[Cortical dysbalance in the brain in migraineurs--hyperexcitability as the result of sensitisation?]
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[Cortical dysbalance in the brain in migraineurs--hyperexcitability as the result of sensitisation?]. / Stankewitz, Anne; May, Arne.
in: SCHMERZ, Jahrgang 22, Nr. 1, 1, 2008, S. 17-21.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - [Cortical dysbalance in the brain in migraineurs--hyperexcitability as the result of sensitisation?]
AU - Stankewitz, Anne
AU - May, Arne
PY - 2008
Y1 - 2008
N2 - A cortical dysbalance has a pivotal role in the pathophysiology of migraine. Numerous electrophysiological and transcranial magnetic stimulation (TMS) studies have investigated the interictal excitability level in migraineurs and have shown a consistent lack of habituation during repetitive stimulation. There is some controversy in the current literature over whether this deficit is based on a lowered or an elevated preactivation level. However, the current discussion may be misguided. It seems that multiple external and intrinsic factors influence the level of cortical excitability and the frequency and intensity of attacks: Habituation is specific neither to migraine nor even to pain; the same phenomenon is found in tinnitus patients, for example. Cortical hyperexcitability is presumably the result of chronicity and the concomitant central sensitisation process.
AB - A cortical dysbalance has a pivotal role in the pathophysiology of migraine. Numerous electrophysiological and transcranial magnetic stimulation (TMS) studies have investigated the interictal excitability level in migraineurs and have shown a consistent lack of habituation during repetitive stimulation. There is some controversy in the current literature over whether this deficit is based on a lowered or an elevated preactivation level. However, the current discussion may be misguided. It seems that multiple external and intrinsic factors influence the level of cortical excitability and the frequency and intensity of attacks: Habituation is specific neither to migraine nor even to pain; the same phenomenon is found in tinnitus patients, for example. Cortical hyperexcitability is presumably the result of chronicity and the concomitant central sensitisation process.
M3 - SCORING: Zeitschriftenaufsatz
VL - 22
SP - 17
EP - 21
JO - SCHMERZ
JF - SCHMERZ
SN - 0932-433X
IS - 1
M1 - 1
ER -
