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Copy Number Variation Analysis on Cell-Free Serum DNA

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Copy Number Variation Analysis on Cell-Free Serum DNA. / Schwarzenbach, Heidi.

Cell-free DNA as Diagnostic Markers: Methods and Protocols. Hrsg. / Valentina Casadio; Samanta Salvi. Band 1909 1. Aufl. New York : Humana Press, 2019. S. 85-93 (Methods Mol Biol).

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Harvard

Schwarzenbach, H 2019, Copy Number Variation Analysis on Cell-Free Serum DNA. in V Casadio & S Salvi (Hrsg.), Cell-free DNA as Diagnostic Markers: Methods and Protocols. 1 Aufl., Bd. 1909, Methods Mol Biol, Humana Press, New York, S. 85-93. https://doi.org/10.1007/978-1-4939-8973-7_6

APA

Schwarzenbach, H. (2019). Copy Number Variation Analysis on Cell-Free Serum DNA. in V. Casadio, & S. Salvi (Hrsg.), Cell-free DNA as Diagnostic Markers: Methods and Protocols (1 Aufl., Band 1909, S. 85-93). (Methods Mol Biol). Humana Press. https://doi.org/10.1007/978-1-4939-8973-7_6

Vancouver

Schwarzenbach H. Copy Number Variation Analysis on Cell-Free Serum DNA. in Casadio V, Salvi S, Hrsg., Cell-free DNA as Diagnostic Markers: Methods and Protocols. 1 Aufl. Band 1909. New York: Humana Press. 2019. S. 85-93. (Methods Mol Biol). https://doi.org/10.1007/978-1-4939-8973-7_6

Bibtex

@inbook{77d80470ce234ded8f8404594b451659,
title = "Copy Number Variation Analysis on Cell-Free Serum DNA",
abstract = "Genome diversity comprises single nucleotide polymorphisms, deletions, insertions, and duplications. These gains and losses of DNA segments leading to rearrangements of sequences are termed copy number variations (CNVs). CNVs may disrupt genes and/or alter gene dosage and, thereby, have an impact on both protein-coding and noncoding genes. Accordingly, they affect the activity of various signaling pathways and influence the cell phenotype. They are associated with risks for several severe diseases, in particular cancer. In the current chapter, I introduce a rapid profiling method to identify CNVs in circulating, cell-free DNA by multiplex ligation-dependent probe amplification (MLPA). MLPA represents an efficient method for the detection of CNVs among numerous genes on various chromosomal regions in serum.",
keywords = "Journal Article",
author = "Heidi Schwarzenbach",
year = "2019",
doi = "10.1007/978-1-4939-8973-7_6",
language = "English",
isbn = "978-1493989720",
volume = "1909",
series = "Methods Mol Biol",
publisher = "Humana Press",
pages = "85--93",
editor = "Valentina Casadio and Samanta Salvi",
booktitle = "Cell-free DNA as Diagnostic Markers",
address = "United States",
edition = "1",

}

RIS

TY - CHAP

T1 - Copy Number Variation Analysis on Cell-Free Serum DNA

AU - Schwarzenbach, Heidi

PY - 2019

Y1 - 2019

N2 - Genome diversity comprises single nucleotide polymorphisms, deletions, insertions, and duplications. These gains and losses of DNA segments leading to rearrangements of sequences are termed copy number variations (CNVs). CNVs may disrupt genes and/or alter gene dosage and, thereby, have an impact on both protein-coding and noncoding genes. Accordingly, they affect the activity of various signaling pathways and influence the cell phenotype. They are associated with risks for several severe diseases, in particular cancer. In the current chapter, I introduce a rapid profiling method to identify CNVs in circulating, cell-free DNA by multiplex ligation-dependent probe amplification (MLPA). MLPA represents an efficient method for the detection of CNVs among numerous genes on various chromosomal regions in serum.

AB - Genome diversity comprises single nucleotide polymorphisms, deletions, insertions, and duplications. These gains and losses of DNA segments leading to rearrangements of sequences are termed copy number variations (CNVs). CNVs may disrupt genes and/or alter gene dosage and, thereby, have an impact on both protein-coding and noncoding genes. Accordingly, they affect the activity of various signaling pathways and influence the cell phenotype. They are associated with risks for several severe diseases, in particular cancer. In the current chapter, I introduce a rapid profiling method to identify CNVs in circulating, cell-free DNA by multiplex ligation-dependent probe amplification (MLPA). MLPA represents an efficient method for the detection of CNVs among numerous genes on various chromosomal regions in serum.

KW - Journal Article

U2 - 10.1007/978-1-4939-8973-7_6

DO - 10.1007/978-1-4939-8973-7_6

M3 - SCORING: Contribution to collected editions/anthologies

C2 - 30580424

SN - 978-1493989720

VL - 1909

T3 - Methods Mol Biol

SP - 85

EP - 93

BT - Cell-free DNA as Diagnostic Markers

A2 - Casadio, Valentina

A2 - Salvi, Samanta

PB - Humana Press

CY - New York

ER -