Cord blood leptin and IGF-I in relation to birth weight differences and head circumference in monozygotic twins.
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Cord blood leptin and IGF-I in relation to birth weight differences and head circumference in monozygotic twins. / Gohlke, Bettina C; Huber, Agnes; Bartmann, Peter; Fimmers, Rolf; Hecher, Kurt; Bouret, Sebastien G; Roth, Christian L.
in: J PEDIATR ENDOCR MET, Jahrgang 19, Nr. 1, 1, 2006, S. 3-9.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cord blood leptin and IGF-I in relation to birth weight differences and head circumference in monozygotic twins.
AU - Gohlke, Bettina C
AU - Huber, Agnes
AU - Bartmann, Peter
AU - Fimmers, Rolf
AU - Hecher, Kurt
AU - Bouret, Sebastien G
AU - Roth, Christian L
PY - 2006
Y1 - 2006
N2 - OBJECTIVES: To investigate a potential role of leptin and insulin-like growth factor (IGF)-I on fetal growth and metabolic function we determined plasma leptin and IGF-I concentrations in twins in relation to discordant fetal growth. STUDY DESIGN: In studying monochorionic twins with inter-twin birth weight difference, we investigated the relative contribution of genetic (fetus) versus environmental (maternal/placental) factors on growth. Thirty-six sets of twins (14 with discordant growth, birth weight difference >15%) who had been treated for severe twin-to-twin transfusion syndrome (TTTS) by laser coagulation were studied. Cord blood samples were collected at birth and analyzed for IGF-I and leptin. Inter-twin differences (delta) of birth weight and head circumference were correlated to delta hormone levels. RESULTS: An inter-twin correlation for leptin (r = 0.69; p
AB - OBJECTIVES: To investigate a potential role of leptin and insulin-like growth factor (IGF)-I on fetal growth and metabolic function we determined plasma leptin and IGF-I concentrations in twins in relation to discordant fetal growth. STUDY DESIGN: In studying monochorionic twins with inter-twin birth weight difference, we investigated the relative contribution of genetic (fetus) versus environmental (maternal/placental) factors on growth. Thirty-six sets of twins (14 with discordant growth, birth weight difference >15%) who had been treated for severe twin-to-twin transfusion syndrome (TTTS) by laser coagulation were studied. Cord blood samples were collected at birth and analyzed for IGF-I and leptin. Inter-twin differences (delta) of birth weight and head circumference were correlated to delta hormone levels. RESULTS: An inter-twin correlation for leptin (r = 0.69; p
M3 - SCORING: Zeitschriftenaufsatz
VL - 19
SP - 3
EP - 9
JO - J PEDIATR ENDOCR MET
JF - J PEDIATR ENDOCR MET
SN - 0334-018X
IS - 1
M1 - 1
ER -