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Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis

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Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis. / Appel, Heiner; Loddenkemper, Christoph; Grozdanovic, Zarko; Ebhardt, Harald; Dreimann, Marc; Hempfing, Axel; Stein, Harald; Metz-Stavenhagen, Peter; Rudwaleit, Martin; Sieper, Joachim.

in: ARTHRITIS RES THER, Jahrgang 8, Nr. 5, 01.01.2006, S. R143.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Appel, H, Loddenkemper, C, Grozdanovic, Z, Ebhardt, H, Dreimann, M, Hempfing, A, Stein, H, Metz-Stavenhagen, P, Rudwaleit, M & Sieper, J 2006, 'Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis', ARTHRITIS RES THER, Jg. 8, Nr. 5, S. R143. https://doi.org/10.1186/ar2035

APA

Appel, H., Loddenkemper, C., Grozdanovic, Z., Ebhardt, H., Dreimann, M., Hempfing, A., Stein, H., Metz-Stavenhagen, P., Rudwaleit, M., & Sieper, J. (2006). Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis. ARTHRITIS RES THER, 8(5), R143. https://doi.org/10.1186/ar2035

Vancouver

Appel H, Loddenkemper C, Grozdanovic Z, Ebhardt H, Dreimann M, Hempfing A et al. Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis. ARTHRITIS RES THER. 2006 Jan 1;8(5):R143. https://doi.org/10.1186/ar2035

Bibtex

@article{9095bbdefef343ad94c1909a2db345d5,
title = "Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis",
abstract = "Ankylosing spondylitis (AS) is a chronic inflammatory disease which affects primarily the sacroiliac joints and the spine. In patients with active disease, magnetic resonance imaging (MRI) of the spine shows areas of bone marrow edema, the histopathological equivalent of which is unknown. In this study we correlate inflammation in the spine of patients with AS as revealed by histological examination with bone marrow edema as detected by MRI. We have compared the histopathological findings of zygapophyseal joints from 8 patients with AS (age: 30 to 64, disease duration 7 to 33 years) undergoing spinal surgery with findings in MRI. For histopathological analysis, we quantified infiltrates of CD3+, CD4+ and CD8+ T cells as well as CD20+ B cells immunohistochemically. Bone marrow edema was evaluated in hematoxylin and eosin stained sections and quantified as the percentage of the bone marrow area involved. All patients with AS showed interstitial mononuclear cell infiltrates and various degrees of bone marrow edema (range from 10% to 60%) in histopathological analysis. However, in only three of eight patients histopathological inflammation and edema in the zygapophyseal joints correlated with bone marrow edema in zygapophyseal joints of the lumbar spine as detected by MRI. Interestingly, two of these patients showed the highest histological score for bone marrow edema (60%). This first study correlating histopathological changes in the spine of patients with AS with findings in MRI scans suggests that a substantial degree of bone marrow inflammation and edema is necessary to be detected by MRI.",
keywords = "Adult, Antigens, CD20, Antigens, CD3, B-Lymphocytes, Bone Marrow, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Edema, Female, Humans, Immunohistochemistry, Magnetic Resonance Imaging, Male, Microcirculation, Middle Aged, Spondylitis, Ankylosing, Zygapophyseal Joint",
author = "Heiner Appel and Christoph Loddenkemper and Zarko Grozdanovic and Harald Ebhardt and Marc Dreimann and Axel Hempfing and Harald Stein and Peter Metz-Stavenhagen and Martin Rudwaleit and Joachim Sieper",
year = "2006",
month = jan,
day = "1",
doi = "10.1186/ar2035",
language = "English",
volume = "8",
pages = "R143",
journal = "ARTHRITIS RES THER",
issn = "1478-6354",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis

AU - Appel, Heiner

AU - Loddenkemper, Christoph

AU - Grozdanovic, Zarko

AU - Ebhardt, Harald

AU - Dreimann, Marc

AU - Hempfing, Axel

AU - Stein, Harald

AU - Metz-Stavenhagen, Peter

AU - Rudwaleit, Martin

AU - Sieper, Joachim

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Ankylosing spondylitis (AS) is a chronic inflammatory disease which affects primarily the sacroiliac joints and the spine. In patients with active disease, magnetic resonance imaging (MRI) of the spine shows areas of bone marrow edema, the histopathological equivalent of which is unknown. In this study we correlate inflammation in the spine of patients with AS as revealed by histological examination with bone marrow edema as detected by MRI. We have compared the histopathological findings of zygapophyseal joints from 8 patients with AS (age: 30 to 64, disease duration 7 to 33 years) undergoing spinal surgery with findings in MRI. For histopathological analysis, we quantified infiltrates of CD3+, CD4+ and CD8+ T cells as well as CD20+ B cells immunohistochemically. Bone marrow edema was evaluated in hematoxylin and eosin stained sections and quantified as the percentage of the bone marrow area involved. All patients with AS showed interstitial mononuclear cell infiltrates and various degrees of bone marrow edema (range from 10% to 60%) in histopathological analysis. However, in only three of eight patients histopathological inflammation and edema in the zygapophyseal joints correlated with bone marrow edema in zygapophyseal joints of the lumbar spine as detected by MRI. Interestingly, two of these patients showed the highest histological score for bone marrow edema (60%). This first study correlating histopathological changes in the spine of patients with AS with findings in MRI scans suggests that a substantial degree of bone marrow inflammation and edema is necessary to be detected by MRI.

AB - Ankylosing spondylitis (AS) is a chronic inflammatory disease which affects primarily the sacroiliac joints and the spine. In patients with active disease, magnetic resonance imaging (MRI) of the spine shows areas of bone marrow edema, the histopathological equivalent of which is unknown. In this study we correlate inflammation in the spine of patients with AS as revealed by histological examination with bone marrow edema as detected by MRI. We have compared the histopathological findings of zygapophyseal joints from 8 patients with AS (age: 30 to 64, disease duration 7 to 33 years) undergoing spinal surgery with findings in MRI. For histopathological analysis, we quantified infiltrates of CD3+, CD4+ and CD8+ T cells as well as CD20+ B cells immunohistochemically. Bone marrow edema was evaluated in hematoxylin and eosin stained sections and quantified as the percentage of the bone marrow area involved. All patients with AS showed interstitial mononuclear cell infiltrates and various degrees of bone marrow edema (range from 10% to 60%) in histopathological analysis. However, in only three of eight patients histopathological inflammation and edema in the zygapophyseal joints correlated with bone marrow edema in zygapophyseal joints of the lumbar spine as detected by MRI. Interestingly, two of these patients showed the highest histological score for bone marrow edema (60%). This first study correlating histopathological changes in the spine of patients with AS with findings in MRI scans suggests that a substantial degree of bone marrow inflammation and edema is necessary to be detected by MRI.

KW - Adult

KW - Antigens, CD20

KW - Antigens, CD3

KW - B-Lymphocytes

KW - Bone Marrow

KW - CD4-Positive T-Lymphocytes

KW - CD8-Positive T-Lymphocytes

KW - Edema

KW - Female

KW - Humans

KW - Immunohistochemistry

KW - Magnetic Resonance Imaging

KW - Male

KW - Microcirculation

KW - Middle Aged

KW - Spondylitis, Ankylosing

KW - Zygapophyseal Joint

U2 - 10.1186/ar2035

DO - 10.1186/ar2035

M3 - SCORING: Journal article

C2 - 16925803

VL - 8

SP - R143

JO - ARTHRITIS RES THER

JF - ARTHRITIS RES THER

SN - 1478-6354

IS - 5

ER -