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Cooling Activity is Associated with Neurological Outcome in Patients with Severe Cerebrovascular Disease Undergoing Endovascular Temperature Control

Standard

Cooling Activity is Associated with Neurological Outcome in Patients with Severe Cerebrovascular Disease Undergoing Endovascular Temperature Control. / Fischer, Marlene; Lackner, Peter; Beer, Ronny; Helbok, Raimund; Pfausler, Bettina; Schneider, Dietmar; Schmutzhard, Erich; Broessner, Gregor.

in: NEUROCRIT CARE, Jahrgang 23, Nr. 2, 10.2015, S. 205-9.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fischer, M, Lackner, P, Beer, R, Helbok, R, Pfausler, B, Schneider, D, Schmutzhard, E & Broessner, G 2015, 'Cooling Activity is Associated with Neurological Outcome in Patients with Severe Cerebrovascular Disease Undergoing Endovascular Temperature Control', NEUROCRIT CARE, Jg. 23, Nr. 2, S. 205-9. https://doi.org/10.1007/s12028-015-0122-0

APA

Fischer, M., Lackner, P., Beer, R., Helbok, R., Pfausler, B., Schneider, D., Schmutzhard, E., & Broessner, G. (2015). Cooling Activity is Associated with Neurological Outcome in Patients with Severe Cerebrovascular Disease Undergoing Endovascular Temperature Control. NEUROCRIT CARE, 23(2), 205-9. https://doi.org/10.1007/s12028-015-0122-0

Vancouver

Fischer M, Lackner P, Beer R, Helbok R, Pfausler B, Schneider D et al. Cooling Activity is Associated with Neurological Outcome in Patients with Severe Cerebrovascular Disease Undergoing Endovascular Temperature Control. NEUROCRIT CARE. 2015 Okt;23(2):205-9. https://doi.org/10.1007/s12028-015-0122-0

Bibtex

@article{951f1b29237a46bf838301cdfe8c26e8,
title = "Cooling Activity is Associated with Neurological Outcome in Patients with Severe Cerebrovascular Disease Undergoing Endovascular Temperature Control",
abstract = "BACKGROUND: Neuroprotection through targeted temperature management is currently investigated in patients with severe brain injury in multiple trials. Feedback devices have been shown to precisely reach and maintain target temperature by constantly adjusting cooling activity. We analyzed the association between cooling activity expressed as cool bath temperatures and functional neurological outcome.METHODS: Data were retrospectively analyzed from a prospective randomized trial on controlled prophylactic normothermia (i.e., 36.5 °C) in patients with severe cerebrovascular disease. Body core temperature of patients who had been randomized to the endovascular group, was controlled using an endovascular cooling device. Cool bath temperature was analyzed over a period of 168 h. Functional neurological outcome was evaluated at 180 days using the modified Rankin Scale.RESULTS: 51 of 102 patients included were randomized to the endovascular group. Cool bath temperature data were available from 47/51 patients. Patients with lower cool bath temperatures reflecting high cooling activity had a more favorable neurological outcome at 180 days (mRS 0-2) than patients with low cooling activity (p < 0.05). We did not find a significant correlation between cool bath temperature and inflammatory markers.CONCLUSION: High cooling activity of an endovascular feedback device is associated with favorable outcome in patients with severe cerebrovascular disease.",
author = "Marlene Fischer and Peter Lackner and Ronny Beer and Raimund Helbok and Bettina Pfausler and Dietmar Schneider and Erich Schmutzhard and Gregor Broessner",
year = "2015",
month = oct,
doi = "10.1007/s12028-015-0122-0",
language = "English",
volume = "23",
pages = "205--9",
journal = "NEUROCRIT CARE",
issn = "1541-6933",
publisher = "Humana Press",
number = "2",

}

RIS

TY - JOUR

T1 - Cooling Activity is Associated with Neurological Outcome in Patients with Severe Cerebrovascular Disease Undergoing Endovascular Temperature Control

AU - Fischer, Marlene

AU - Lackner, Peter

AU - Beer, Ronny

AU - Helbok, Raimund

AU - Pfausler, Bettina

AU - Schneider, Dietmar

AU - Schmutzhard, Erich

AU - Broessner, Gregor

PY - 2015/10

Y1 - 2015/10

N2 - BACKGROUND: Neuroprotection through targeted temperature management is currently investigated in patients with severe brain injury in multiple trials. Feedback devices have been shown to precisely reach and maintain target temperature by constantly adjusting cooling activity. We analyzed the association between cooling activity expressed as cool bath temperatures and functional neurological outcome.METHODS: Data were retrospectively analyzed from a prospective randomized trial on controlled prophylactic normothermia (i.e., 36.5 °C) in patients with severe cerebrovascular disease. Body core temperature of patients who had been randomized to the endovascular group, was controlled using an endovascular cooling device. Cool bath temperature was analyzed over a period of 168 h. Functional neurological outcome was evaluated at 180 days using the modified Rankin Scale.RESULTS: 51 of 102 patients included were randomized to the endovascular group. Cool bath temperature data were available from 47/51 patients. Patients with lower cool bath temperatures reflecting high cooling activity had a more favorable neurological outcome at 180 days (mRS 0-2) than patients with low cooling activity (p < 0.05). We did not find a significant correlation between cool bath temperature and inflammatory markers.CONCLUSION: High cooling activity of an endovascular feedback device is associated with favorable outcome in patients with severe cerebrovascular disease.

AB - BACKGROUND: Neuroprotection through targeted temperature management is currently investigated in patients with severe brain injury in multiple trials. Feedback devices have been shown to precisely reach and maintain target temperature by constantly adjusting cooling activity. We analyzed the association between cooling activity expressed as cool bath temperatures and functional neurological outcome.METHODS: Data were retrospectively analyzed from a prospective randomized trial on controlled prophylactic normothermia (i.e., 36.5 °C) in patients with severe cerebrovascular disease. Body core temperature of patients who had been randomized to the endovascular group, was controlled using an endovascular cooling device. Cool bath temperature was analyzed over a period of 168 h. Functional neurological outcome was evaluated at 180 days using the modified Rankin Scale.RESULTS: 51 of 102 patients included were randomized to the endovascular group. Cool bath temperature data were available from 47/51 patients. Patients with lower cool bath temperatures reflecting high cooling activity had a more favorable neurological outcome at 180 days (mRS 0-2) than patients with low cooling activity (p < 0.05). We did not find a significant correlation between cool bath temperature and inflammatory markers.CONCLUSION: High cooling activity of an endovascular feedback device is associated with favorable outcome in patients with severe cerebrovascular disease.

U2 - 10.1007/s12028-015-0122-0

DO - 10.1007/s12028-015-0122-0

M3 - SCORING: Journal article

C2 - 25693893

VL - 23

SP - 205

EP - 209

JO - NEUROCRIT CARE

JF - NEUROCRIT CARE

SN - 1541-6933

IS - 2

ER -