the most frequent and most severe organ complications in severe coronavirus disease 2019 (COVID-19). The SARS-CoV‑2 virus has been detected in renal tissue. Patients with chronic kidney disease (CKD) before and on dialysis and specifically renal transplant patients represent a particularly vulnerable population. The increasing number of COVID-19 infected patients with renal involvement led to an evolving interest in the analysis of its pathophysiology, morphology and modes of virus detection in the kidney. Meanwhile, there are ample data from several autopsy and kidney biopsy studies that differ in the quantity of cases as well as in their quality. While the detection of SARS-CoV‑2 RNA in the kidney leads to reproducible results, the use of electron microscopy for visualisation of the virus is difficult and currently critically discussed due to various artefacts. The exact contribution of indirect or direct effects on the kidney in COVID-19 are not yet known and are currently the focus of intensive research.
KW - Acute Kidney Injury
KW - COVID-19
KW - Humans
KW - Kidney
KW - RNA, Viral
KW - SARS-CoV-2
U2 - 10.1007/s00292-020-00900-x
DO - 10.1007/s00292-020-00900-x
M3 - SCORING: Review article
C2 - 33646362
VL - 42
SP - 76
EP - 80
JO - PATHOLOGE
JF - PATHOLOGE
SN - 0172-8113
IS - Suppl 1
ER -