Cortico-subcortical activation patterns for itch and pain imagery

Hideki Mochizuki; Ulf Baumgärtner; Sandra Kamping; Michaela Ruttorf; Lothar R Schad; Herta Flor; Ryusuke Kakigi; Rolf-Detlef Treede

doi:10.1016/j.pain.2013.06.007

Cortico-subcortical activation patterns for itch and pain imagery

Standard

Cortico-subcortical activation patterns for itch and pain imagery. / Mochizuki, Hideki; Baumgärtner, Ulf; Kamping, Sandra; Ruttorf, Michaela; Schad, Lothar R; Flor, Herta; Kakigi, Ryusuke; Treede, Rolf-Detlef.

in: PAIN, Jahrgang 154, Nr. 10, 10.2013, S. 1989-98.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mochizuki, H, Baumgärtner, U, Kamping, S, Ruttorf, M, Schad, LR, Flor, H, Kakigi, R & Treede, R-D 2013, 'Cortico-subcortical activation patterns for itch and pain imagery', PAIN, Jg. 154, Nr. 10, S. 1989-98. https://doi.org/10.1016/j.pain.2013.06.007

APA

Mochizuki, H., Baumgärtner, U., Kamping, S., Ruttorf, M., Schad, L. R., Flor, H., Kakigi, R., & Treede, R-D. (2013). Cortico-subcortical activation patterns for itch and pain imagery. PAIN, 154(10), 1989-98. https://doi.org/10.1016/j.pain.2013.06.007

Vancouver

Mochizuki H, Baumgärtner U, Kamping S, Ruttorf M, Schad LR, Flor H et al. Cortico-subcortical activation patterns for itch and pain imagery. PAIN. 2013 Okt;154(10):1989-98. https://doi.org/10.1016/j.pain.2013.06.007

Bibtex

@article{1be99054d80741dda6ee1fa1cc3dd92b,

title = "Cortico-subcortical activation patterns for itch and pain imagery",

abstract = "The imagery of itch and pain evokes emotional responses and covert motor responses (scratching to itch and withdrawal to pain). This suggests some similarity in cerebral mechanisms. However, itch is more socially contagious than pain, as evidenced by the fact that scratching behaviors can be easily initiated by watching itch-inducing situations, whereas withdrawal is less easily initiated by watching painful situations. Thus, we assumed that the cerebral mechanisms of itch imagery partly differ from those of pain imagery in particular with respect to motor regions. We addressed this issue in 18 healthy subjects using functional magnetic resonance imaging. The subjects were instructed to imagine itch and pain sensations in their own bodies while viewing pictures depicting stimuli associated with these sensations. Itch and pain imagery activated the anterior insular cortex (aIC) and motor-related regions such as supplementary motor area, basal ganglia, thalamus, and cerebellum. Activity in these regions was not significantly different between itch and pain imagery. However, functional connectivity between motor-related regions and the aIC showed marked differences between itch and pain imagery. Connectivity with the aIC was stronger in the primary motor and premotor cortices during pain imagery and stronger in the globus pallidus during itch imagery. These findings indicate that brain regions associated with imagery of itch are the same as those involved in imagery of pain, but their functional networks differ. These differences in brain networks may explain why motor responses to itch are more socially contagious than those related to pain.",

keywords = "Adult, Brain Mapping, Cerebral Cortex, Female, Humans, Imagination, Magnetic Resonance Imaging, Male, Nerve Net, Pain, Photic Stimulation, Pilot Projects, Pruritus, Young Adult",

author = "Hideki Mochizuki and Ulf Baumg{\"a}rtner and Sandra Kamping and Michaela Ruttorf and Schad, {Lothar R} and Herta Flor and Ryusuke Kakigi and Rolf-Detlef Treede",

year = "2013",

month = oct,

doi = "10.1016/j.pain.2013.06.007",

language = "English",

volume = "154",

pages = "1989--98",

journal = "PAIN",

issn = "0304-3959",

publisher = "Elsevier",

number = "10",

}

RIS

TY - JOUR

T1 - Cortico-subcortical activation patterns for itch and pain imagery

AU - Mochizuki, Hideki

AU - Baumgärtner, Ulf

AU - Kamping, Sandra

AU - Ruttorf, Michaela

AU - Schad, Lothar R

AU - Flor, Herta

AU - Kakigi, Ryusuke

AU - Treede, Rolf-Detlef

PY - 2013/10

Y1 - 2013/10

N2 - The imagery of itch and pain evokes emotional responses and covert motor responses (scratching to itch and withdrawal to pain). This suggests some similarity in cerebral mechanisms. However, itch is more socially contagious than pain, as evidenced by the fact that scratching behaviors can be easily initiated by watching itch-inducing situations, whereas withdrawal is less easily initiated by watching painful situations. Thus, we assumed that the cerebral mechanisms of itch imagery partly differ from those of pain imagery in particular with respect to motor regions. We addressed this issue in 18 healthy subjects using functional magnetic resonance imaging. The subjects were instructed to imagine itch and pain sensations in their own bodies while viewing pictures depicting stimuli associated with these sensations. Itch and pain imagery activated the anterior insular cortex (aIC) and motor-related regions such as supplementary motor area, basal ganglia, thalamus, and cerebellum. Activity in these regions was not significantly different between itch and pain imagery. However, functional connectivity between motor-related regions and the aIC showed marked differences between itch and pain imagery. Connectivity with the aIC was stronger in the primary motor and premotor cortices during pain imagery and stronger in the globus pallidus during itch imagery. These findings indicate that brain regions associated with imagery of itch are the same as those involved in imagery of pain, but their functional networks differ. These differences in brain networks may explain why motor responses to itch are more socially contagious than those related to pain.

AB - The imagery of itch and pain evokes emotional responses and covert motor responses (scratching to itch and withdrawal to pain). This suggests some similarity in cerebral mechanisms. However, itch is more socially contagious than pain, as evidenced by the fact that scratching behaviors can be easily initiated by watching itch-inducing situations, whereas withdrawal is less easily initiated by watching painful situations. Thus, we assumed that the cerebral mechanisms of itch imagery partly differ from those of pain imagery in particular with respect to motor regions. We addressed this issue in 18 healthy subjects using functional magnetic resonance imaging. The subjects were instructed to imagine itch and pain sensations in their own bodies while viewing pictures depicting stimuli associated with these sensations. Itch and pain imagery activated the anterior insular cortex (aIC) and motor-related regions such as supplementary motor area, basal ganglia, thalamus, and cerebellum. Activity in these regions was not significantly different between itch and pain imagery. However, functional connectivity between motor-related regions and the aIC showed marked differences between itch and pain imagery. Connectivity with the aIC was stronger in the primary motor and premotor cortices during pain imagery and stronger in the globus pallidus during itch imagery. These findings indicate that brain regions associated with imagery of itch are the same as those involved in imagery of pain, but their functional networks differ. These differences in brain networks may explain why motor responses to itch are more socially contagious than those related to pain.

KW - Adult

KW - Brain Mapping

KW - Cerebral Cortex

KW - Female

KW - Humans

KW - Imagination

KW - Magnetic Resonance Imaging

KW - Male

KW - Nerve Net

KW - Pain

KW - Photic Stimulation

KW - Pilot Projects

KW - Pruritus

KW - Young Adult

U2 - 10.1016/j.pain.2013.06.007

DO - 10.1016/j.pain.2013.06.007

M3 - SCORING: Journal article

C2 - 23769719

VL - 154

SP - 1989

EP - 1998

JO - PAIN

JF - PAIN

SN - 0304-3959

IS - 10

ER -