Correlation between DNA damage responses of skin to a test dose of radiation and late adverse effects of earlier breast radiotherapy
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Correlation between DNA damage responses of skin to a test dose of radiation and late adverse effects of earlier breast radiotherapy. / Somaiah, Navita; Chua, Melvin L K; Bourne, Sara; Daley, Frances; A' Hern, Roger; Nuta, Otilia; Gothard, Lone; Boyle, Sue; Herskind, Carsten; Pearson, Ann; Warrington, Jim; Helyer, Sarah; Owen, Roger; Rothkamm, Kai; Yarnold, John.
in: RADIOTHER ONCOL, Jahrgang 119, Nr. 2, 05.2016, S. 244-9.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Correlation between DNA damage responses of skin to a test dose of radiation and late adverse effects of earlier breast radiotherapy
AU - Somaiah, Navita
AU - Chua, Melvin L K
AU - Bourne, Sara
AU - Daley, Frances
AU - A' Hern, Roger
AU - Nuta, Otilia
AU - Gothard, Lone
AU - Boyle, Sue
AU - Herskind, Carsten
AU - Pearson, Ann
AU - Warrington, Jim
AU - Helyer, Sarah
AU - Owen, Roger
AU - Rothkamm, Kai
AU - Yarnold, John
N1 - Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.
PY - 2016/5
Y1 - 2016/5
N2 - AIM: To correlate residual double strand breaks (DSB) 24h after 4Gy test doses to skin in vivo and to lymphocytes in vitro with adverse effects of earlier breast radiotherapy (RT).PATIENTS AND METHODS: Patients given whole breast RT ⩾5years earlier were identified on the basis of moderate/marked or minimal/no adverse effects despite the absence ('RT-Sensitive', RT-S) or presence ('RT-Resistant', RT-R) of variables predisposing to late adverse effects. Residual DSB were quantified in skin 24h after a 4Gy test dose in 20 RT-S and 15 RT-R patients. Residual DSB were quantified in lymphocytes irradiated with 4Gy in vitro in 30/35 patients.RESULTS: Mean foci per dermal fibroblast were 3.29 (RT-S) vs 2.80 (RT-R) (p=0.137); 3.28 (RT-S) vs 2.60 (RT-R) in endothelium (p=0.158); 2.50 (RT-S) vs 2.41 (RT-R) in suprabasal keratinocytes (p=0.633); 2.70 (RT-S) vs 2.35 (RT-R) in basal epidermis (p=0.419); 12.1 (RT-S) vs 10.3 (RT-R) in lymphocytes (p=0.0052).CONCLUSIONS: Residual DSB in skin following a 4Gy dose were not significantly associated with risk of late adverse effects of breast radiotherapy, although exploratory analyses suggested an association in severely affected individuals. By contrast, a significant association was detected based on the in vitro response of lymphocytes.
AB - AIM: To correlate residual double strand breaks (DSB) 24h after 4Gy test doses to skin in vivo and to lymphocytes in vitro with adverse effects of earlier breast radiotherapy (RT).PATIENTS AND METHODS: Patients given whole breast RT ⩾5years earlier were identified on the basis of moderate/marked or minimal/no adverse effects despite the absence ('RT-Sensitive', RT-S) or presence ('RT-Resistant', RT-R) of variables predisposing to late adverse effects. Residual DSB were quantified in skin 24h after a 4Gy test dose in 20 RT-S and 15 RT-R patients. Residual DSB were quantified in lymphocytes irradiated with 4Gy in vitro in 30/35 patients.RESULTS: Mean foci per dermal fibroblast were 3.29 (RT-S) vs 2.80 (RT-R) (p=0.137); 3.28 (RT-S) vs 2.60 (RT-R) in endothelium (p=0.158); 2.50 (RT-S) vs 2.41 (RT-R) in suprabasal keratinocytes (p=0.633); 2.70 (RT-S) vs 2.35 (RT-R) in basal epidermis (p=0.419); 12.1 (RT-S) vs 10.3 (RT-R) in lymphocytes (p=0.0052).CONCLUSIONS: Residual DSB in skin following a 4Gy dose were not significantly associated with risk of late adverse effects of breast radiotherapy, although exploratory analyses suggested an association in severely affected individuals. By contrast, a significant association was detected based on the in vitro response of lymphocytes.
U2 - 10.1016/j.radonc.2016.04.012
DO - 10.1016/j.radonc.2016.04.012
M3 - SCORING: Journal article
C2 - 27106550
VL - 119
SP - 244
EP - 249
JO - RADIOTHER ONCOL
JF - RADIOTHER ONCOL
SN - 0167-8140
IS - 2
ER -